{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:53:06Z","timestamp":1790621586524,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F31 CA254223"],"award-info":[{"award-number":["F31 CA254223"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA098575"],"award-info":[{"award-number":["R01 CA098575"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA 236385"],"award-info":[{"award-number":["R01 CA 236385"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA014599"],"award-info":[{"award-number":["P30 CA014599"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB002034"],"award-info":[{"award-number":["P41 EB002034"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD025265"],"award-info":[{"award-number":["S10 OD025265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB029948"],"award-info":[{"award-number":["R01 EB029948"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00259-022-05889-4","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T04:02:49Z","timestamp":1657080169000},"page":"4014-4024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth"],"prefix":"10.1007","volume":"49","author":[{"given":"Inna","family":"Gertsenshteyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Epel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Zamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Markiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Ming","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanian","family":"Sundramoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lukens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Bhuiyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Freifelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kucharski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Giurcanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian B.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Karczmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Min","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Halpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-8726","authenticated-orcid":false,"given":"Chin-Tu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"issue":"4","key":"5889_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/jnci\/93.4.266","volume":"93","author":"M Hockel","year":"2001","unstructured":"Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 2001;93(4):266\u201376.","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"5889_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","volume":"26","author":"P Vaupel","year":"2007","unstructured":"Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007;26(2):225\u201339.","journal-title":"Cancer Metastasis Rev"},{"issue":"26","key":"5889_CR3","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1200\/JCO.2007.12.7878","volume":"25","author":"J Overgaard","year":"2007","unstructured":"Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol. 2007;25(26):4066\u201374.","journal-title":"J Clin Oncol"},{"issue":"4","key":"5889_CR4","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.ijrobp.2018.10.041","volume":"103","author":"B Epel","year":"2019","unstructured":"Epel B, Maggio MC, Barth ED, et al. Oxygen-guided radiation therapy. Int J Radiat Oncol Biol Phys. 2019;103(4):977\u201384.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"5889_CR5","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1667\/RR1926.1","volume":"172","author":"MW Dewhirst","year":"2009","unstructured":"Dewhirst MW. Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res. 2009;172(6):653\u201365.","journal-title":"Radiat Res"},{"key":"5889_CR6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2147\/HP.S93413","volume":"3","author":"B Muz","year":"2015","unstructured":"Muz B, Azab F, Azab AK. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckl). 2015;3:83\u201392.","journal-title":"Hypoxia (Auckl)"},{"key":"5889_CR7","first-page":"1217","volume":"56","author":"G Schwarz","year":"1909","unstructured":"Schwarz G. Uber Desensibilisierung gegen Rontgen- und Radiumstrahlen. Munch Med Wochenschr. 1909;56:1217\u20138.","journal-title":"Munch Med Wochenschr"},{"issue":"782","key":"5889_CR8","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1098\/rspb.1933.0044","volume":"113","author":"HG Crabtree","year":"1933","unstructured":"Crabtree HG, Cramer W. The action of radium on cancer cells II - some factors determining the susceptibility of cancer cells to radium. Proc R Soc Lond B. 1933;113(782):238\u201350.","journal-title":"Proc R Soc Lond B"},{"key":"5889_CR9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/bjc.1955.55","volume":"9","author":"RH Thomlinson","year":"1955","unstructured":"Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955;9:539\u201363.","journal-title":"Br J Cancer"},{"issue":"15","key":"5889_CR10","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1089\/ars.2017.7391","volume":"28","author":"S Kishimoto","year":"2018","unstructured":"Kishimoto S, Saito K, Enomoto A, et al. Pulsed electron paramagnetic resonance imaging: applications in the studies of tumor physiology. Antioxid Redox Signal. 2018;28(15):1378\u201393.","journal-title":"Antioxid Redox Signal"},{"key":"5889_CR11","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/978-1-4939-3023-4_45","volume":"876","author":"B Epel","year":"2016","unstructured":"Epel B, Redler G, Tormyshev V, Halpern HJ. Towards human oxygen images with electron paramagnetic resonance imaging. Adv Exp Med Biol. 2016;876:363\u20139.","journal-title":"Adv Exp Med Biol"},{"issue":"Suppl 2","key":"5889_CR12","doi-asserted-by":"publisher","first-page":"129S","DOI":"10.2967\/jnumed.107.045914","volume":"49","author":"KA Krohn","year":"2008","unstructured":"Krohn KA, Link JM, Mason RP. Molecular imaging of hypoxia. J Nucl Med. 2008;49(Suppl 2):129S-S148.","journal-title":"J Nucl Med"},{"key":"5889_CR13","first-page":"365","volume":"4","author":"E Lopci","year":"2014","unstructured":"Lopci E, Grassi I, Chiti A, et al. PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence. Am J Nucl Med Mol Imaging. 2014;4:365\u201384.","journal-title":"Am J Nucl Med Mol Imaging"},{"issue":"7","key":"5889_CR14","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.2967\/jnumed.116.188367","volume":"58","author":"P Vera","year":"2017","unstructured":"Vera P, Thureau S, Chaumet-Riffaud P, et al. Phase II Study of a radiotherapy total dose increase in hypoxic lesions identified by 18F-misonidazole PET\/CT in patients with non-small cell lung carcinoma (RTEP5 study). J Nucl Med. 2017;58(7):1045\u201353.","journal-title":"J Nucl Med"},{"issue":"6","key":"5889_CR15","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/jnci\/djaa184","volume":"113","author":"N Riaz","year":"2021","unstructured":"Riaz N, Sherman E, Pei X, et al. Precision radiotherapy: reduction in radiation for oropharyngeal cancer in the 30 ROC Trial. J Natl Cancer Inst. 2021;113(6):742\u201351.","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"5889_CR16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/bjc.2014.610","volume":"112","author":"IN Fleming","year":"2015","unstructured":"Fleming IN, Manavaki R, Blower PJ, et al. Imaging tumour hypoxia with positron emission tomography. Br J Cancer. 2015;112(2):238\u201350.","journal-title":"Br J Cancer"},{"issue":"13","key":"5889_CR17","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.3390\/cancers13133290","volume":"13","author":"G Ferini","year":"2021","unstructured":"Ferini G, Valenti V, Tripoli A, et al. Lattice or oxygen-guided radiotherapy: what if they converge? Possible future directions in the era of immunotherapy. Cancers (Basel). 2021;13(13):3290.","journal-title":"Cancers (Basel)"},{"issue":"6","key":"5889_CR18","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1080\/0284186X.2017.1293289","volume":"56","author":"E Lindblom","year":"2017","unstructured":"Lindblom E, Dasu A, Uhrdin J, et al. Defining the hypoxic target volume based on positron emission tomography for image guided radiotherapy - the influence of the choice of the reference region and conversion function. Acta Oncol. 2017;56(6):819\u201325.","journal-title":"Acta Oncol"},{"issue":"8","key":"5889_CR19","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.3109\/0284186X.2012.759273","volume":"52","author":"JH Chang","year":"2013","unstructured":"Chang JH, Wada M, Anderson NJ, et al. Hypoxia-targeted radiotherapy dose painting for head and neck cancer using (18)F-FMISO PET: a biological modeling study. Acta Oncol. 2013;52(8):1723\u20139.","journal-title":"Acta Oncol"},{"issue":"3","key":"5889_CR20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00066-014-0752-8","volume":"191","author":"HB de Figueiredo","year":"2015","unstructured":"de Figueiredo HB, Zacharatou C, Galland-Girodet S, et al. Hypoxia imaging with [18F]-FMISO-PET for guided dose escalation with intensity-modulated radiotherapy in head-and-neck cancers. Strahlenther Onkol. 2015;191(3):217\u201324.","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"5889_CR21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.radonc.2011.07.029","volume":"101","author":"K Hendrickson","year":"2011","unstructured":"Hendrickson K, Phillips M, Smith W, Peterson L, Krohn K, Rajendran J. Hypoxia imaging with [F-18] FMISO-PET in head and neck cancer: potential for guiding intensity modulated radiation therapy in overcoming hypoxia-induced treatment resistance. Radiother Oncol. 2011;101(3):369\u201375.","journal-title":"Radiother Oncol"},{"issue":"6","key":"5889_CR22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nrc2397","volume":"8","author":"MW Dewhirst","year":"2008","unstructured":"Dewhirst MW, Cao YT, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer. 2008;8(6):425\u201337.","journal-title":"Nat Rev Cancer"},{"key":"5889_CR23","doi-asserted-by":"publisher","unstructured":"Kim H, Epel B, Sundramoorthy S, et al. Development of a PET\/EPRI combined imaging system for assessing tumor hypoxia. J Instrum. 2021;16(P03031). https:\/\/doi.org\/10.1088\/1748-0221\/16\/03\/p03031.","DOI":"10.1088\/1748-0221\/16\/03\/p03031"},{"issue":"2","key":"5889_CR24","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.ijrobp.2008.02.022","volume":"71","author":"M Elas","year":"2008","unstructured":"Elas M, Bell R, Hleihel D, et al. Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas. Int J Radiat Oncol Biol Phys. 2008;71(2):542\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"5889_CR25","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/0969-8043(93)90110-V","volume":"44","author":"JL Lim","year":"1993","unstructured":"Lim JL, Berridge MS. An efficient radiosynthesis of [18F]fluoromisonidazole. Appl Radiat Isot. 1993;44(8):1085\u201391.","journal-title":"Appl Radiat Isot"},{"issue":"2","key":"5889_CR26","doi-asserted-by":"publisher","first-page":"e200104","DOI":"10.1148\/rycan.2021200104","volume":"3","author":"I Gertsenshteyn","year":"2021","unstructured":"Gertsenshteyn I, Epel B, Barth E, et al. improving tumor hypoxia location in 18F-misonidazole PET with dynamic contrast-enhanced MRI using quantitative electron paramagnetic resonance partial oxygen pressure images. Radiol Imaging Cancer. 2021;3(2):e200104. https:\/\/doi.org\/10.1148\/rycan.2021200104.","journal-title":"Radiol Imaging Cancer."},{"key":"5889_CR27","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","volume":"10","author":"PS Tofts","year":"1999","unstructured":"Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10:223\u201332.","journal-title":"J Magn Reson Imaging"},{"issue":"10","key":"5889_CR28","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00723-021-01381-8","volume":"52","author":"B Epel","year":"2021","unstructured":"Epel B, Halpern HJ. EPR oxygen imaging workflow with MATLAB Image Registration Toolbox. Appl Magn Reson. 2021;52(10):1311\u20139.","journal-title":"Appl Magn Reson"},{"issue":"6","key":"5889_CR29","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1113\/JP278816","volume":"599","author":"I Gertsenshteyn","year":"2021","unstructured":"Gertsenshteyn I, Giurcanu M, Vaupel P, Halpern H. Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue. J Physiol. 2021;599(6):1759\u201367.","journal-title":"J Physiol"},{"issue":"4","key":"5889_CR30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0001-2998(78)80014-2","volume":"8","author":"CE Metz","year":"1978","unstructured":"Metz CE. Basic principles of ROC analysis. Semin Nucl Med. 1978;8(4):283\u201398.","journal-title":"Semin Nucl Med"},{"issue":"7","key":"5889_CR31","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.2967\/jnumed.116.188649","volume":"58","author":"M Grkovski","year":"2017","unstructured":"Grkovski M, Sch\u00f6der H, Lee N, et al. multiparametric imaging of tumor hypoxia and perfusion with 18F-fluoromisonidazole dynamic PET in head and neck cancer. J Nucl Med. 2017;58(7):1072\u201380.","journal-title":"J Nucl Med"},{"issue":"10","key":"5889_CR32","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1088\/0031-9155\/50\/10\/002","volume":"50","author":"D Thorwarth","year":"2005","unstructured":"Thorwarth D, Eschmann SM, Paulsen F, Alber M. A kinetic model for 18F-Fmiso PET data to analyse tumour hypoxia. Phys Med Biol. 2005;50(10):2209\u201324.","journal-title":"Phys Med Biol"},{"key":"5889_CR33","doi-asserted-by":"publisher","unstructured":"Horsman MR, Vaupel P. Pathophysiological basis for the formation of the tumor microenvironment. Front Oncol. 2016;6(66). https:\/\/doi.org\/10.3389\/fonc.2016.00066.","DOI":"10.3389\/fonc.2016.00066"},{"issue":"12","key":"5889_CR34","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1177\/1947601911423654","volume":"2","author":"B Krock","year":"2011","unstructured":"Krock B, Skuli N, Simon CM. Hypoxia-induced angiogenesis: good and evil. Genes Cancer. 2011;2(12):1117\u201333.","journal-title":"Genes Cancer"},{"issue":"12","key":"5889_CR35","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1053\/jpsu.2000.19241","volume":"35","author":"J Karth","year":"2000","unstructured":"Karth J, Ferrer FA, Perman E, et al. Coexpression of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in Wilms\u2019 tumor. J Pediatr Surg. 2000;35(12):1749\u201353.","journal-title":"J Pediatr Surg"},{"issue":"6","key":"5889_CR36","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1002\/mp.12228","volume":"44","author":"U Simoncic","year":"2017","unstructured":"Simoncic U, Leibfarth S, Welz S, et al. Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients. Med phys. 2017;44(6):2358\u201368.","journal-title":"Med phys"},{"issue":"1","key":"5889_CR37","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00330-020-07067-2","volume":"31","author":"JC Carmona-Bozo","year":"2021","unstructured":"Carmona-Bozo JC, Manavaki R, Woitek R, et al. Hypoxia and perfusion in breast cancer: simultaneous assessment using PET\/MR imaging. Eur Radiol. 2021;31(1):333\u201344.","journal-title":"Eur Radiol"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-022-05889-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-022-05889-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-022-05889-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T17:10:11Z","timestamp":1664557811000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00259-022-05889-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["5889"],"URL":"https:\/\/doi.org\/10.1007\/s00259-022-05889-4","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"3 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Author Chin-Tu Chen (CTC) is a PI for the following grants from NIH\/NIBIB (R01 EB022388 and R01 EB029948), NIH\/NIDA (R01 DA044760), and NIH\/NCI (P30 CA14599 facility). CTC receives a personal fee from the American Institute of Physics for editorial responsibilities. Other relationships include institute licenses patents (CTC is a co-inventor) to RefleXion Medical, Inc. and Incom. CTC is a co-founder and on the board of directors of EVO Worldwide LLC and AEPX Imaging, Inc. Author Howard Halpern (HH) is a PI for the following grants from NIH\/NCI (R01 CA098575 and P30 CA014599) and NIH\/NIBIB (P41 EB002034). HH also holds two US patents (8,664,955 and 9,392,957) to him and one (9,392,957) to author Boris Epel (BE) for aspects of the pO<sub>2<\/sub> imaging technology; HH and BE are also members of a start-up company O2M to market the pO<sub>2<\/sub> imaging technology in preclinical models. No other potential conflicts of interest relevant to this article exist. The rest of the authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}