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Cerenkov luminescence imaging (CLI) using\n                      <jats:sup>68<\/jats:sup>\n                      Ga-prostate-specific membrane antigen (\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA) is a novel technique for intraoperative margin assessment. The aim of this first-in-man study was to investigate the feasibility of intraoperative\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA CLI\n                      <jats:italic>.<\/jats:italic>\n                      In this study, feasibility was defined as the ability to distinguish between a positive and negative surgical margin, imaging within 45\u00a0min and low radiation exposure to staff.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Six patients were included in this ongoing study. Following perioperative i.v. injection of ~\u2009100\u00a0MBq\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA, the prostate was excised and immediately imaged ex vivo. Different acquisition protocols were tested, and hotspots on CLI images from the intact prostate were marked for comparison with histopathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By using an acquisition protocol with 150\u00a0s exposure time, 8\u2009\u00d7\u20098 binning and a 550\u00a0nm shortpass filter, PSMs and negative surgical margins (NSMs) were visually correctly identified on CLI in 3 of the 5 patients. Two patients had a hotspot on CLI from cancer &lt;\u20090.1\u00a0mm from the excision margin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Overall, the study showed that\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA CLI is a feasible and low-risk technique for intraoperative margin assessment in PCa. The remaining patients in this ongoing study will be used to assess the diagnostic accuracy of the technique.\n                    <\/jats:p>\n                    <jats:p>Trial registration: NL8256 registered at www.trialregister.nl\u00a0on 04\/11\/20109.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-020-04783-1","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T05:45:06Z","timestamp":1585892706000},"page":"2624-2632","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["68Ga-PSMA Cerenkov luminescence imaging in primary prostate cancer: first-in-man series"],"prefix":"10.1007","volume":"47","author":[{"given":"Judith","family":"olde Heuvel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berlinda J.","family":"de Wit-van der Veen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk G.","family":"van der Poel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise M.","family":"Bekers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten R.","family":"Grootendorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal N.","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis H.","family":"Slump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel P. 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