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Due to the short half-life of carbon-11 and a high non-specific liver uptake of [<jats:sup>11<\/jats:sup>C]metomidate there is a need for improved adrenal imaging methods. In a previous pre-clinical study <jats:italic>para<\/jats:italic>-chloro-2-[<jats:sup>18<\/jats:sup>F]fluoroethyletomidate has been proven to be a specific adrenal tracer. The objective is to perform a first evaluation of <jats:italic>para<\/jats:italic>-chloro-2-[<jats:sup>18<\/jats:sup>F]fluoroethyletomidate positron emission computed tomography ([<jats:sup>18<\/jats:sup>F]CETO-PET\/CT) in patients with adrenal tumours and healthy volunteers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifteen patients underwent [<jats:sup>18<\/jats:sup>F]CETO-PET\/CT. Five healthy volunteers were recruited for test-retest analysis and three out of the five underwent additional [<jats:sup>15<\/jats:sup>O]water PET\/CT to measure adrenal blood flow. Arterial blood sampling and tracer metabolite analysis was performed. The kinetics of [<jats:sup>18<\/jats:sup>F]CETO were assessed and simplified quantitative methods were validated by comparison to outcome measures of tracer kinetic analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Uptake of [<jats:sup>18<\/jats:sup>F]CETO was low in the liver and high in adrenals. Initial metabolization was rapid, followed by a plateau. The kinetics of [<jats:sup>18<\/jats:sup>F]CETO in healthy adrenals and all adrenal pathologies, except for adrenocortical carcinoma, were best described by an irreversible single-tissue compartment model. Standardized uptake values (SUV) correlated well with the uptake rate constant <jats:italic>K<\/jats:italic><jats:sub>1<\/jats:sub>. Both <jats:italic>K<\/jats:italic><jats:sub>1<\/jats:sub> and SUV were highly correlated to adrenal blood flow in healthy controls. Repeatability coefficients of <jats:italic>K<\/jats:italic><jats:sub>1<\/jats:sub>, SUV<jats:sub>65\u201370<\/jats:sub>, and SUV<jats:sub>120<\/jats:sub> were 25, 22, and 17%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>High adrenal uptake combined with a low unspecific liver uptake suggests that <jats:sup>18<\/jats:sup>F]CETO is a suitable tracer for adrenal imaging. Adrenal SUV, based on a whole-body scan at 1 h p.i., correlated well with the net uptake rate <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, NCT05361083 Retrospectively registered 29 April 2022. at,\u00a0<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05361083\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05361083<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00259-022-05957-9","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T08:54:24Z","timestamp":1662627264000},"page":"398-409","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-0974","authenticated-orcid":false,"given":"Isabella","family":"Silins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Sundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lubberink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lleah","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gurnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Aigbirhio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Roslin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Antoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"5957_CR1","first-page":"982","volume":"39","author":"M Bergstr\u00f6m","year":"1998","unstructured":"Bergstr\u00f6m M, Juhlin C, Bonasera TA, Sundin A, Rastad J, \u00c5kerstr\u00f6m G, et al. 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