{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:29:13Z","timestamp":1790508553126,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00259-023-06156-w","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T07:03:34Z","timestamp":1677827014000},"page":"2047-2055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regional brain glucose metabolism is differentially affected by ketogenic diet: a human semiquantitative positron emission tomography"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-309X","authenticated-orcid":false,"given":"Tatiana","family":"Horowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Doche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Cammilleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Suissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Guedj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"6156_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1146\/annurev.me.24.020173.001415","volume":"24","author":"L Sokoloff","year":"1973","unstructured":"Sokoloff L. Metabolism of ketone bodies by the brain. Annu Rev Med. 1973;24:271\u201380.","journal-title":"Annu Rev Med"},{"issue":"4","key":"6156_CR2","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","volume":"86","author":"PJ Magistretti","year":"2015","unstructured":"Magistretti PJ, Allaman I. A cellular perspective on brain energy metabolism and functional imaging. Neuron. 2015;86(4):883\u2013901.","journal-title":"Neuron"},{"issue":"8","key":"6156_CR3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/ejcn.2013.116","volume":"67","author":"A Paoli","year":"2013","unstructured":"Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr. 2013;67(8):789\u201396.","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"6156_CR4","doi-asserted-by":"publisher","first-page":"E524","DOI":"10.3390\/ijms22020524","volume":"22","author":"L Suissa","year":"2021","unstructured":"Suissa L, Kotchetkov P, Guigonis J-M, Doche E, Osman O, Pourcher T, et al. Ingested ketone ester leads to a rapid rise of acetyl-CoA and competes with glucose metabolism in the brain of non fasted mice. Int J Mol Sci. 2021;22(2):E524.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"6156_CR5","doi-asserted-by":"publisher","first-page":"W151","DOI":"10.2214\/AJR.07.2409","volume":"190","author":"G Williams","year":"2008","unstructured":"Williams G, Kolodny GM. Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet. AJR Am J Roentgenol. 2008;190(2):W151\u2013156.","journal-title":"AJR Am J Roentgenol"},{"key":"6156_CR6","doi-asserted-by":"crossref","unstructured":"Selvaraj S, Margulies K, Dugyala S, Schubert E, Tierney A, Arany Z, et al. Comparison of exogenous ketone administration versus dietary carbohydrate restriction on myocardial glucose suppression: a crossover clinical trial. J Nuc Med. 2021 Oct 1 Jan 18; Available from: https:\/\/jnm.snmjournals.org\/content\/early\/2021\/10\/21\/jnumed.121.262734.","DOI":"10.2967\/jnumed.121.262734"},{"issue":"10","key":"6156_CR7","doi-asserted-by":"publisher","first-page":"E2510","DOI":"10.3390\/nu11102510","volume":"11","author":"M U\u0142amek-Kozio\u0142","year":"2019","unstructured":"U\u0142amek-Kozio\u0142 M, Czuczwar SJ, Januszewski S, Pluta R. Ketogenic diet and epilepsy. Nutrients. 2019;11(10):E2510.","journal-title":"Nutrients"},{"issue":"1","key":"6156_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3988\/jcn.2015.11.1.26","volume":"11","author":"F Ye","year":"2015","unstructured":"Ye F, Li X-J, Jiang W-L, Sun H-B, Liu J. Efficacy of and patient compliance with a ketogenic diet in adults with intractable epilepsy: a meta-analysis. J Clin Neurol. 2015;11(1):26\u201331.","journal-title":"J Clin Neurol"},{"issue":"16","key":"6156_CR9","doi-asserted-by":"publisher","first-page":"E3892","DOI":"10.3390\/ijms20163892","volume":"20","author":"M Rusek","year":"2019","unstructured":"Rusek M, Pluta R, U\u0142amek-Kozio\u0142 M, Czuczwar SJ. Ketogenic diet in Alzheimer\u2019s disease. Int J Mol Sci. 2019;20(16):E3892.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"6156_CR10","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1212\/01.WNL.0000152046.11390.45","volume":"64","author":"TB Vanitallie","year":"2005","unstructured":"Vanitallie TB, Nonas C, Di Rocco A, Boyar K, Hyams K, Heymsfield SB. Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. Neurology. 2005;64(4):728\u201330.","journal-title":"Neurology"},{"issue":"3","key":"6156_CR11","first-page":"59","volume":"9","author":"CE Stafstrom","year":"2012","unstructured":"Stafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012;9(3):59.","journal-title":"Front Pharmacol"},{"key":"6156_CR12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.sleep.2018.12.014","volume":"55","author":"MJ Siegmann","year":"2019","unstructured":"Siegmann MJ, Athinarayanan SJ, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, et al. Improvement in patient-reported sleep in type 2 diabetes and prediabetes participants receiving a continuous care intervention with nutritional ketosis. Sleep Med. 2019;55:92\u20139.","journal-title":"Sleep Med"},{"issue":"4","key":"6156_CR13","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1001\/jama.2019.20939","volume":"323","author":"BM Kuehn","year":"2020","unstructured":"Kuehn BM. In Alzheimer research, glucose metabolism moves to center stage. JAMA. 2020;323(4):297\u20139.","journal-title":"JAMA"},{"issue":"10","key":"6156_CR14","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3389\/fneur.2019.00585","volume":"12","author":"H Yang","year":"2019","unstructured":"Yang H, Shan W, Zhu F, Wu J, Wang Q. Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms. Front Neurol. 2019;12(10):585.","journal-title":"Front Neurol"},{"issue":"3","key":"6156_CR15","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"DA Butterfield","year":"2019","unstructured":"Butterfield DA, Halliwell B. Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci. 2019;20(3):148\u201360.","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"6156_CR16","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s11910-006-0027-6","volume":"6","author":"J Huffman","year":"2006","unstructured":"Huffman J, Kossoff EH. State of the ketogenic diet(s) in epilepsy. Curr Neurol Neurosci Rep. 2006;6(4):332\u201340.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"10","key":"6156_CR17","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1172\/JCI105650","volume":"46","author":"OE Owen","year":"1967","unstructured":"Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF. Brain metabolism during fasting. J Clin Invest. 1967;46(10):1589\u201395.","journal-title":"J Clin Invest"},{"issue":"8","key":"6156_CR18","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/jcbfm.2013.87","volume":"33","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Kuang Y, Xu K, Harris D, Lee Z, LaManna J, et al. Ketosis proportionately spares glucose utilization in brain. J Cereb Blood Flow Metab. 2013;33(8):1307\u201311.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"6156_CR19","doi-asserted-by":"publisher","first-page":"E746","DOI":"10.1152\/ajpendo.1996.270.5.E746","volume":"270","author":"SG Hasselbalch","year":"1996","unstructured":"Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, et al. Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. American Journal of Physiology-Endocrinology and Metabolism. 1996;270(5):E746\u201351.","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"issue":"7","key":"6156_CR20","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1177\/0271678X16669366","volume":"37","author":"A Courchesne-Loyer","year":"2017","unstructured":"Courchesne-Loyer A, Croteau E, Castellano C-A, St-Pierre V, Hennebelle M, Cunnane SC. Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: a dual tracer quantitative positron emission tomography study. J Cereb Blood Flow Metab. 2017;37(7):2485\u201393.","journal-title":"J Cereb Blood Flow Metab"},{"key":"6156_CR21","doi-asserted-by":"publisher","first-page":"733607","DOI":"10.3389\/fncel.2021.733607","volume":"15","author":"D Li\u015bkiewicz","year":"2021","unstructured":"Li\u015bkiewicz D, Li\u015bkiewicz A, Nowacka-Chmielewska MM, Grabowski M, Pondel N, Grabowska K, et al. Differential response of hippocampal and cerebrocortical autophagy and ketone body metabolism to the ketogenic diet. Front Cell Neurosci. 2021;15:733607.","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"6156_CR22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/RLU.0b013e31827082c4","volume":"38","author":"K Korsholm","year":"2013","unstructured":"Korsholm K, Law I. Effects of a ketogenic diet on brain metabolism in epilepsy. Clin Nucl Med. 2013;38(1):38\u20139.","journal-title":"Clin Nucl Med"},{"key":"6156_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s41824-022-00150-5","volume":"6","author":"OA Bennett","year":"2022","unstructured":"Bennett OA, Ramsay SC, Malacova E, et al. Regional differences in the reduction in cerebral FDG uptake induced by the ketogenic diet. European J Hybrid Imaging. 2022;6:29. https:\/\/doi.org\/10.1186\/s41824-022-00150-5.","journal-title":"European J Hybrid Imaging"},{"issue":"2","key":"6156_CR24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.pscychresns.2007.11.004","volume":"164","author":"I Yakushev","year":"2008","unstructured":"Yakushev I, Landvogt C, Buchholz H-G, Fellgiebel A, Hammers A, Scheurich A, et al. Choice of reference area in studies of Alzheimer\u2019s disease using positron emission tomography with fluorodeoxyglucose-F18. Psychiatry Research: Neuroimaging. 2008;164(2):143\u201353.","journal-title":"Psychiatry Research: Neuroimaging"},{"issue":"3","key":"6156_CR25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.neurobiolaging.2008.05.001","volume":"31","author":"A Caroli","year":"2010","unstructured":"Caroli A, Geroldi C, Nobili F, et al. Functional compensation in incipient Alzheimer\u2019s disease. Neurobiol Aging. 2010;31(3):387\u201397. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2008.05.001.","journal-title":"Neurobiol Aging"},{"issue":"6","key":"6156_CR26","doi-asserted-by":"publisher","first-page":"894","DOI":"10.2967\/jnumed.112.113928","volume":"54","author":"S Morbelli","year":"2013","unstructured":"Morbelli S, Perneczky R, Drzezga A, et al. Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project. J Nucl Med. 2013;54(6):894\u2013902. https:\/\/doi.org\/10.2967\/jnumed.112.113928.","journal-title":"J Nucl Med"},{"issue":"7","key":"6156_CR27","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00259-009-1060-x","volume":"36","author":"E Guedj","year":"2009","unstructured":"Guedj E, Barbeau EJ, Didic M, Felician O, de Laforte C, Ranjeva J-P, et al. Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation? Eur J Nucl Med Mol Imaging. 2009;36(7):1101\u201312.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"6156_CR28","doi-asserted-by":"publisher","unstructured":"Dienel GA, Gillinder L, McGonigal A, Borges K. Potential new roles for glycogen in epilepsy [published online ahead of print, 2022 Sep 19]. Epilepsia. 2022;https:\/\/doi.org\/10.1111\/epi.17412. https:\/\/doi.org\/10.1111\/epi.17412","DOI":"10.1111\/epi.17412 10.1111\/epi.17412"},{"issue":"6","key":"6156_CR29","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.neurobiolaging.2013.11.027","volume":"35","author":"S Nugent","year":"2014","unstructured":"Nugent S, Tremblay S, Chen KW, et al. Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiol Aging. 2014;35(6):1386\u201395. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2013.11.027.","journal-title":"Neurobiol Aging"},{"issue":"21","key":"6156_CR30","first-page":"00068","volume":"S1875\u20132136","author":"F Arregle","year":"2021","unstructured":"Arregle F, Martel H, Philip M, Gouriet F, Casalta JP, Riberi A, et al. Infective endocarditis with neurological complications: delaying cardiac surgery is associated with worse outcome. Arch Cardiovasc Dis. 2021;S1875\u20132136(21):00068\u201371.","journal-title":"Arch Cardiovasc Dis"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-023-06156-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-023-06156-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-023-06156-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T04:05:28Z","timestamp":1684555528000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00259-023-06156-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["6156"],"URL":"https:\/\/doi.org\/10.1007\/s00259-023-06156-w","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]},"assertion":[{"value":"15 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The retrospective observations required no ethical approval requirement other than informed consent. The local PET database of healthy controls was acquired in accordance with the Declaration of Helsinki, with informed written consent from the patients and approval from the \u201cCPP Sud M\u00e9diterran\u00e9e V\u201d ethics committee. Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}