{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:38:40Z","timestamp":1790728720625,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100014392","name":"Avid Radiopharmaceuticals","doi-asserted-by":"crossref","award":["unknown"],"award-info":[{"award-number":["unknown"]}],"id":[{"id":"10.13039\/100014392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alzheimer's Research UK","award":["unknown"],"award-info":[{"award-number":["unknown"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00259-018-4238-2","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T05:55:16Z","timestamp":1545198916000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dual-phase [18F]florbetapir in frontotemporal dementia"],"prefix":"10.1007","volume":"46","author":[{"given":"Michael","family":"Asghar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Herholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-519X","authenticated-orcid":false,"given":"Stephen F.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"4238_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack Jr","year":"2018","unstructured":"Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018;14:535\u201362. \n                    https:\/\/doi.org\/10.1016\/j.jalz.2018.02.018\n                    \n                  .","journal-title":"Alzheimers Dement"},{"key":"4238_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s00259-007-0523-1","volume":"35","author":"H Engler","year":"2008","unstructured":"Engler H, Santillo AF, Wang SX, Lindau M, Savitcheva I, Nordberg A, et al. In vivo amyloid imaging with PET in frontotemporal dementia. Eur J Nucl Med Mol Imaging. 2008;35:100\u20136. \n                    https:\/\/doi.org\/10.1007\/s00259-007-0523-1\n                    \n                  .","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4238_CR3","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.jalz.2012.07.003","volume":"9","author":"R Ossenkoppele","year":"2013","unstructured":"Ossenkoppele R, Prins ND, Pijnenburg YA, Lemstra AW, van der Flier WM, Adriaanse SF, et al. Impact of molecular imaging on the diagnostic process in a memory clinic. Alzheimers Dement. 2013;9:414\u201321. \n                    https:\/\/doi.org\/10.1016\/j.jalz.2012.07.003\n                    \n                  .","journal-title":"Alzheimers Dement"},{"key":"4238_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.dadm.2017.05.005","volume":"9","author":"RH Tan","year":"2017","unstructured":"Tan RH, Kril JJ, Yang Y, Tom N, Hodges JR, Villemagne VL, et al. Assessment of amyloid beta in pathologically confirmed frontotemporal dementia syndromes. Alzheimers Dement. 2017;9:10\u201320. \n                    https:\/\/doi.org\/10.1016\/j.dadm.2017.05.005\n                    \n                  .","journal-title":"Alzheimers Dement"},{"key":"4238_CR5","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.neurobiolaging.2003.10.007","volume":"25","author":"J Diehl","year":"2004","unstructured":"Diehl J, Grimmer T, Drzezga A, Riemenschneider M, Forstl H, Kurz A. Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study. Neurobiol Aging. 2004;25:1051\u20136. \n                    https:\/\/doi.org\/10.1016\/j.neurobiolaging.2003.10.007\n                    \n                  .","journal-title":"Neurobiol Aging"},{"key":"4238_CR6","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2005.11.002","volume":"28","author":"J Diehl-Schmid","year":"2007","unstructured":"Diehl-Schmid J, Grimmer T, Drzezga A, Bornschein S, Riemenschneider M, Forstl H, et al. Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study. Neurobiol Aging. 2007;28:42\u201350. \n                    https:\/\/doi.org\/10.1016\/j.neurobiolaging.2005.11.002\n                    \n                  .","journal-title":"Neurobiol Aging"},{"key":"4238_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1034\/j.1600-0404.2002.1o148.x","volume":"105","author":"AR Varma","year":"2002","unstructured":"Varma AR, Adams W, Lloyd JJ, Carson KJ, Snowden JS, Testa HJ, et al. Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia. Acta Neurol Scand. 2002;105:261\u20139.","journal-title":"Acta Neurol Scand"},{"key":"4238_CR8","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/jnnp.2006.106054","volume":"78","author":"R McNeill","year":"2007","unstructured":"McNeill R, Sare GM, Manoharan M, Testa HJ, Mann DM, Neary D, et al. Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2007;78:350\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4238_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2967\/jnumed.110.082057","volume":"52","author":"AH Rostomian","year":"2011","unstructured":"Rostomian AH, Madison C, Rabinovici GD, Jagust WJ. Early 11C-PIB frames and 18F-FDG PET measures are comparable: a study validated in a cohort of AD and FTLD patients. J Nucl Med. 2011;52:173\u20139. \n                    https:\/\/doi.org\/10.2967\/jnumed.110.082057\n                    \n                  .","journal-title":"J Nucl Med"},{"key":"4238_CR10","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1007\/s00259-016-3426-1","volume":"43","author":"V Garibotto","year":"2016","unstructured":"Garibotto V, Morbelli S, Pagani M. Dual-phase amyloid PET: hitting two birds with one stone. Eur J Nucl Med Mol Imaging. 2016;43:1300\u20133.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4238_CR11","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","volume":"51","author":"D Neary","year":"1998","unstructured":"Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51:1546\u201354.","journal-title":"Neurology"},{"key":"4238_CR12","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34:939\u201344.","journal-title":"Neurology"},{"key":"4238_CR13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8.","volume":"19","author":"TN Tombaugh","year":"2004","unstructured":"Tombaugh TN. Trail making test A and B: normative data stratified by age and education. Arch Clin Neuropsychol : Off J National Acad Neuropsychol. 2004;19:203\u201314. \n                    https:\/\/doi.org\/10.1016\/S0887-6177(03)00039-8.","journal-title":"Arch Clin Neuropsychol : Off J National Acad Neuropsychol"},{"key":"4238_CR14","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1001\/archneur.1992.00530360051017","volume":"49","author":"AU Monsch","year":"1992","unstructured":"Monsch AU, Bondi MW, Butters N, Salmon DP, Katzman R, Thal LJ. Comparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. Arch Neurol. 1992;49:1253\u20138.","journal-title":"Arch Neurol"},{"key":"4238_CR15","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356.","volume":"141","author":"WG Rosen","year":"1984","unstructured":"Rosen WG, Mohs RC. Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984;141:1356\u201364. \n                    https:\/\/doi.org\/10.1176\/ajp.141.11.1356.","journal-title":"Am J Psychiatry"},{"issue":"Suppl 1","key":"4238_CR16","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1017\/S1041610297004870","volume":"9","author":"JC Morris","year":"1997","unstructured":"Morris JC. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr. 1997;9(Suppl 1):173\u20136 discussion 7-8.","journal-title":"Int Psychogeriatr"},{"key":"4238_CR17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.2967\/jnumed.114.147454","volume":"56","author":"C Kobylecki","year":"2015","unstructured":"Kobylecki C, Langheinrich T, Hinz R, Vardy ER, Brown G, Martino ME, et al. 18F-florbetapir PET in patients with frontotemporal dementia and Alzheimer disease. J Nucl Med. 2015;56:386\u201391. \n                    https:\/\/doi.org\/10.2967\/jnumed.114.147454\n                    \n                  .","journal-title":"J Nucl Med"},{"key":"4238_CR18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.neuroimage.2007.06.004","volume":"38","author":"RL Ahsan","year":"2007","unstructured":"Ahsan RL, Allom R, Gousias IS, Habib H, Turkheimer FE, Free S, et al. Volumes, spatial extents and a probabilistic atlas of the human basal ganglia and thalamus. NeuroImage. 2007;38:261\u201370. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2007.06.004\n                    \n                  .","journal-title":"NeuroImage"},{"key":"4238_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/hbm.20254","volume":"28","author":"A Hammers","year":"2007","unstructured":"Hammers A, Chen CH, Lemieux L, Allom R, Vossos S, Free SL, et al. Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space. Hum Brain Mapp. 2007;28:34\u201348. \n                    https:\/\/doi.org\/10.1002\/hbm.20254\n                    \n                  .","journal-title":"Hum Brain Mapp"},{"key":"4238_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/hbm.10123","volume":"19","author":"A Hammers","year":"2003","unstructured":"Hammers A, Allom R, Koepp MJ, Free SL, Myers R, Lemieux L, et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp. 2003;19:224\u201347. \n                    https:\/\/doi.org\/10.1002\/hbm.10123\n                    \n                  .","journal-title":"Hum Brain Mapp"},{"key":"4238_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.neuroimage.2006.09.011","volume":"34","author":"R Casanova","year":"2007","unstructured":"Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, et al. Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. NeuroImage. 2007;34:137\u201343. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2006.09.011\n                    \n                  .","journal-title":"NeuroImage"},{"key":"4238_CR22","doi-asserted-by":"publisher","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","volume":"8","author":"M Xia","year":"2013","unstructured":"Xia M, Wang J, He Y. BrainNet viewer: a network visualization tool for human brain connectomics. PLoS One. 2013;8:e68910. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0068910\n                    \n                  .","journal-title":"PLoS One"},{"key":"4238_CR23","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"JM Bland","year":"1986","unstructured":"Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1:307\u201310.","journal-title":"Lancet"},{"key":"4238_CR24","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00259-011-2051-2","volume":"39","author":"IT Hsiao","year":"2012","unstructured":"Hsiao IT, Huang CC, Hsieh CJ, Hsu WC, Wey SP, Yen TC, et al. Correlation of early-phase 18F-florbetapir (AV-45\/Amyvid) PET images to FDG images: preliminary studies. Eur J Nucl Med Mol Imaging. 2012;39:613\u201320. \n                    https:\/\/doi.org\/10.1007\/s00259-011-2051-2\n                    \n                  .","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4238_CR25","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1007\/s00330-014-3311-x","volume":"24","author":"L Fu","year":"2014","unstructured":"Fu L, Liu L, Zhang J, Xu B, Fan Y, Tian J. Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis. Eur Radiol. 2014;24:2800\u20139. \n                    https:\/\/doi.org\/10.1007\/s00330-014-3311-x\n                    \n                  .","journal-title":"Eur Radiol"},{"key":"4238_CR26","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1212\/WNL.0b013e31823b9c5e","volume":"77","author":"GD Rabinovici","year":"2011","unstructured":"Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, et al. Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology. 2011;77:2034\u201342. \n                    https:\/\/doi.org\/10.1212\/WNL.0b013e31823b9c5e\n                    \n                  .","journal-title":"Neurology"},{"key":"4238_CR27","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.3233\/JAD-160285.","volume":"53","author":"EG Vijverberg","year":"2016","unstructured":"Vijverberg EG, Wattjes MP, Dols A, Krudop WA, Moller C, Peters A, et al. Diagnostic accuracy of MRI and additional [18F]FDG-PET for behavioral variant frontotemporal dementia in patients with late onset behavioral changes. J Alzheimer's Dis : JAD. 2016;53:1287\u201397. \n                    https:\/\/doi.org\/10.3233\/JAD-160285.","journal-title":"J Alzheimer's Dis : JAD"},{"key":"4238_CR28","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1177\/1533317514524811","volume":"29","author":"BJ Kerklaan","year":"2014","unstructured":"Kerklaan BJ, van Berckel BN, Herholz K, Dols A, van der Flier WM, Scheltens P, et al. The added value of 18-fluorodeoxyglucose-positron emission tomography in the diagnosis of the behavioral variant of frontotemporal dementia. Am J Alzheimer's Dis Demen. 2014;29:607\u201313. \n                    https:\/\/doi.org\/10.1177\/1533317514524811\n                    \n                  .","journal-title":"Am J Alzheimer's Dis Demen"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-018-4238-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-018-4238-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-018-4238-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T19:08:07Z","timestamp":1576696087000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-018-4238-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["4238"],"URL":"https:\/\/doi.org\/10.1007\/s00259-018-4238-2","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]},"assertion":[{"value":"5 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human rights"}}]}}