{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:18:23Z","timestamp":1793366303383,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T00:00:00Z","timestamp":1534550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00259-018-4119-8","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T15:53:04Z","timestamp":1534607584000},"page":"396-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue"],"prefix":"10.1007","volume":"46","author":[{"given":"Michel","family":"Koole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"van Aalst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Devrome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Serdons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lacroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sciberras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,18]]},"reference":[{"key":"4119_CR1","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.1523\/JNEUROSCI.14-09-05223.1994","volume":"14","author":"SM Bajjalieh","year":"1994","unstructured":"Bajjalieh SM, Frantz GD, Weimann JM, McConnell SK, Scheller RH. Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci. 1994;14:5223\u201335.","journal-title":"J Neurosci"},{"key":"4119_CR2","doi-asserted-by":"publisher","first-page":"348ra96","DOI":"10.1126\/scitranslmed.aaf6667","volume":"8","author":"SJ Finnema","year":"2016","unstructured":"Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, et al. Imaging synaptic density in the living human brain. Sci Transl Med. 2016;8:348ra96. \n                    https:\/\/doi.org\/10.1126\/scitranslmed.aaf6667\n                    \n                  .","journal-title":"Sci Transl Med"},{"key":"4119_CR3","doi-asserted-by":"publisher","first-page":"777","DOI":"10.2967\/jnumed.115.168179","volume":"57","author":"NB Nabulsi","year":"2016","unstructured":"Nabulsi NB, Mercier J, Holden D, Carre S, Najafzadeh S, Vandergeten MC, et al. Synthesis and preclinical evaluation of [11C]UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain. J Nucl Med. 2016;57:777\u201384. \n                    https:\/\/doi.org\/10.2967\/jnumed.115.168179\n                    \n                  .","journal-title":"J Nucl Med"},{"key":"4119_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/nan.12054","volume":"40","author":"J Crevecoeur","year":"2014","unstructured":"Crevecoeur J, Kaminski RM, Rogister B, Foerch P, Vandenplas C, Neveux M, et al. Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis. Neuropathol Appl Neurobiol. 2014;40:191\u2013204. \n                    https:\/\/doi.org\/10.1111\/nan.12054\n                    \n                  .","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4119_CR5","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s12031-009-9288-2","volume":"39","author":"G Feng","year":"2009","unstructured":"Feng G, Xiao F, Lu Y, Huang Z, Yuan J, Xiao Z, et al. Down-regulation synaptic vesicle protein 2A in the anterior temporal neocortex of patients with intractable epilepsy. J Mol Neurosci. 2009;39:354\u20139. \n                    https:\/\/doi.org\/10.1007\/s12031-009-9288-2\n                    \n                  .","journal-title":"J Mol Neurosci"},{"issue":"Pt 1","key":"4119_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/brain\/123.1.19","volume":"123","author":"EA Proper","year":"2000","unstructured":"Proper EA, Oestreicher AB, Jansen GH, Veelen CW, van Rijen PC, Gispen WH, et al. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain J Neurol. 2000;123(Pt 1):19\u201330.","journal-title":"Brain J Neurol"},{"key":"4119_CR7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/ana.410270502","volume":"27","author":"ST DeKosky","year":"1990","unstructured":"DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity. Ann Neurol. 1990;27:457\u201364. \n                    https:\/\/doi.org\/10.1002\/ana.410270502\n                    \n                  .","journal-title":"Ann Neurol"},{"key":"4119_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1212\/WNL.39.3.355","volume":"39","author":"JE Hamos","year":"1989","unstructured":"Hamos JE, DeGennaro LJ, Drachman DA. Synaptic loss in Alzheimer\u2019s disease and other dementias. Neurology. 1989;39:355\u201361.","journal-title":"Neurology"},{"key":"4119_CR9","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","volume":"83","author":"G Tang","year":"2014","unstructured":"Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 2014;83:1131\u201343. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2014.07.040\n                    \n                  .","journal-title":"Neuron"},{"key":"4119_CR10","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/nm.2886","volume":"18","author":"H Kang","year":"2012","unstructured":"Kang H, Voleti B, Hajszan T, Rajkowska G, Stockmeier C, Licznerski P, et al. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat Med. 2012;18:1413\u20137. \n                    https:\/\/doi.org\/10.1038\/nm.2886\n                    \n                  .","journal-title":"Nat Med"},{"key":"4119_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","volume":"57","author":"LA Glantz","year":"2000","unstructured":"Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry. 2000;57:65\u201373.","journal-title":"Arch Gen Psychiatry"},{"key":"4119_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","volume":"530","author":"A Sekar","year":"2016","unstructured":"Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530:177\u201383. \n                    https:\/\/doi.org\/10.1038\/nature16549\n                    \n                  .","journal-title":"Nature"},{"key":"4119_CR13","first-page":"631","volume":"58","author":"M Lubberink","year":"2017","unstructured":"Lubberink M, Appel L, Daging J, Lindskog K, Danfors T, Larsson E-M, et al. Tracer kinetic analysis of the SV2A ligand [11C]UCB-a as a PET marker for synaptic density in humans. J Nucl Med. 2017;58:631.","journal-title":"J Nucl Med"},{"key":"4119_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s11307-014-0820-6","volume":"17","author":"F Bretin","year":"2015","unstructured":"Bretin F, Bahri MA, Bernard C, Warnock G, Aerts J, Mestdagh N, et al. Biodistribution and radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H: first-in-human study. Mol Imaging Biol. 2015;17:557\u201364. \n                    https:\/\/doi.org\/10.1007\/s11307-014-0820-6\n                    \n                  .","journal-title":"Mol Imaging Biol"},{"key":"4119_CR15","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/00004647-199609000-00008","volume":"16","author":"J Logan","year":"1996","unstructured":"Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 1996;16:834\u201340. \n                    https:\/\/doi.org\/10.1097\/00004647-199609000-00008\n                    \n                  .","journal-title":"J Cereb Blood Flow Metab"},{"key":"4119_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/jcbfm.2009.190","volume":"30","author":"VJ Cunningham","year":"2010","unstructured":"Cunningham VJ, Rabiner EA, Slifstein M, Laruelle M, Gunn RN. Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited. J Cereb Blood Flow Metab. 2010;30:46\u201350. \n                    https:\/\/doi.org\/10.1038\/jcbfm.2009.190\n                    \n                  .","journal-title":"J Cereb Blood Flow Metab"},{"key":"4119_CR17","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1097\/01.wcb.0000033967.83623.34","volume":"22","author":"Y Wu","year":"2002","unstructured":"Wu Y, Carson RE. Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging. J Cereb Blood Flow Metab. 2002;22:1440\u201352. \n                    https:\/\/doi.org\/10.1097\/01.wcb.0000033967.83623.34\n                    \n                  .","journal-title":"J Cereb Blood Flow Metab"},{"key":"4119_CR18","doi-asserted-by":"publisher","unstructured":"Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, et al. Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. J Cereb Blood Flow Metab. 2017:271678x17724947. \n                    https:\/\/doi.org\/10.1177\/0271678x17724947\n                    \n                  .","DOI":"10.1177\/0271678x17724947"},{"key":"4119_CR19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.zemedi.2009.05.003","volume":"19","author":"P Kletting","year":"2009","unstructured":"Kletting P, Glatting G. Model selection for time-activity curves: the corrected Akaike information criterion and the F-test. Z Med Phys. 2009;19:200\u20136.","journal-title":"Z Med Phys"},{"key":"4119_CR20","doi-asserted-by":"publisher","first-page":"4285","DOI":"10.1118\/1.2794176","volume":"34","author":"G Glatting","year":"2007","unstructured":"Glatting G, Kletting P, Reske SN, Hohl K, Ring C. Choosing the optimal fit function: comparison of the Akaike information criterion and the F-test. Med Phys. 2007;34:4285\u201392. \n                    https:\/\/doi.org\/10.1118\/1.2794176\n                    \n                  .","journal-title":"Med Phys"},{"key":"4119_CR21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40658-017-0197-0","volume":"4","author":"SSV Golla","year":"2017","unstructured":"Golla SSV, Adriaanse SM, Yaqub M, Windhorst AD, Lammertsma AA, van Berckel BNM, et al. Model selection criteria for dynamic brain PET studies. EJNMMI Phys. 2017;4:30. \n                    https:\/\/doi.org\/10.1186\/s40658-017-0197-0\n                    \n                  .","journal-title":"EJNMMI Phys"},{"key":"4119_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13550-017-0265-4","volume":"7","author":"IL Alves","year":"2017","unstructured":"Alves IL, Vallez Garcia D, Parente A, Doorduin J, Dierckx R, Marques da Silva AM, et al. Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain. EJNMMI Res. 2017;7:17. \n                    https:\/\/doi.org\/10.1186\/s13550-017-0265-4\n                    \n                  .","journal-title":"EJNMMI Res"},{"key":"4119_CR23","first-page":"2083","volume":"41","author":"M Slifstein","year":"2000","unstructured":"Slifstein M, Laruelle M. Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med. 2000;41:2083\u20138.","journal-title":"J Nucl Med"},{"key":"4119_CR24","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00259-009-1293-8","volume":"37","author":"K-P Wong","year":"2010","unstructured":"Wong K-P, Wardak M, Shao W, Dahlbom M, Kepe V, Liu J, et al. Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region. Eur J Nucl Med Mol Imaging. 2010;37:575\u201388. \n                    https:\/\/doi.org\/10.1007\/s00259-009-1293-8\n                    \n                  .","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4119_CR25","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.2967\/jnumed.112.118679","volume":"54","author":"K Laere Van","year":"2013","unstructured":"Van Laere K, Ahmad RU, Hudyana H, Dubois K, Schmidt ME, Celen S, et al. Quantification of [18F]JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain. J Nucl Med. 2013;54:1285\u201393. \n                    https:\/\/doi.org\/10.2967\/jnumed.112.118679\n                    \n                  .","journal-title":"J Nucl Med"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-018-4119-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-018-4119-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-018-4119-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T23:25:23Z","timestamp":1566084323000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-018-4119-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,18]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["4119"],"URL":"https:\/\/doi.org\/10.1007\/s00259-018-4119-8","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,18]]},"assertion":[{"value":"9 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Brigitte Lacroix, Joel Mercier, David Sciberras and Paul Maguire are employees of UCB Pharma. Michel Koole, June van Aalst, Martijn Devrome, Nathalie Mertens, Kim Serdons and Koen Van Laere have no conflicts to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}