{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:46:48Z","timestamp":1793094408069,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["PGF 2009-4344"],"award-info":[{"award-number":["PGF 2009-4344"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["STW BGT11272"],"award-info":[{"award-number":["STW BGT11272"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["2012-306890"],"award-info":[{"award-number":["2012-306890"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00259-018-4028-x","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T08:00:54Z","timestamp":1524643254000},"page":"1915-1925","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["The best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes"],"prefix":"10.1007","volume":"45","author":[{"given":"G. H.","family":"KleinJan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"van Werkhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. S.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Karakullukcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J. M. A. A.","family":"Zijlmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"van der Hage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"van de Wiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Buckle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M. C.","family":"Klop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Horenblas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Vald\u00e9s Olmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. G.","family":"van der Poel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. W. B.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"4028_CR1","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1056\/NEJMoa060992","volume":"355","author":"DL Morton","year":"2006","unstructured":"Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Elashoff R, Essner R, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006;355:1307\u201317.","journal-title":"N Engl J Med"},{"key":"4028_CR2","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1056\/NEJMoa012782","volume":"349","author":"U Veronesi","year":"2003","unstructured":"Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349:546\u201353.","journal-title":"N Engl J Med"},{"key":"4028_CR3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1053\/j.semdp.2011.08.001","volume":"29","author":"S Horenblas","year":"2012","unstructured":"Horenblas S. Sentinel lymph node biopsy in penile carcinoma. Semin Diagn Pathol. 2012;29:90\u20135.","journal-title":"Semin Diagn Pathol"},{"key":"4028_CR4","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.eururo.2016.09.007","volume":"71","author":"EMK Wit","year":"2017","unstructured":"Wit EMK, Acar C, Grivas N, Yuan C, Horenblas S, Liedberg F, et al. Sentinel node procedure in prostate cancer: a systematic review to assess diagnostic accuracy. Eur Urol. 2017;71:596\u2013605.","journal-title":"Eur Urol"},{"key":"4028_CR5","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.eururo.2014.07.014","volume":"66","author":"GH KleinJan","year":"2014","unstructured":"KleinJan GH, van den Berg NS, Brouwer OR, de Jong J, Acar C, Wit EM, et al. Optimisation of fluorescence guidance during robot-assisted laparoscopic sentinel node biopsy for prostate cancer. Eur Urol. 2014;66:991\u20138.","journal-title":"Eur Urol"},{"key":"4028_CR6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1053\/j.semnuclmed.2010.12.004","volume":"41","author":"S Heller","year":"2011","unstructured":"Heller S, Zanzonico P. Nuclear probes and intraoperative gamma cameras. Semin Nucl Med. 2011;41:166\u201381.","journal-title":"Semin Nucl Med"},{"key":"4028_CR7","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s10434-001-0538-y","volume":"8","author":"OE Nieweg","year":"2001","unstructured":"Nieweg OE, Tanis PJ, Kroon BB. The definition of a sentinel node. Ann Surg Oncol. 2001;8:538\u201341.","journal-title":"Ann Surg Oncol"},{"key":"4028_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1245\/ASO.2003.06.007","volume":"10","author":"C Chao","year":"2003","unstructured":"Chao C, Wong SL, Edwards MJ, Ross MI, Reintgen DS, Noyes RD, et al. Sentinel lymph node biopsy for head and neck melanomas. Ann Surg Oncol. 2003;10:21\u20136.","journal-title":"Ann Surg Oncol"},{"key":"4028_CR9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/jjco\/29.12.604","volume":"29","author":"K Motomura","year":"1999","unstructured":"Motomura K, Inaji H, Komoike Y, Kasugai T, Noguchi S, Koyama H. Sentinel node biopsy guided by indocyanine green dye in breast cancer patients. Jpn J Clin Oncol. 1999;29:604\u20137.","journal-title":"Jpn J Clin Oncol"},{"key":"4028_CR10","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1007\/s00259-016-3372-y","volume":"43","author":"GH KleinJan","year":"2016","unstructured":"KleinJan GH, Bunschoten A, van den Berg NS, Olmos RA, Klop WM, Horenblas S, et al. Fluorescence guided surgery and tracer-dose, fact or fiction? Eur J Nucl Med Mol Imaging. 2016;43:1857\u201367.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4028_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1148\/radiol.2015132698","volume":"276","author":"FW Leeuwen van","year":"2015","unstructured":"van Leeuwen FW, Hardwick JC, van Erkel AR. Luminescence-based imaging approaches in the field of interventional molecular imaging. Radiology. 2015;276:12\u201329.","journal-title":"Radiology"},{"key":"4028_CR12","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.2967\/jnumed.112.103127","volume":"53","author":"OR Brouwer","year":"2012","unstructured":"Brouwer OR, Buckle T, Vermeeren L, Klop WM, Balm AJ, van der Poel HG, et al. Comparing the hybrid fluorescent-radioactive tracer indocyanine green-99mTc-nanocolloid with 99mTc-nanocolloid for sentinel node identification: a validation study using lymphoscintigraphy and SPECT\/CT. J Nucl Med. 2012;53:1034\u201340.","journal-title":"J Nucl Med"},{"key":"4028_CR13","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.eururo.2013.11.014","volume":"65","author":"OR Brouwer","year":"2014","unstructured":"Brouwer OR, van den Berg NS, Matheron HM, van der Poel HG, van Rhijn BW, Bex A, et al. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye. Eur Urol. 2014;65:600\u20139.","journal-title":"Eur Urol"},{"key":"4028_CR14","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.ygyno.2013.09.007","volume":"131","author":"HM Matheron","year":"2013","unstructured":"Matheron HM, van den Berg NS, Brouwer OR, Kleinjan GH, van Driel WJ, Trum JW, et al. Multimodal surgical guidance towards the sentinel node in vulvar cancer. Gynecol Oncol. 2013;131:720\u20135.","journal-title":"Gynecol Oncol"},{"key":"4028_CR15","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1007\/s00259-012-2129-5","volume":"39","author":"NS Berg van den","year":"2012","unstructured":"van den Berg NS, Brouwer OR, Klop WM, Karakullukcu B, Zuur CL, Tan IB, et al. Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-(99m)Tc-nanocolloid. Eur J Nucl Med Mol Imaging. 2012;39:1128\u201336.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4028_CR16","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1148\/radiol.14140322","volume":"275","author":"NS Berg van den","year":"2015","unstructured":"van den Berg NS, Brouwer OR, Schaafsma BE, Matheron HM, Klop WM, Balm AJ, et al. Multimodal surgical guidance during sentinel node biopsy for melanoma: combined gamma tracing and fluorescence imaging of the sentinel node through use of the hybrid tracer indocyanine green-(99m)Tc-Nanocolloid. Radiology. 2015;275:521\u20139.","journal-title":"Radiology"},{"key":"4028_CR17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250:187\u201396.","journal-title":"Ann Surg"},{"key":"4028_CR18","doi-asserted-by":"publisher","first-page":"169S","DOI":"10.1245\/ASO.2004.12.911","volume":"11","author":"OE Nieweg","year":"2004","unstructured":"Nieweg OE, Estourgie SH. What is a sentinel node and what is a false-negative sentinel node? Ann Surg Oncol. 2004;11:169S\u201373S.","journal-title":"Ann Surg Oncol"},{"key":"4028_CR19","doi-asserted-by":"crossref","unstructured":"Harrel FE. Regression modeling strategies with applications to linear models, survival analysis and logistic regression. Spinger International Publishing; 2001.","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"4028_CR20","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1200\/JCO.2010.33.1884","volume":"29","author":"ME Valsecchi","year":"2011","unstructured":"Valsecchi ME, Silbermins D, de Rosa N, Wong SL, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in patients with melanoma: a meta-analysis. J Clin Oncol. 2011;29:1479\u201387.","journal-title":"J Clin Oncol"},{"key":"4028_CR21","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.oraloncology.2014.07.020","volume":"50","author":"GB Flach","year":"2014","unstructured":"Flach GB, Bloemena E, Klop WM, van Es RJ, Schepman KP, Hoekstra OS, et al. Sentinel lymph node biopsy in clinically N0 T1-T2 staged oral cancer: the Dutch multicenter trial. Oral Oncol. 2014;50:1020\u20134.","journal-title":"Oral Oncol"},{"key":"4028_CR22","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.1245\/s10434-011-2207-0","volume":"19","author":"T Pezier","year":"2012","unstructured":"Pezier T, Nixon IJ, Gurney B, Schilling C, Hussain K, Lyons AJ, et al. Sentinel lymph node biopsy for T1\/T2 oral cavity squamous cell carcinoma--a prospective case series. Ann Surg Oncol. 2012;19:3528\u201333.","journal-title":"Ann Surg Oncol"},{"key":"4028_CR23","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0022-5347(05)64835-5","volume":"168","author":"PJ Tanis","year":"2002","unstructured":"Tanis PJ, Lont AP, Meinhardt W, Olmos RA, Nieweg OE, Horenblas S. Dynamic sentinel node biopsy for penile cancer: reliability of a staging technique. J Urol. 2002;168:76\u201380.","journal-title":"J Urol"},{"key":"4028_CR24","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1200\/jco.2008.26.15_suppl.20549","volume":"26","author":"AG Zee Van der","year":"2008","unstructured":"Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, et al. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol. 2008;26:884\u20139.","journal-title":"J Clin Oncol"},{"key":"4028_CR25","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.eururo.2013.11.017","volume":"65","author":"TB Manny","year":"2014","unstructured":"Manny TB, Patel M, Hemal AK. Fluorescence-enhanced robotic radical prostatectomy using real-time lymphangiography and tissue marking with percutaneous injection of unconjugated indocyanine green: the initial clinical experience in 50 patients. Eur Urol. 2014;65:1162\u20138.","journal-title":"Eur Urol"},{"key":"4028_CR26","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1245\/s10434-016-5186-3","volume":"23","author":"NS Berg van den","year":"2016","unstructured":"van den Berg NS, Miwa M, KleinJan GH, Sato T, Maeda Y, van Akkooi AC, et al. (Near-infrared) fluorescence-guided surgery under ambient light conditions: a next step to embedment of the technology in clinical routine. Ann Surg Oncol. 2016;23:2586\u201395.","journal-title":"Ann Surg Oncol"},{"key":"4028_CR27","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/CMR.0000000000000271","volume":"26","author":"IM Ploeg van der","year":"2016","unstructured":"van der Ploeg IM, Madu MF, van der Hage JA, Wouters MW, Klop WM, van der Hiel B, et al. Blue dye can be safely omitted in most sentinel node procedures for melanoma. Melanoma Res. 2016;26:464\u20138.","journal-title":"Melanoma Res"},{"key":"4028_CR28","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/01.sla.0000181092.50141.fa","volume":"242","author":"DL Morton","year":"2005","unstructured":"Morton DL, Cochran AJ, Thompson JF, Elashoff R, Essner R, Glass EC, et al. Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg. 2005;242:302\u201311, discussion 11\u201313","journal-title":"Ann Surg"},{"key":"4028_CR29","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.2967\/jnumed.111.098517","volume":"53","author":"T Buckle","year":"2012","unstructured":"Buckle T, Brouwer OR, Valdes Olmos RA, van der Poel HG, van Leeuwen FW. Relationship between intraprostatic tracer deposits and sentinel lymph node mapping in prostate cancer patients. J Nucl Med. 2012;53:1026\u201333.","journal-title":"J Nucl Med"},{"key":"4028_CR30","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1097\/SLA.0b013e3181724f5e","volume":"247","author":"RZ Karim","year":"2008","unstructured":"Karim RZ, Scolyer RA, Li W, Yee VS, McKinnon JG, Li LX, et al. False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology. Ann Surg. 2008;247:1003\u201310.","journal-title":"Ann Surg"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-018-4028-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-018-4028-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-018-4028-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T23:08:15Z","timestamp":1661036895000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-018-4028-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["4028"],"URL":"https:\/\/doi.org\/10.1007\/s00259-018-4028-x","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"11 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}