{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:13:04Z","timestamp":1764364384130,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010454","name":"Bracco Diagnostics","doi-asserted-by":"publisher","award":["IIS-US-0107"],"award-info":[{"award-number":["IIS-US-0107"]}],"id":[{"id":"10.13039\/501100010454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00259-019-04278-8","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T14:09:50Z","timestamp":1551190190000},"page":"1226-1239","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The impact of revascularization on myocardial blood flow as assessed by positron emission tomography"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-4442","authenticated-orcid":false,"given":"Robert M.","family":"Bober","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard V.","family":"Milani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet A.","family":"Oktay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichole M.","family":"Polin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Morin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"4278_CR1","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/j.jacc.2014.07.017","volume":"64","author":"SD Fihn","year":"2014","unstructured":"Fihn SD, Blankenship JC, Alexander KP, Bittl JA, Byrne JG, Fletcher BJ, et al. 2014 ACC\/AHA\/AATS\/PCNA\/SCAI\/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2014;64:1929\u201349.","journal-title":"J Am Coll Cardiol"},{"key":"4278_CR2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jcmg.2011.12.014","volume":"5","author":"NP Johnson","year":"2012","unstructured":"Johnson NP, Gould KL. Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severity. JACC Cardiovasc imaging. 2012;5:430\u201340.","journal-title":"JACC Cardiovasc imaging"},{"key":"4278_CR3","doi-asserted-by":"crossref","unstructured":"Gould KL, Johnson NP, Roby A, Nguyen tung T, Kirkeeide RL, Haynie M, et al. Regional artery specific thresholds of quantitative myocardial perfusion by PET associated with reduced MI and death after revascularization in stable CAD. J Nucl Med. 2018;jnumed.118.211953.","DOI":"10.2967\/jnumed.118.211953"},{"key":"4278_CR4","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1056\/NEJMoa070829","volume":"356","author":"WE Boden","year":"2007","unstructured":"Boden WE, O\u2019Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, et al. COURAGE: optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356:1503\u201316.","journal-title":"N Engl J Med"},{"key":"4278_CR5","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1056\/NEJMoa1205361","volume":"367","author":"B Bruyne De","year":"2012","unstructured":"De Bruyne B, Pijls NHJ, Kalesan B, Barbato E, Tonino PAL, Piroth Z, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367:991\u20131001.","journal-title":"N Engl J Med"},{"key":"4278_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1056\/NEJMoa0807611","volume":"360","author":"PAL Tonino","year":"2009","unstructured":"Tonino PAL, De Bruyne B, Pijls NHJ, Siebert U, Ikeno F, Van\u2019t Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213\u201324.","journal-title":"N Engl J Med"},{"key":"4278_CR7","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jcmg.2016.09.019","volume":"10","author":"D Kitkungvan","year":"2017","unstructured":"Kitkungvan D, Johnson NP, Roby AE, Patel MB, Kirkeeide R, Gould KL. Routine clinical quantitative rest stress myocardial perfusion for managing coronary artery disease. JACC Cardiovasc Imaging. 2017;10:565\u201377.","journal-title":"JACC Cardiovasc Imaging"},{"key":"4278_CR8","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.jcmg.2011.06.015","volume":"4","author":"NP Johnson","year":"2011","unstructured":"Johnson NP, Gould KL. Physiological basis for angina and ST-segment change: PET-verified thresholds of quantitative stress myocardial perfusion and coronary flow reserve. JACC Cardiovasc Imaging. 2011;4:990\u20138.","journal-title":"JACC Cardiovasc Imaging"},{"key":"4278_CR9","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.jacc.2013.07.076","volume":"62","author":"KL Gould","year":"2013","unstructured":"Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober RM, et al. Anatomic versus physiologic assessment of coronary artery disease. Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639\u201353.","journal-title":"J Am Coll Cardiol"},{"key":"4278_CR10","first-page":"553","volume-title":"Hurst\u2019s the heart","author":"KL Gould","year":"2017","unstructured":"Gould KL, Schelbert HR, Narula J. Positron emission tomography in heart disease. In: Fuster V, Harrington RA, Narula J, Eapen ZJ, editors. Hurst\u2019s the heart. New York: McGraw-Hill; 2017. p. 553\u201383."},{"key":"4278_CR11","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.jcin.2015.05.032","volume":"8","author":"TP Hoef van de","year":"2015","unstructured":"van de Hoef TP, Echavarr\u00eda-Pinto M, Van Lavieren MA, Meuwissen M, Serruys PW, Tijssen JGP, et al. Diagnostic and prognostic implications of coronary flow capacity: a comprehensive cross-modality physiological concept in ischemic heart disease. JACC Cardiovasc Interv. 2015;8:1670\u201380.","journal-title":"JACC Cardiovasc Interv"},{"key":"4278_CR12","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s12350-016-0442-2","volume":"24","author":"RM Bober","year":"2017","unstructured":"Bober RM, Thompson CD, Morin DP. The effect of coronary revascularization on regional myocardial blood flow as assessed by stress positron emission tomography. J Nucl Cardiol. 2017;24:961\u201374.","journal-title":"J Nucl Cardiol"},{"key":"4278_CR13","first-page":"1701","volume":"37","author":"K Yoshida","year":"1996","unstructured":"Yoshida K, Mullani NA, Gould KL. Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia. J Nucl Med. 1996;37:1701\u201312.","journal-title":"J Nucl Med"},{"key":"4278_CR14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001715","volume":"8","author":"SS Nijjer","year":"2015","unstructured":"Nijjer SS, Petraco R, van de Hoef TP, Sen S, van Lavieren MA, Foale RA, et al. Change in coronary blood flow after PCI in relation to baseline lesion physiology: results of the JUSTIFY-PCI study. Circ Cardiovasc Interv. 2015;8:e001715.","journal-title":"Circ Cardiovasc Interv"},{"key":"4278_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jcmg.2011.09.020","volume":"5","author":"NP Johnson","year":"2012","unstructured":"Johnson NP, Kirkeeide RL, Gould KL. Is discordance of coronary flow reserve and fractional flow reserve due to methodology or clinically relevant coronary pathophysiology? JACC Cardiovasc imaging. 2012;5:193\u2013202.","journal-title":"JACC Cardiovasc imaging"},{"key":"4278_CR16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007417","volume":"11","author":"RS Driessen","year":"2018","unstructured":"Driessen RS, Danad I, Stuijfzand WJ, Schumacher SP, Knuuti J, M\u00e4ki M, et al. Impact of revascularization on absolute myocardial blood flow as assessed by serial [15O]H2O positron emission tomography imaging. Circ Cardiovasc Imaging. 2018;11:e007417.","journal-title":"Circ Cardiovasc Imaging"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00259-019-04278-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-019-04278-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-019-04278-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T17:06:22Z","timestamp":1663002382000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00259-019-04278-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,26]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["4278"],"URL":"https:\/\/doi.org\/10.1007\/s00259-019-04278-8","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"type":"print","value":"1619-7070"},{"type":"electronic","value":"1619-7089"}],"subject":[],"published":{"date-parts":[[2019,2,26]]},"assertion":[{"value":"18 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"R.M. Bober has received research grants and is a consultant for Bracco Diagnostics, and is also a consultant for and on the advisory board of Ionetix Corporation.All other authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional and\/or national research committee and with the principles of the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}