{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:24:26Z","timestamp":1767677066293},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T00:00:00Z","timestamp":1400284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00259-014-2782-y","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T15:23:49Z","timestamp":1400253829000},"page":"1947-1956","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["11C-ORM-13070, a novel PET ligand for brain \u03b12C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men"],"prefix":"10.1007","volume":"41","author":[{"given":"Pauliina","family":"Luoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Suilamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesa","family":"Oikonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveliina","family":"Arponen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semi","family":"Helin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Herttuainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Hietam\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aila","family":"Holopainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Kailaj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha M.","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Rouru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Sallinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Scheinin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jere","family":"Virta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iina","family":"Volanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Roivainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha O.","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,17]]},"reference":[{"key":"2782_CR1","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/S0024-3205(01)01016-5","volume":"68","author":"M Scheinin","year":"2001","unstructured":"Scheinin M, Sallinen J, Haapalinna A. Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target \u2013 studies in transgenic mouse models. Life Sci. 2001;68:2277\u201385.","journal-title":"Life Sci"},{"key":"2782_CR2","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1016\/j.neuroimage.2010.04.102","volume":"52","author":"E Arponen","year":"2010","unstructured":"Arponen E, Helin S, Marjam\u00e4ki P, Gr\u00f6nroos T, N\u00e5gren K, Ingman K, et al. Radiosynthesis of a new alpha-2C-adrenoceptor tracer [11C]ORM-13070 and its preclinical evaluation in rats [abstract]. NeuroImage. 2010;52:S125.","journal-title":"NeuroImage"},{"key":"2782_CR3","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/sj.bjp.0703882","volume":"132","author":"J Scheibner","year":"2001","unstructured":"Scheibner J, Trendelenburg AU, Hein L, Starke K. Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice. Br J Pharmacol. 2001;132:925\u201333.","journal-title":"Br J Pharmacol"},{"key":"2782_CR4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuint.2007.06.036","volume":"51","author":"AE Knaus","year":"2007","unstructured":"Knaus AE, Muthig V, Schickinger S, Moura E, Beetz N, Gilsbach R, et al. Alpha2-adrenoceptor subtypes \u2013 unexpected functions for receptors and ligands derived from gene-targeted mouse models. Neurochem Int. 2007;51:277\u201381.","journal-title":"Neurochem Int"},{"key":"2782_CR5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0306-4522(02)00966-1","volume":"117","author":"M Holmberg","year":"2003","unstructured":"Holmberg M, Fagerholm V, Scheinin M. Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpessing the alpha(2C)-subtype: an autoradiographic study with [3H]RX821002 and [3H]rauwolscine. Neuroscience. 2003;117:875\u201398.","journal-title":"Neuroscience"},{"key":"2782_CR6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/cne.903280409","volume":"328","author":"AP Nicholas","year":"1993","unstructured":"Nicholas AP, Pieribone V, H\u00f6kfelt T. Distributions of mRNAs for alpha2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol. 1993;328:575\u201394.","journal-title":"J Comp Neurol"},{"key":"2782_CR7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0169-328X(94)90386-7","volume":"21","author":"M Scheinin","year":"1994","unstructured":"Scheinin M, Lomasney JW, Hayden-Hixson DM, Schambra UB, Caron MG, Lefkowitz RJ, et al. Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. Brain Res Mol Brain Res. 1994;21:133\u201349.","journal-title":"Brain Res Mol Brain Res"},{"key":"2782_CR8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejphar.2004.06.065","volume":"497","author":"V Fagerholm","year":"2004","unstructured":"Fagerholm V, Philipp M, Hein L, Scheinin M. [Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography \u2013 validation in alpha2-adrenoceptor knockout mice. Eur J Pharmacol. 2004;497:301\u20139.","journal-title":"Eur J Pharmacol"},{"key":"2782_CR9","doi-asserted-by":"crossref","unstructured":"Arponen E, Helin S, Marjam\u00e4ki P, Gr\u00f6nroos T, Holm P, L\u00f6yttyniemi E, N\u00e5gren K, Scheinin M, Haaparanta-Solin M, Sallinen J, Solin O. A PET tracer for brain \u03b12C-adrenoceptors, 11C-ORM-13070: radiosynthesis and preclinical evaluation in rats and knockout mice. J Nucl Med. 2014. doi: 10.2967\/jnumed.113.135574 .","DOI":"10.2967\/jnumed.113.135574"},{"key":"2782_CR10","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00259-007-0493-3","volume":"34","author":"M Ter\u00e4s","year":"2007","unstructured":"Ter\u00e4s M, Tolvanen T, Johansson JJ, Williams JJ, Knuuti J. Performance of the new generation of whole-body PET\/CT scanners: Discovery STE and Discovery VCT. Eur J Nucl Med Mol Imaging. 2007;34:1683\u201392.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2782_CR11","doi-asserted-by":"crossref","unstructured":"Valentin J, editor. ICRP Publication 89: Basic anatomical and physiological data for use in radiological protection: reference values. Oxford: Pergamon; 2002.","DOI":"10.1016\/S0146-6453(03)00002-2"},{"key":"2782_CR12","first-page":"1023","volume":"46","author":"MG Stabin","year":"2005","unstructured":"Stabin MG, Sparks RB, Crowe EB. OLINDA\/EXM: the second generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023\u20137.","journal-title":"J Nucl Med"},{"key":"2782_CR13","unstructured":"Siegel JA, Thomas SR, Stubbs JB, Stabin MG, Hays MT, Koral KF, et al. MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nucl Med. 1999;40 Suppl:37S\u201361S."},{"key":"2782_CR14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.jcbfm.9600339","volume":"27","author":"AJ Montgomery","year":"2007","unstructured":"Montgomery AJ, Asselin MC, Farde L, Grasby PM. Measurement of methylphenidate-induced change in extrastriatal dopamine concentration using [11C]FLB 457 PET. J Cereb Blood Flow Metab. 2007;27:369\u201377.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2782_CR15","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/syn.20520","volume":"62","author":"V Fagerholm","year":"2008","unstructured":"Fagerholm V, Rokka J, Nyman L, Sallinen J, Tiihonen J, Tupala E, et al. Autoradiographic characterization of alpha(2C)-adrenoceptors in the human striatum. Synapse. 2008;62:508\u201315.","journal-title":"Synapse"},{"key":"2782_CR16","volume-title":"Radiation dose to patients from radiopharmaceuticals. Addendum 6 to ICRP Publication 53","author":"International Commission on Radiological Protection","year":"2002","unstructured":"International Commission on Radiological Protection. Radiation dose to patients from radiopharmaceuticals. Addendum 6 to ICRP Publication 53. Oxford: Pergamon; 2002."}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-014-2782-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-014-2782-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-014-2782-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:24:23Z","timestamp":1649010263000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-014-2782-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,17]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["2782"],"URL":"https:\/\/doi.org\/10.1007\/s00259-014-2782-y","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,17]]}}}