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Myocardial infarction was induced by permanent ligation of the left anterior descending coronary artery in F344 athymic rats, and a triple-layered MEFs sheets were transplanted to the infarcted area two weeks after surgery. To validate the temporal tracking and kinetic analysis of the transplanted MEFs sheets, sequential cardiac single-photon emission computed tomography (SPECT) examinations with a <jats:sup>99m<\/jats:sup>TcO<jats:sub>4<\/jats:sub><jats:sup>\u2013<\/jats:sup> injection were performed. The cell sheets generated using MEFs of wild-type mice (WT) served as controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A significantly higher amount of <jats:sup>99m<\/jats:sup>TcO<jats:sub>4<\/jats:sub><jats:sup>\u2013<\/jats:sup> was taken into the hNIS-Tg MEFs than into WT MEFs (146.1\u2009\u00b1\u200930.9-fold). The obvious accumulation of <jats:sup>99m<\/jats:sup>TcO<jats:sub>4<\/jats:sub><jats:sup>\u2013<\/jats:sup> was observed in agreement with the region where hNIS-Tg MEFs were transplanted, and these radioactivities peaked 40\u201360\u00a0min after <jats:sup>99m<\/jats:sup>TcO<jats:sub>4<\/jats:sub><jats:sup>\u2013<\/jats:sup> administration. The volume of distribution of the hNIS-Tg MEF sheets declined gradually after transplantation, implying cellular malfunction and a loss in the number of transplanted cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The reporter gene imaging with hNIS enables the serial tracking and quantitative kinetic analysis of cell sheets transplanted to infarcted hearts.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00259-024-06889-2","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T11:02:51Z","timestamp":1724929371000},"page":"74-87","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-8056","authenticated-orcid":false,"given":"Kentaro","family":"Otani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Zeniya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuaki","family":"Moriguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Koshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Yamahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Inubushi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-3068","authenticated-orcid":false,"given":"Hidehiro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"6889_CR1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1161\/CIRCRESAHA.118.313568","volume":"124","author":"IY Elgendy","year":"2019","unstructured":"Elgendy IY, Mahtta D, Pepine CJ. 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