{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:49:09Z","timestamp":1792756149063,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To relate [<jats:sup>18<\/jats:sup>F]fluoride uptake on PET with abnormalities on magnetic resonance imaging (MRI) and conventional radiography (CR) in ankylosing spondylitis (AS) patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ten clinically active AS patients (female 6\/10, age 38 \u00b1 11 years) were included, and both spine and SI-joints were examined. PET scans were dichotomously scored for enhanced [<jats:sup>18<\/jats:sup>F]fluoride uptake, MRI scans were scored for fatty lesions, erosions, ankylosis, and bone marrow edema (BME), and CR was scored for erosions, syndesmophytes, and ankylosis. The overlap of lesions across all modalities was evaluated through univariate and multivariate analyses using a generalized mixed model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the spine, 69 lesions with enhanced [<jats:sup>18<\/jats:sup>F]fluoride uptake, 257 MRI lesions, and 88 CR lesions were observed. PET lesions were mostly located in costovertebral and facet joints, outside the field of view (FOV) of the MRI and CR. However, PET lesions inside the FOV of MRI and CR partially showed no abnormality on MRI and CR. In lesions with abnormalities on multiple modalities, both univariate and multivariate analysis showed that PET activity had the strongest association with BME on MRI and ankylosis on CR. In the SI joints, 15 lesions (75%) with PET uptake were found, with 87% showing abnormalities on MRI and CR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>[<jats:sup>18<\/jats:sup>F]fluoride PET lesions are often found outside the scope of MRI and CR, and even in the same location show only partial overlap with abnormalities on MRI (especially BME) and CR (especially ankylosis). This suggests that [<jats:sup>18<\/jats:sup>F]fluoride PET partially visualizes aspects of AS separate from MRI and CR, providing novel information.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registration<\/jats:title>\n                <jats:p>NL43223.029.13 registered at 02-05-2013.\u00a0<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.toetsingonline.nl\/to\/ccmo_search.nsf\/fABRpop?readform&amp;unids=C1257BA2002CC066C1257B4E0049A65A\">https:\/\/www.toetsingonline.nl\/to\/ccmo_search.nsf\/fABRpop?readform&amp;unids=C1257BA2002CC066C1257B4E0049A65A<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00259-022-06080-5","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T11:02:59Z","timestamp":1670842979000},"page":"1351-1359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["[18F]Fluoride PET provides distinct information\u00a0on disease activity in ankylosing spondylitis as compared to MRI and conventional radiography"],"prefix":"10.1007","volume":"50","author":[{"given":"Jerney","family":"de Jongh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicki J. 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H.","family":"Boden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F.","family":"Smithuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem F.","family":"Lems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Lammertsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre E.","family":"Voskuyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Boers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben J. 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Approval was granted by the Ethics Committee of the VU University Medical Center (2013\/38).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients gave written informed consent to participate in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"J.d.J., N.J.F.V., M.Y., C.J.v.D. J.C.J.B., B.J.H.B., R.H., F.F.S., A.A.L., A.E.V., M.B., G.J.C.Z., C.J.v.d.L.: no competing interests to declare.I.E.v.d.H.B: consultant for AbbVie, UCB, MSD, Novartis, Lilly; unrestricted grants received for investigator-initiated studies from MSD, Pfizer, AbbVie, UCB; fees received for Lectures from BMS, AbbVie, Pfizer, MSD, UCB. W.F.L.: speaker fees\/advisory boards for Pfizer. Amgen, UCB, Galapagos.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}