{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:39:15Z","timestamp":1784637555689,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Lymph node (LN) metastasis is a relevant predictor for survival in patients with a.o. penile cancer (PeCa), malignant melanoma. The sentinel node (SN) procedure comprises targeted resection of the first tumour-draining SNs. Here, the hybrid tracer indocyanine green (ICG)-<jats:sup>99m<\/jats:sup>Tc-nanocolloid has been used for several years to combine optical and nuclear detection. Recently, the resource of the nanocolloid precursor stopped production and the precursor was replaced by a different but chemically comparable colloid, nanoscan. Our aim was to study the performance of ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan compared to ICG-<jats:sup>99m<\/jats:sup>Tc-nanocolloid from a nuclear and surgical perspective.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-four patients with either PeCa or head-and-neck (H&amp;N) melanoma and scheduled for a SN procedure were included. The initial group (<jats:italic>n<\/jats:italic> = 11) received ICG-<jats:sup>99m<\/jats:sup>Tc-nanocolloid until no longer available; the second group (<jats:italic>n<\/jats:italic> = 13) received ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan. Tracer uptake was assessed on lymphoscintigraphy and single-photon emission (SPECT). Intraoperatively, SNs were identified using gamma tracing and fluorescence imaging. Ex vivo (back-table) measurements were conducted to quantify the fluorescence emissions. Chemical analysis was performed to compare the ICG assembly on both precursors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean tracer uptake in the SNs was similar for ICG-<jats:sup>99m<\/jats:sup>Tc-nanocolloid (2.2 \u00b1 4.3%ID) and ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan (1.8 \u00b1 2.6%ID; <jats:italic>p<\/jats:italic> = 0.68). 3 SNs (interquartile range (IQR) 3\u20134) were detected on lymphoscintigraphy in PeCa patients receiving ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan compared to 2 SNs (IQR 2\u20133) in PeCa patients receiving ICG-<jats:sup>99m<\/jats:sup>Tc-nanocolloid (<jats:italic>p<\/jats:italic> = 0.045), no differences were observed in H&amp;N patients. Back-table measurements of resected SNs revealed a lower total fluorescence intensity in the ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan group (24*10<jats:sup>9<\/jats:sup> arbitrary units (A.U) IQR 1.6*10<jats:sup>9<\/jats:sup>\u201314*10<jats:sup>9<\/jats:sup> in the ICG-<jats:sup>99m<\/jats:sup>Tc-nanocolloid group versus 4.6*10<jats:sup>9<\/jats:sup> A.U. IQR 2.4*10<jats:sup>9<\/jats:sup>\u201342*10<jats:sup>9<\/jats:sup> in the ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan group, <jats:italic>p<\/jats:italic> = 0.0054). This was consistent with a larger degree of \u201cstacked\u201d ICG observed in the nanoscan formulation. No tracer-related adverse events were reported.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Based on this retrospective analysis, we can conclude that ICG-<jats:sup>99m<\/jats:sup>Tc-nanoscan has similar capacity for SN identification as ICG-<jats:sup>99m<\/jats:sup>Tc-nanocolloid and can safely be implemented in SN procedures.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00259-023-06157-9","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:03:36Z","timestamp":1679011416000},"page":"2282-2291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of two hybrid sentinel node tracers: indocyanine green (ICG)-99mTc-nanocolloid vs. ICG-99mTc-nanoscan from a nuclear medicine and surgical perspective"],"prefix":"10.1007","volume":"50","author":[{"given":"Manon T. 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