{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:50:37Z","timestamp":1790711437605,"version":"4.1.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The DMI PET\/CT is a modular silicon photomultiplier\u2013based scanner with an axial field-of-view (FOV) between 15 and 25\u00a0cm depending on ring configuration (3, 4, or 5 rings). A new generation of the system includes a reengineered detector module, featuring improved electronics and an additional 6th ring, extending the axial FOV to 30\u00a0cm. We report on the performance evaluation of the 6-ring upgraded Generation 2 (Gen2) system while values are also reported for the 5-ring configuration of the very same system prior to the upgrade.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>PET performance was evaluated using the NEMA NU 2\u20132018 standard for spatial resolution, sensitivity, image quality, count rate performance, timing resolution, and image co-registration accuracy. Patient images were used to assess image quality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The average system sensitivity was measured at 32.76 cps\/kBq (~\u200947% increase to 5 rings at 22.29 cps\/kBq) while noise equivalent count rate peaked at 434.3 kcps corresponding to 23.6\u00a0kBq\/mL (~\u200960% increase to Generation 1 (Gen1) and 39% to Gen2 5 rings). Contrast recovery ranged between 54.5 and 85.8% similar to 5 rings, while the 6 rings provided lower background variability (2.3\u20138.5% for 5 rings vs 1.9\u20136.8% for 6 rings) and lower lung error (4.0% for the 5 rings and 3.16% for the 6 rings). Transverse\/axial full width at half-maximum (FWHM) at 1\u00a0cm (3.79\/4.26\u00a0mm) and 10\u00a0cm (4.29\/4.55\u00a0mm), scatter fraction (40.2%), energy resolution (9.63%), and time-of-flight (TOF) resolution (389.6\u00a0ps at 0\u00a0kBq\/mL) were in line to previously reported values measured across different system configurations. Improved patient image quality is obtained with the 6 rings compared to the 5 rings, while image quality is retained even at reduced scan times, enabling WB dynamic acquisitions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The higher sensitivity of the 6-ring DMI compared to the 5-ring configuration may lead to improved image quality of clinical images at reduced scan time. Additionally, it could equally be used to allow improved temporal sampling and\/or reduced overall scan time in dynamic acquisitions. Conversely, temporal sampling and scan time could be traded per application to further drive injected dose at lower levels.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00259-022-05751-7","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T04:12:31Z","timestamp":1647231151000},"page":"3023-3032","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["NEMA NU 2\u20132018 performance evaluation of a new generation 30-cm axial field-of-view Discovery MI PET\/CT"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-7533","authenticated-orcid":false,"given":"Konstantinos G.","family":"Zeimpekis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis A.","family":"Kotasidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-3292","authenticated-orcid":false,"given":"Martin","family":"Huellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nemirovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-5210","authenticated-orcid":false,"given":"Philipp A.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-3031","authenticated-orcid":false,"given":"Valerie","family":"Treyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"5751_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s00259-017-3727-z","volume":"44","author":"CS van der Vos","year":"2017","unstructured":"van der Vos CS, Koopman D, Rijnsdorp S, Arends AJ, Boellaard R, van Dalen JA, et al. Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET. Eur J Nucl Med Mol Imaging. 2017;44:4\u201316. https:\/\/doi.org\/10.1007\/s00259-017-3727-z.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"5751_CR2","doi-asserted-by":"publisher","first-page":"e0178936","DOI":"10.1371\/journal.pone.0178936","volume":"12","author":"L Baratto","year":"2017","unstructured":"Baratto L, Park SY, Hatami N, Davidzon G, Srinivas S, Gambhir SS, et al. 18F-FDG silicon photomultiplier PET\/CT: a pilot study comparing semi-quantitative measurements with standard PET\/CT. PLoS ONE. 2017;12:e0178936. https:\/\/doi.org\/10.1371\/journal.pone.0178936.","journal-title":"PLoS ONE"},{"key":"5751_CR3","unstructured":"NEMA standards publication NU 2-2018: performance measurements of positron emission tomographs (PET). Rosslyn: National Electrical Manufacturers Association; 2018. pp. 41."},{"key":"5751_CR4","unstructured":"NEMA standards publication NU 2-2012: performance measurements of positron emission tomographs (PET). Rosslyn: National Electrical Manufacturers Association; 2013."},{"key":"5751_CR5","unstructured":"Ordinance of the Federal Department of Justice and Police (FDJP) of 7. December 2012 about measuring equipment for ionizing radiation (StMmV). Swiss Federal Institute of Metrology METAS; 2012."},{"key":"5751_CR6","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.2967\/jnumed.117.189514","volume":"58","author":"DFC Hsu","year":"2017","unstructured":"Hsu DFC, Ilan E, Peterson WT, Uribe J, Lubberink M, Levin CS. Studies of a next-generation silicon-photomultiplier-based time-of-flight PET\/CT system. 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A. Kotasidis and Alexandra Nemirovsky are full-time employees of GE Healthcare, Chicago, IL, USA. The other authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}