{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:11:40Z","timestamp":1792782700248,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004635","name":"Fru Berta Kamprads Stiftelse","doi-asserted-by":"publisher","award":["FBKS-2019-44-270"],"award-info":[{"award-number":["FBKS-2019-44-270"]}],"id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004635","name":"Fru Berta Kamprads Stiftelse","doi-asserted-by":"publisher","award":["2020-8-270"],"award-info":[{"award-number":["2020-8-270"]}],"id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004635","name":"Fru Berta Kamprads Stiftelse","doi-asserted-by":"publisher","award":["2020-8-270"],"award-info":[{"award-number":["2020-8-270"]}],"id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2018\/577"],"award-info":[{"award-number":["CAN 2018\/577"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["2015\/266"],"award-info":[{"award-number":["2015\/266"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["2018\/747"],"award-info":[{"award-number":["2018\/747"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007230","name":"Stiftelsen Konung Gustaf V:s Jubileumsfond","doi-asserted-by":"publisher","award":["2020\/309"],"award-info":[{"award-number":["2020\/309"]}],"id":[{"id":"10.13039\/501100007230","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The ALF agreement","award":["ALFGBG-723481"],"award-info":[{"award-number":["ALFGBG-723481"]}]},{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Radionuclide therapy with\n                      <jats:sup>177<\/jats:sup>\n                      Lu-DOTATATE is well established for patients with advanced somatostatin receptor\u2013positive neuroendocrine tumors with a standard schedule of 7.4\u00a0GBq at four occasions. However, this approach does not consider individual variability affecting the tumor radiation dose or dose to organs at risk. Therefore, it is important to assess more personalized strategies. The aim of this phase II trial was to evaluate individualized\n                      <jats:sup>177<\/jats:sup>\n                      Lu-DOTATATE for which the number of cycles varied based on renal dosimetry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were eligible if they had a progressive, somatostatin receptor\u2013positive neuroendocrine tumor with a Ki 67 labeling index\u2009&lt;\u200920%. They received cycles of 7.4\u00a0GBq of\n                      <jats:sup>177<\/jats:sup>\n                      Lu-DOTATATE at 10\u2009\u00b1\u20092-week intervals until a predefined radiation dose to the kidneys was reached. The primary endpoint was objective tumor response (RECIST v 1.1). Secondary endpoints included progression-free survival (PFS), overall survival (OS), and toxicity (CTCAE v. 4.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-six patients who had received a median of 5 cycles (range 1\u20139) were evaluable for efficacy. The objective tumor response was 16% partial response, 66% stable disease, and 19% progressive disease. The median PFS and OS were 29\u00a0months and 47\u00a0months, respectively, and were significantly associated with kidney dose, performance status, and Ki 67 levels but not with tumor origin. The overall toxicity was mild, and the most common events were grade 1\u20132 anemia, thrombocytopenia, fatigue, nausea, and diarrhea. Grade 3\u20134 toxicity occurred in\u2009&lt;\u200910% of patients and was mostly hematological, with no grade 3\u20134 renal toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Individualized treatment with\n                      <jats:sup>177<\/jats:sup>\n                      Lu-DOTATATE based on renal dosimetry is clearly feasible with low toxicity and promising efficacy, showing the potential to further improve outcome beyond the standard approach, and should be further assessed in randomized trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      EudraCT 2011\u2013000,240-16. NCT01456078.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01456078\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01456078<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-022-05786-w","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T01:06:18Z","timestamp":1650589578000},"page":"3830-3840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Phase II trial demonstrates the efficacy and safety of individualized, dosimetry-based 177Lu-DOTATATE treatment of NET patients"],"prefix":"10.1007","volume":"49","author":[{"given":"Anna","family":"Sundl\u00f6v","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina Sj\u00f6green","family":"Gleisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tennvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ljungberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Fredrik","family":"Warfvinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajsa","family":"Holgersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hallqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-7719","authenticated-orcid":false,"given":"Johanna","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"issue":"7","key":"5786_CR1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.annonc.2020.03.304","volume":"31","author":"M Pavel","year":"2020","unstructured":"Pavel M, Oberg K, Falconi M, Krenning EP, Sundin A, Perren A, et al. Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(7):844\u201360.","journal-title":"Ann Oncol"},{"issue":"2","key":"5786_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000443168","volume":"103","author":"G DelleFave","year":"2016","unstructured":"DelleFave G, O\u2019Toole D, Sundin A, Taal B, Ferolla P, Ramage JK, et al. ENETS Consensus Guidelines update for gastroduodenal neuroendocrine neoplasms. Neuroendocrinology. 2016;103(2):119\u201324.","journal-title":"Neuroendocrinology"},{"issue":"2","key":"5786_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2967\/jnumed.119.240911","volume":"61","author":"TA Hope","year":"2020","unstructured":"Hope TA, Bodei L, Chan JA, El-Haddad G, Fidelman N, Kunz PL, et al. NANETS\/SNMMI consensus statement on patient selection and appropriate use of (177)Lu-DOTATATE peptide receptor radionuclide therapy. J Nucl Med. 2020;61(2):222\u20137.","journal-title":"J Nucl Med"},{"issue":"16","key":"5786_CR4","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.1158\/1078-0432.CCR-16-2743","volume":"23","author":"T Brabander","year":"2017","unstructured":"Brabander T, van der Zwan WA, Teunissen JJM, Kam BLR, Feelders RA, de Herder WW, et al. Long-term efficacy, survival, and safety of [(177)Lu-DOTA(0), Tyr(3)]octreotate in patients with gastroenteropancreatic and bronchial neuroendocrine tumors. Clin Cancer Res. 2017;23(16):4617\u201324.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"5786_CR5","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1007\/s00432-020-03181-2","volume":"146","author":"J Zhang","year":"2020","unstructured":"Zhang J, Song Q, Cai L, Xie Y, Chen Y. The efficacy of (177)Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours: a systematic review and meta-analysis. J Cancer Res Clin Oncol. 2020;146(6):1533\u201343.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"5786_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1056\/NEJMoa1607427","volume":"376","author":"J Strosberg","year":"2017","unstructured":"Strosberg J, El-Haddad G, Wolin E, Hendifar A, Yao J, Chasen B, et al. Phase 3 trial of (177)Lu-DOTATATE for midgut neuroendocrine tumors. N Engl J Med. 2017;376(2):125\u201335.","journal-title":"N Engl J Med"},{"issue":"1","key":"5786_CR7","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40658-017-0194-3","volume":"4","author":"C Stokke","year":"2017","unstructured":"Stokke C, Gabina PM, Solny P, Cicone F, Sandstrom M, Gleisner KS, et al. Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force. EJNMMI Phys. 2017;4(1):27.","journal-title":"EJNMMI Phys"},{"issue":"4","key":"5786_CR8","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/0360-3016(94)00475-Z","volume":"32","author":"P Okunieff","year":"1995","unstructured":"Okunieff P, Morgan D, Niemierko A, Suit HD. Radiation dose-response of human tumors. Int J Radiat Oncol Biol Phys. 1995;32(4):1227\u201337.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"5786_CR9","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1007\/s00259-014-2824-5","volume":"41","author":"L Strigari","year":"2014","unstructured":"Strigari L, Konijnenberg M, Chiesa C, Bardies M, Du Y, Gleisner KS, et al. The evidence base for the use of internal dosimetry in the clinical practice of molecular radiotherapy. Eur J Nucl Med Mol Imag. 2014;41(10):1976\u201388.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"13","key":"5786_CR10","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1007\/s00259-018-4044-x","volume":"45","author":"M Cremonesi","year":"2018","unstructured":"Cremonesi M, Ferrari ME, Bodei L, Chiesa C, Sarnelli A, Garibaldi C, et al. Correlation of dose with toxicity and tumour response to (90)Y- and (177)Lu-PRRT provides the basis for optimization through individualized treatment planning. Eur J Nucl Med Mol Imag. 2018;45(13):2426\u201341.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"11","key":"5786_CR11","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s002590050476","volume":"26","author":"A Otte","year":"1999","unstructured":"Otte A, Herrmann R, Heppeler A, Behe M, Jermann E, Powell P, et al. Yttrium-90 DOTATOC: first clinical results. Eur J Nucl Med. 1999;26(11):1439\u201347.","journal-title":"Eur J Nucl Med"},{"issue":"2","key":"5786_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00259-002-1023-y","volume":"30","author":"L Bodei","year":"2003","unstructured":"Bodei L, Cremonesi M, Zoboli S, Grana C, Bartolomei M, Rocca P, et al. Receptor-mediated radionuclide therapy with 90Y-DOTATOC in association with amino acid infusion: a phase I study. Eur J Nucl Med Mol Imag. 2003;30(2):207\u201316.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"2","key":"5786_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2967\/jnumed.114.148437","volume":"56","author":"E Ilan","year":"2015","unstructured":"Ilan E, Sandstrom M, Wassberg C, Sundin A, Garske-Roman U, Eriksson B, et al. Dose response of pancreatic neuroendocrine tumors treated with peptide receptor radionuclide therapy using 177Lu-DOTATATE. J Nucl Med. 2015;56(2):177\u201382.","journal-title":"J Nucl Med"},{"issue":"7\u20138","key":"5786_CR14","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1159\/000504001","volume":"110","author":"U Jahn","year":"2020","unstructured":"Jahn U, Ilan E, Sandstrom M, Garske-Roman U, Lubberink M, Sundin A. 177Lu-DOTATATE peptide receptor radionuclide therapy: dose response in small intestinal neuroendocrine tumors. Neuroendocrinology. 2020;110(7\u20138):662\u201370.","journal-title":"Neuroendocrinology"},{"issue":"10","key":"5786_CR15","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s00259-005-1793-0","volume":"32","author":"M Melis","year":"2005","unstructured":"Melis M, Krenning EP, Bernard BF, Barone R, Visser TJ, de Jong M. Localisation and mechanism of renal retention of radiolabelled somatostatin analogues. Eur J Nucl Med Mol Imag. 2005;32(10):1136\u201343.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"1","key":"5786_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00259-002-0982-3","volume":"30","author":"EJ Rolleman","year":"2003","unstructured":"Rolleman EJ, Valkema R, de Jong M, Kooij PP, Krenning EP. Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine. Eur J Nucl Med Mol Imag. 2003;30(1):9\u201315.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"10","key":"5786_CR17","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1007\/s00259-008-0778-1","volume":"35","author":"L Bodei","year":"2008","unstructured":"Bodei L, Cremonesi M, Ferrari M, Pacifici M, Grana CM, Bartolomei M, et al. Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors. Eur J Nucl Med Mol Imag. 2008;35(10):1847\u201356.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"Suppl 1","key":"5786_CR18","first-page":"99S","volume":"46","author":"R Barone","year":"2005","unstructured":"Barone R, Borson-Chazot F, Valkema R, Walrand S, Chauvin F, Gogou L, et al. Patient-specific dosimetry in predicting renal toxicity with (90)Y-DOTATOC: relevance of kidney volume and dose rate in finding a dose-effect relationship. JNuclMed. 2005;46(Suppl 1):99S-106S.","journal-title":"JNuclMed"},{"issue":"Suppl 1","key":"5786_CR19","first-page":"83S","volume":"46","author":"R Valkema","year":"2005","unstructured":"Valkema R, Pauwels SA, Kvols LK, Kwekkeboom DJ, Jamar F, de Jong M, et al. Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0), Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate. J Nucl Med. 2005;46(Suppl 1):83S-91S.","journal-title":"J Nucl Med"},{"issue":"9","key":"5786_CR20","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1007\/s00259-017-3678-4","volume":"44","author":"A Sundlov","year":"2017","unstructured":"Sundlov A, Sjogreen-Gleisner K, Svensson J, Ljungberg M, Olsson T, Bernhardt P, et al. Individualised (177)Lu-DOTATATE treatment of neuroendocrine tumours based on kidney dosimetry. Eur J Nucl Med Mol Imag. 2017;44(9):1480\u20139.","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"5786_CR21","volume-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2010","unstructured":"R Development Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2010."},{"issue":"10","key":"5786_CR22","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.2967\/jnumed.118.225235","volume":"60","author":"L Hagmarker","year":"2019","unstructured":"Hagmarker L, Svensson J, Ryden T, van Essen M, Sundlov A, Gleisner KS, et al. Bone marrow absorbed doses and correlations with hematologic response during (177)Lu-DOTATATE treatments are influenced by image-based dosimetry method and presence of skeletal metastases. J Nucl Med. 2019;60(10):1406\u201313.","journal-title":"J Nucl Med"},{"issue":"4","key":"5786_CR23","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1053\/j.seminoncol.2018.08.004","volume":"45","author":"J Ramage","year":"2018","unstructured":"Ramage J, Naraev BG, Halfdanarson TR. Peptide receptor radionuclide therapy for patients with advanced pancreatic neuroendocrine tumors. Semin Oncol. 2018;45(4):246\u20138.","journal-title":"Semin Oncol"},{"issue":"6","key":"5786_CR24","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1007\/s00259-018-3945-z","volume":"45","author":"U Garske-Roman","year":"2018","unstructured":"Garske-Roman U, Sandstrom M, Fross Baron K, Lundin L, Hellman P, Welin S, et al. Prospective observational study of (177)Lu-DOTA-octreotate therapy in 200 patients with advanced metastasized neuroendocrine tumours (NETs): feasibility and impact of a dosimetry-guided study protocol on outcome and toxicity. Eur J Nucl Med Mol Imag. 2018;45(6):970\u201388.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"3","key":"5786_CR25","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/s00259-018-4209-7","volume":"46","author":"M Del Prete","year":"2019","unstructured":"Del Prete M, Buteau FA, Arsenault F, Saighi N, Bouchard LO, Beaulieu A, et al. Personalized (177)Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: initial results from the P-PRRT trial. Eur J Nucl Med Mol Imag. 2019;46(3):728\u201342.","journal-title":"Eur J Nucl Med Mol Imag"},{"issue":"1","key":"5786_CR26","first-page":"134","volume":"48","author":"M Konijnenberg","year":"2007","unstructured":"Konijnenberg M, Melis M, Valkema R, Krenning E, de Jong M. Radiation dose distribution in human kidneys by octreotides in peptide receptor radionuclide therapy. J Nucl Med. 2007;48(1):134\u201342.","journal-title":"J Nucl Med"},{"issue":"1","key":"5786_CR27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40658-018-0210-2","volume":"5","author":"A Sundlov","year":"2018","unstructured":"Sundlov A, Gustafsson J, Brolin G, Mortensen N, Hermann R, Bernhardt P, et al. Feasibility of simplifying renal dosimetry in (177)Lu peptide receptor radionuclide therapy. EJNMMI Phys. 2018;5(1):12.","journal-title":"EJNMMI Phys"},{"issue":"1","key":"5786_CR28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40658-020-00293-z","volume":"7","author":"N Freedman","year":"2020","unstructured":"Freedman N, Sandstrom M, Kuten J, Shtraus N, Ospovat I, Schlocker A, et al. Personalized radiation dosimetry for PRRT-how many scans are really required? EJNMMI Phys. 2020;7(1):26.","journal-title":"EJNMMI Phys"},{"issue":"1","key":"5786_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40658-020-0273-8","volume":"7","author":"A Chicheportiche","year":"2020","unstructured":"Chicheportiche A, Ben-Haim S, Grozinsky-Glasberg S, Oleinikov K, Meirovitz A, Gross DJ, et al. Dosimetry after peptide receptor radionuclide therapy: impact of reduced number of post-treatment studies on absorbed dose calculation and on patient management. EJNMMI Phys. 2020;7(1):5.","journal-title":"EJNMMI Phys"},{"issue":"1","key":"5786_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40658-018-0232-9","volume":"5","author":"KP Willowson","year":"2018","unstructured":"Willowson KP, Eslick E, Ryu H, Poon A, Bernard EJ, Bailey DL. Feasibility and accuracy of single time point imaging for renal dosimetry following (177)Lu-DOTATATE (\u2018Lutate\u2019) therapy. EJNMMI Phys. 2018;5(1):33.","journal-title":"EJNMMI Phys"},{"issue":"1","key":"5786_CR31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2967\/jnumed.117.193706","volume":"59","author":"H Hanscheid","year":"2017","unstructured":"Hanscheid H, Lapa C, Buck AK, Lassmann M, Werner RA. Dose mapping after endoradiotherapy with (177)Lu-DOTATATE\/DOTATOC by a single measurement after 4 days. J Nucl Med. 2017;59(1):75\u201381.","journal-title":"J Nucl Med"},{"issue":"6","key":"5786_CR32","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s00259-015-3001-1","volume":"42","author":"J Svensson","year":"2015","unstructured":"Svensson J, Berg G, Wangberg B, Larsson M, Forssell-Aronsson E, Bernhardt P. Renal function affects absorbed dose to the kidneys and haematological toxicity during (1)(7)(7)Lu-DOTATATE treatment. Eur J Nucl Med Mol Imag. 2015;42(6):947\u201355.","journal-title":"Eur J Nucl Med Mol Imag"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-022-05786-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-022-05786-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-022-05786-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T15:07:55Z","timestamp":1661267275000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00259-022-05786-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["5786"],"URL":"https:\/\/doi.org\/10.1007\/s00259-022-05786-w","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]},"assertion":[{"value":"13 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The trial was conducted in accordance with ICH GCP and the Declaration of Helsinki and was approved by the regional ethics review board (EPN Lund 2011\/287).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all participants in this trial.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agree with the submitted version of the manuscript. The material submitted for publication has not been previously reported and is not under consideration for publication elsewhere.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Anna Sundl\u00f6v declares having received speaker honoraria from Novartis, Ipsen, and Sam Nordic, advisory board fees from Advanced Accelerator Applications, and consultancy fees from Spago Nanomedical.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}