{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:34:48Z","timestamp":1768005288706,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T00:00:00Z","timestamp":1328227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00259-011-2050-3","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T15:38:59Z","timestamp":1328197139000},"page":"824-839","source":"Crossref","is-referenced-by-count":13,"title":["Imaging small human prostate cancer xenografts after pretargeting with bispecific bombesin-antibody complexes and targeting with high specific radioactivity labeled polymer-drug conjugates"],"prefix":"10.1007","volume":"39","author":[{"given":"Vishwesh","family":"Patil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur","family":"Gada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Panwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Varvarigou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Weisenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yared","family":"Tekabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ban-An","family":"Khaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,3]]},"reference":[{"key":"2050_CR1","first-page":"422","volume-title":"Collected studies on immunity","author":"P Ehrlich","year":"1906","unstructured":"Ehrlich P. Collected studies on immunity, vol. 2. New York: Wiley; 1906. p. 422."},{"key":"2050_CR2","first-page":"73","volume":"5","author":"RO Dillman","year":"1986","unstructured":"Dillman RO, Dillman JB, Beauregard JC, Halpern SE, Clutter M. Toxicities and side effects associated with intravenous infusions of murine monoclonal antibodies. J Biol Response Mod 1986;5:73\u201384.","journal-title":"J Biol Response Mod"},{"key":"2050_CR3","first-page":"1","volume":"3","author":"RO Dillman","year":"1990","unstructured":"Dillman RO. Human antimouse and antiglobulin responses to monoclonal antibodies. Antibody Immunoconj Radiopharm 1990;3:1\u201315.","journal-title":"Antibody Immunoconj Radiopharm"},{"key":"2050_CR4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1071-3581(05)80005-4","volume":"2","author":"J Narula","year":"1995","unstructured":"Narula J, Torchilin VP, Petrov A, Khaw S, Trubetskoy VS, O\u2019Donnell SM, et al. In vivo targeting of acute myocardial infarction with negative-charge, polymer-modified antimyosin antibody: use of different cross-linkers. J Nucl Cardiol 1995;2:26\u201334.","journal-title":"J Nucl Cardiol"},{"key":"2050_CR5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0169-409X(01)00206-X","volume":"53","author":"PD Senter","year":"2001","unstructured":"Senter PD, Springer CJ. Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates. Adv Drug Deliv Rev 2001;53:247\u201364.","journal-title":"Adv Drug Deliv Rev"},{"issue":"10","key":"2050_CR6","first-page":"1678","volume":"47","author":"WJ McBride","year":"2006","unstructured":"McBride WJ, Zanzonico P, Sharkey RM, Nor\u00e9n C, Karacay H, Rossi EA, Losman MJ, Brard P-Y, Chang CH, Larson SM, Goldenberg DM. Bispecific antibody pretargeting PET (immunoPET) with an 124I-labeled hapten-peptide. J Nucl Med 2006;47(10):1678\u201388.","journal-title":"J Nucl Med"},{"key":"2050_CR7","first-page":"868","volume":"47","author":"BA Khaw","year":"2006","unstructured":"Khaw BA, Tekabe Y, Johnson LL. Imaging experimental atherosclerotic lesions in ApoE knockout mice: enhanced targeting with Z2D3-anti-DTPA bispecific antibody and 99mTc-labeled negatively charged polymers. J Nucl Med 2006;47:868\u201376.","journal-title":"J Nucl Med"},{"key":"2050_CR8","first-page":"427","volume":"4","author":"DA Goodwin","year":"1991","unstructured":"Goodwin DA. Strategies for antibody targeting. Antibody Immunoconj Radiopharm 1991;4:427\u201334.","journal-title":"Antibody Immunoconj Radiopharm"},{"key":"2050_CR9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00262-007-0357-5","volume":"57","author":"MG Fury","year":"2008","unstructured":"Fury MG, Lipton A, Smith KM, Winston CB, Pfister DG. A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors. Cancer Immunol Immunother 2008;57:155\u201363.","journal-title":"Cancer Immunol Immunother"},{"issue":"4","key":"2050_CR10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/MNM.0b013e32833576e8","volume":"31","author":"Y Tekabe","year":"2010","unstructured":"Tekabe Y, Einstein AJ, Johnson LL, Khaw BA. Targeting very small model lesions pretargeted with bispecific antibody with 99mTc-labeled high-specific radioactivity polymers: imaging low abundance targets in model lesions. Nucl Med Commun 2010;31(4):320\u20137.","journal-title":"Nucl Med Commun"},{"key":"2050_CR11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jlb.41.2.143","volume":"41","author":"FC Silva Filho","year":"1987","unstructured":"Silva Filho FC, Santos ABS, de Carvalho TMU, de Souza W. Surface charge of resident, elicited, and activated mouse peritoneal macrophages. J Leukoc Biol 1987;41:143\u20139.","journal-title":"J Leukoc Biol"},{"key":"2050_CR12","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1164\/arrd.1987.135.6.1345","volume":"135","author":"JE Gallagher","year":"1987","unstructured":"Gallagher JE, George G, Brody AR. Sialic acid mediates the initial binding of positively charged inorganic particles to alveolar macrophage membranes. Am Rev Respir Dis 1987;135:1345\u201352.","journal-title":"Am Rev Respir Dis"},{"key":"2050_CR13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1357-2725(99)00116-8","volume":"32","author":"S Tumova","year":"2000","unstructured":"Tumova S, Woods A, Couchman JR. Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions. Int J Biochem Cell Biol 2000;32:269\u201388.","journal-title":"Int J Biochem Cell Biol"},{"key":"2050_CR14","first-page":"1742","volume":"32","author":"BA Khaw","year":"1991","unstructured":"Khaw BA, Klibanov A, O\u2019Donnell SM, Saito T, Nossiff N, Slinkin MA, Newell JB, Strauss HW, Torchilin VP. Gamma imaging with negatively charge-modified monoclonal antibody: modification with synthetic polymers. J Nucl Med 1991;32:1742\u201351.","journal-title":"J Nucl Med"},{"key":"2050_CR15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1071-3581(98)90108-8","volume":"5","author":"I Carri\u00f3","year":"1998","unstructured":"Carri\u00f3 I, Pieri PL, Narula J, Prat L, Riva P, Pedrini L, Pretolani E, Caruso G, Sarti G, Estorch M, Bern\u00e1 L, Riambau V, Mat\u00edas-Guiu X, Pak C, Ditlow C, Chen F, Khaw BA. Noninvasive localization of human atherosclerotic lesions with In-111-labeled monoclonal Z2D3 antibody specific for proliferating smooth muscle cells. J Nucl Cardiol 1998;5:551\u20137.","journal-title":"J Nucl Cardiol"},{"key":"2050_CR16","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/MNM.0b013e32834af77b","volume":"32","author":"KS Gada","year":"2011","unstructured":"Gada KS, Patil V, Panwar R, Majewski S, Tekabe Y, Khaw BA. Pretargeted gamma imaging of murine metastatic melanoma lung lesions with bispecific antibody and radiolabeled polymer drug conjugates. Nucl Med Commun 2011;32:1231\u201340.","journal-title":"Nucl Med Commun"},{"key":"2050_CR17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/108497804323072002","volume":"19","author":"A Varvarigou","year":"2004","unstructured":"Varvarigou A, Bouziotis P, Zikos C, Scopinaro F, De Vincentis G. Gastrin-releasing peptide (GRP) analogues for cancer imaging. Cancer Biother Radiopharm 2004;19:219\u201329.","journal-title":"Cancer Biother Radiopharm"},{"key":"2050_CR18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/adt.2005.3.319","volume":"3","author":"BA Khaw","year":"2005","unstructured":"Khaw BA, Rammohan R, Abu-Taka A. Bispecific enzyme-linked signal-enhanced immunoassay with subattomole sensitivity. Assay Drug Dev Technol 2005;3:319\u201327.","journal-title":"Assay Drug Dev Technol"},{"key":"2050_CR19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0003-2697(86)90231-9","volume":"155","author":"M Bernatowicz","year":"1986","unstructured":"Bernatowicz M, Matsueda GR. Preparation of peptide-protein immunogens using N-succinimidyl bromoacetate as a heterobifunctional crosslinking reagent. Anal Biochem 1986;155:95\u2013102.","journal-title":"Anal Biochem"},{"key":"2050_CR20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0003-2697(66)90275-2","volume":"14","author":"AFSA Habeeb","year":"1966","unstructured":"Habeeb AFSA. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal Biochem 1966;14:328\u201336.","journal-title":"Anal Biochem"},{"key":"2050_CR21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0076-6879(86)21065-4","volume":"121","author":"J Rousseaux","year":"1986","unstructured":"Rousseaux J, Rousseaux-Prevost R, Bazin H. Optimal conditions for the preparation of proteolytic fragments from monoclonal IgG of different rat IgG subclasses. Methods Enzymol 1986;121:663\u20139.","journal-title":"Methods Enzymol"},{"key":"2050_CR22","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/bc050201y","volume":"16","author":"MM Sun","year":"2005","unstructured":"Sun MM, Beam KS, Cerveny CG, Hamblett KJ, Blackmore RS, Torgov MY, et al. Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides. Bioconjug Chem 2005;16:1282\u201390.","journal-title":"Bioconjug Chem"},{"key":"2050_CR23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1071-3581(97)90083-0","volume":"4","author":"J Narula","year":"1997","unstructured":"Narula J, Petrov A, Ditlow C, Pak KY, Chen FW, Khaw BA. Maximizing radiotracer delivery to experimental atherosclerotic lesions with high-dose, negative charge-modified Z2D3 antibody for immunoscintigraphic targeting. J Nucl Cardiol 1997;4:226\u201333.","journal-title":"J Nucl Cardiol"},{"key":"2050_CR24","unstructured":"Hammond W, Tekabe Y, Johnson L, Majewski S, Popov V, Kross B, et al. Development of high performance mini gamma cameras based on LaBr3 scintillator and H8500 and H9500 PSPMTs and their use in small animal studies. IEEE Medical Imaging Conference. San Diego: 2006. Oct 29\u2013Nov 4"},{"key":"2050_CR25","first-page":"262","volume":"3","author":"T Ghose","year":"1987","unstructured":"Ghose T, Blair AH. The design of cytotoxic agent-antibody conjugates. Crit Rev Ther Drug Carrier Syst 1987;3:262.","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"issue":"9","key":"2050_CR26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0167-5699(89)90082-0","volume":"10","author":"DM Goldenberg","year":"1989","unstructured":"Goldenberg DM. Targeted cancer treatment. Immunol Today 1989;10(9):286\u20138.","journal-title":"Immunol Today"},{"issue":"5","key":"2050_CR27","first-page":"1175","volume":"35","author":"E Hurwitz","year":"1975","unstructured":"Hurwitz E, Levy R, Maron R, Wilchek M, Arnon R, Sela M. The covalent binding of daunomycin and adriamycin to antibodies, with retention of both drug and antibody activities. Cancer Res 1975;35(5):1175\u201381.","journal-title":"Cancer Res"},{"issue":"6","key":"2050_CR28","first-page":"2073","volume":"41","author":"V Raso","year":"1981","unstructured":"Raso V, Griffin T. Hybrid antibodies with dual specificity for the delivery of ricin to immunoglobulin-bearing target cells. Cancer Res 1981;41(6):2073\u20138.","journal-title":"Cancer Res"},{"issue":"6","key":"2050_CR29","first-page":"580","volume":"112","author":"DM Goldenberg","year":"1988","unstructured":"Goldenberg DM. Targeting of cancer with radiolabeled antibodies. Prospects for imaging and therapy. Arch Pathol Lab Med 1988;112(6):580\u20137.","journal-title":"Arch Pathol Lab Med"},{"key":"2050_CR30","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1021\/bc0000379","volume":"11","author":"H Karacay","year":"2000","unstructured":"Karacay H, McBride WJ, Griffiths GL, Sharkey RM, Barbet J, Hansen HJ, et al. Experimental pretargeting studies of cancer with a humanized anti-CEA x murine anti-[In-DTPA] bispecific antibody construct and a (99m)Tc-\/(188)Re-labeled peptide. Bioconjug Chem 2000;11:842\u201354.","journal-title":"Bioconjug Chem"},{"key":"2050_CR31","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/bjc.1990.115","volume":"61","author":"MV Pimm","year":"1990","unstructured":"Pimm MV, Robins RA, Embleton MJ, Markham AJ, Charleston A, Baldwin RW. A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate- carrier conjugate. Br J Cancer 1990;61:508\u201313.","journal-title":"Br J Cancer"},{"key":"2050_CR32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.uct.2007.04.003","volume":"2","author":"D Goldenberg","year":"2007","unstructured":"Goldenberg D, Chatal JF, Barbet J, Boerman O, Sharkey R. Cancer imaging and therapy with bispecific antibody pretargeting. Update Cancer Ther 2007;2:19\u201331.","journal-title":"Update Cancer Ther"},{"key":"2050_CR33","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.2042-7158.1970.tb08465.x","volume":"22","author":"V Erspamer","year":"1970","unstructured":"Erspamer V, Erpamer GF, Inselvini M. Some pharmacological actions of alytesin and bombesin. J Pharm Pharmacol 1970;22:875\u20136.","journal-title":"J Pharm Pharmacol"},{"key":"2050_CR34","doi-asserted-by":"crossref","unstructured":"Jensen RT, Moody TW. Bombesin-related peptides and neurotensin: effects on cancer growth\/proliferation and cellular signaling in cancer. In: Kastin AJ, editor. Handbook of biologically active peptides. New York: Academic; 2006. p.\u00a0429\u201334.","DOI":"10.1016\/B978-012369442-3\/50064-7"},{"key":"2050_CR35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1148\/radiol.2431030580","volume":"243","author":"H Hricak","year":"2007","unstructured":"Hricak H, Choyke PL, Eberhardt SC, Leibel SA, Scardino PT. Imaging prostate cancer: a multidisciplinary perspective. Radiology 2007;243:28\u201353.","journal-title":"Radiology"},{"issue":"1\u20132","key":"2050_CR36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","volume":"65","author":"H Maeda","year":"2000","unstructured":"Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000;65(1\u20132):271\u201384.","journal-title":"J Control Release"},{"key":"2050_CR37","first-page":"138","volume":"20","author":"MW Billinghurst","year":"1979","unstructured":"Billinghurst MW, Rempel S, Westendorf BA. Radiation decomposition of technetium-99m radiopharmaceuticals. J Nucl Med 1979;20:138\u201343.","journal-title":"J Nucl Med"},{"issue":"4","key":"2050_CR38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1021\/mp200014h","volume":"8","author":"HJ Ananias","year":"2011","unstructured":"Ananias HJ, Yu Z, Dierckx RA, van der Wiele C, Helfrich W, Wang F, et al. (99m)Technetium-HYNIC(tricine\/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model. Mol Pharm 2011;8(4):1165\u201373.","journal-title":"Mol Pharm"},{"issue":"2","key":"2050_CR39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0143-4179(97)90086-X","volume":"31","author":"Y Aalto","year":"1997","unstructured":"Aalto Y, Kj\u00f6rell U, Henriksson R, Franz\u00e9n L, Forsgren S. Bombesin-like peptide is present in the duct cells in salivary glands: studies on normal and irradiated animals. Neuropeptides 1997;31(2):167\u201373.","journal-title":"Neuropeptides"},{"key":"2050_CR40","unstructured":"Khaw BA, Patil V, Gada K, Varvarigou V, Majewski S, Tekabe Y, et al. Demonstration of enhanced targeted delivery of drug-loaded polymers with bombesin-bispecific antibody complex for cancer therapy. 36th annual meeting and exposition of the controlled release society. 2009."}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-011-2050-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-011-2050-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-011-2050-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T04:52:04Z","timestamp":1561265524000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-011-2050-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,3]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["2050"],"URL":"https:\/\/doi.org\/10.1007\/s00259-011-2050-3","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,3]]}}}