{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:31Z","timestamp":1791919711083,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2022ZD0213800"],"award-info":[{"award-number":["2022ZD0213800"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Science Foundation of China","award":["81801752"],"award-info":[{"award-number":["81801752"]}]},{"name":"the National Science Foundation of China","award":["82201583"],"award-info":[{"award-number":["82201583"]}]},{"name":"the National Science Foundation of China","award":["82171473"],"award-info":[{"award-number":["82171473"]}]},{"name":"the National Science Foundation of China","award":["82071962"],"award-info":[{"award-number":["82071962"]}]},{"name":"the Shanghai Sailing Program","award":["18YF1403200"],"award-info":[{"award-number":["18YF1403200"]}]},{"name":"the Shanghai Sailing Program","award":["19YF1405300"],"award-info":[{"award-number":["19YF1405300"]}]},{"name":"the startup fund of Huashan Hospital, Fudan University","award":["2017QD081"],"award-info":[{"award-number":["2017QD081"]}]},{"name":"the Shanghai Municipal Key Clinical Specialty","award":["3030247006"],"award-info":[{"award-number":["3030247006"]}]},{"name":"Clinical Research Plan of SHDC","award":["No. SHDC2020CR2056B"],"award-info":[{"award-number":["No. SHDC2020CR2056B"]}]},{"name":"the Shanghai Municipal Science and Technology Major Project","award":["No. 2018SHZDZX01"],"award-info":[{"award-number":["No. 2018SHZDZX01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00259-024-06993-3","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T03:09:34Z","timestamp":1732244974000},"page":"1510-1519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Presynaptic terminal integrity is associated with glucose metabolism in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"52","author":[{"given":"Weiyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-281X","authenticated-orcid":false,"given":"Fang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"issue":"6","key":"6993_CR1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","volume":"323","author":"MJ Armstrong","year":"2020","unstructured":"Armstrong MJ, Okun MS. Diagnosis and treatment of Parkinson Disease: a review. JAMA. 2020;323(6):548\u201360.","journal-title":"JAMA"},{"issue":"6","key":"6993_CR2","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/mds.23732","volume":"26","author":"AH Schapira","year":"2011","unstructured":"Schapira AH, Jenner P. Etiology and pathogenesis of Parkinson\u2019s disease. Mov Disord. 2011;26(6):1049\u201355.","journal-title":"Mov Disord"},{"issue":"2","key":"6993_CR3","doi-asserted-by":"publisher","first-page":"a009399","DOI":"10.1101\/cshperspect.a009399","volume":"2","author":"L Stefanis","year":"2012","unstructured":"Stefanis L. Alpha-synuclein in Parkinson\u2019s disease. Cold Spring Harb Perspect Med. 2012;2(2):a009399.","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"6993_CR4","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.2967\/jnumed.115.156067","volume":"56","author":"O Granert","year":"2015","unstructured":"Granert O, Drzezga AE, Boecker H, Perneczky R, Kurz A, Gotz J, et al. Metabolic topology of neurodegenerative disorders: influence of cognitive and motor deficits. J Nucl Med. 2015;56(12):1916\u201321.","journal-title":"J Nucl Med"},{"issue":"5","key":"6993_CR5","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/jcbfm.1994.99","volume":"14","author":"D Eidelberg","year":"1994","unstructured":"Eidelberg D, Moeller JR, Dhawan V, Spetsieris P, Takikawa S, Ishikawa T, et al. The metabolic topography of parkinsonism. J Cereb Blood Flow Metab. 1994;14(5):783\u2013801.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"6993_CR6","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1038\/s41467-019-09562-7","volume":"10","author":"SE Holmes","year":"2019","unstructured":"Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, et al. Lower synaptic density is associated with depression severity and network alterations. Nat Commun. 2019;10(1):1529.","journal-title":"Nat Commun"},{"issue":"5","key":"6993_CR7","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1002\/alz.13775","volume":"20","author":"K He","year":"2024","unstructured":"He K, Li B, Wang J, Wang Y, You Z, Chen X, et al. APOE epsilon4 is associated with decreased synaptic density in cognitively impaired participants. Alzheimers Dement. 2024;20(5):3157\u201366.","journal-title":"Alzheimers Dement"},{"issue":"9","key":"6993_CR8","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1038\/s41380-024-02501-z","volume":"29","author":"J Wang","year":"2024","unstructured":"Wang J, Huang Q, Chen X, You Z, He K, Guo Q, et al. Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer\u2019s disease. Mol Psychiatry. 2024;29(9):2799\u2013809.","journal-title":"Mol Psychiatry"},{"issue":"11","key":"6993_CR9","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1002\/mds.28216","volume":"35","author":"A Delva","year":"2020","unstructured":"Delva A, Van Weehaeghe D, Koole M, Van Laere K, Vandenberghe W. Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson\u2019s Disease. Mov Disord. 2020;35(11):1977\u201386.","journal-title":"Mov Disord"},{"issue":"3","key":"6993_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/ana.25682","volume":"87","author":"D Matuskey","year":"2020","unstructured":"Matuskey D, Tinaz S, Wilcox KC, Naganawa M, Toyonaga T, Dias M, et al. Synaptic changes in Parkinson Disease assessed with in vivo imaging. Ann Neurol. 2020;87(3):329\u201338.","journal-title":"Ann Neurol"},{"issue":"12","key":"6993_CR11","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, et al. MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov Disord. 2015;30(12):1591\u2013601.","journal-title":"Mov Disord"},{"key":"6993_CR12","doi-asserted-by":"publisher","first-page":"880407","DOI":"10.3389\/fneur.2022.880407","volume":"13","author":"H Takashima","year":"2022","unstructured":"Takashima H, Terada T, Bunai T, Matsudaira T, Obi T, Ouchi Y. In vivo illustration of altered dopaminergic and GABAergic Systems in Early Parkinson\u2019s Disease. Front Neurol. 2022;13:880407.","journal-title":"Front Neurol"},{"issue":"10","key":"6993_CR13","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1007\/s00259-021-05665-w","volume":"49","author":"Y Tang","year":"2022","unstructured":"Tang Y, Yu J, Zhou M, Li J, Long T, Li Y, et al. Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with (18)F-SynVesT-1 positron emission tomography imaging. Eur J Nucl Med Mol Imaging. 2022;49(10):3482\u201391.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"6993_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuroscience.2019.07.048","volume":"417","author":"J Su","year":"2019","unstructured":"Su J, Huang Q, Ren S, Xie F, Zhai Y, Guan Y, et al. Altered brain glucose metabolism assessed by (18)F-FDG PET imaging is Associated with the cognitive impairment of CADASIL. Neuroscience. 2019;417:35\u201344.","journal-title":"Neuroscience"},{"issue":"7","key":"6993_CR15","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00406-019-01083-0","volume":"270","author":"Q Huang","year":"2020","unstructured":"Huang Q, Ren S, Jiang D, Guan Y, Xie F, Sun D, et al. Changes in brain glucose metabolism and connectivity in somatoform disorders: an (18)F-FDG PET study. Eur Arch Psychiatry Clin Neurosci. 2020;270(7):881\u201391.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"6993_CR16","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.neuroimage.2016.12.077","volume":"147","author":"G Gonzalez-Escamilla","year":"2017","unstructured":"Gonzalez-Escamilla G, Lange C, Teipel S, Buchert R, Grothe MJ. Alzheimer\u2019s Disease Neuroimaging I. PETPVE12: an SPM toolbox for partial volume effects correction in brain PET - application to amyloid imaging with AV45-PET. NeuroImage. 2017;147:669\u201377.","journal-title":"NeuroImage"},{"issue":"15","key":"6993_CR17","doi-asserted-by":"publisher","first-page":"5768","DOI":"10.1088\/0031-9155\/61\/15\/5768","volume":"61","author":"G Akamatsu","year":"2016","unstructured":"Akamatsu G, Ikari Y, Ohnishi A, Nishida H, Aita K, Sasaki M, et al. Automated PET-only quantification of amyloid deposition with adaptive template and empirically pre-defined ROI. Phys Med Biol. 2016;61(15):5768\u201380.","journal-title":"Phys Med Biol"},{"issue":"7","key":"6993_CR18","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1093\/brain\/awz120","volume":"142","author":"A Martin-Bastida","year":"2019","unstructured":"Martin-Bastida A, Lao-Kaim NP, Roussakis AA, Searle GE, Xing Y, Gunn RN, et al. Relationship between neuromelanin and dopamine terminals within the Parkinson\u2019s nigrostriatal system. Brain. 2019;142(7):2023\u201336.","journal-title":"Brain"},{"issue":"10","key":"6993_CR19","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1002\/mds.27823","volume":"34","author":"YC Wong","year":"2019","unstructured":"Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, et al. Neuronal vulnerability in Parkinson disease: should the focus be on axons and synaptic terminals? Mov Disord. 2019;34(10):1406\u201322.","journal-title":"Mov Disord"},{"issue":"9","key":"6993_CR20","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1073\/pnas.1200575109","volume":"109","author":"M Lundblad","year":"2012","unstructured":"Lundblad M, Decressac M, Mattsson B, Bjorklund A. Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons. Proc Natl Acad Sci U S A. 2012;109(9):3213\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"6993_CR21","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1021\/acschemneuro.8b00526","volume":"10","author":"S Li","year":"2019","unstructured":"Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, et al. Synthesis and in vivo evaluation of a novel PET Radiotracer for imaging of synaptic vesicle glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem Neurosci. 2019;10(3):1544\u201354.","journal-title":"ACS Chem Neurosci"},{"key":"6993_CR22","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.brainres.2010.09.063","volume":"1367","author":"D Dardou","year":"2011","unstructured":"Dardou D, Dassesse D, Cuvelier L, Deprez T, De Ryck M, Schiffmann SN. Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system. Brain Res. 2011;1367:130\u201345.","journal-title":"Brain Res"},{"issue":"4","key":"6993_CR23","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1007\/s11682-014-9332-x","volume":"9","author":"NA Schwab","year":"2015","unstructured":"Schwab NA, Tanner JJ, Nguyen PT, Schmalfuss IM, Bowers D, Okun M, et al. Proof of principle: Transformation approach alters caudate nucleus volume and structure-function associations. Brain Imaging Behav. 2015;9(4):744\u201353.","journal-title":"Brain Imaging Behav"},{"issue":"8","key":"6993_CR24","doi-asserted-by":"publisher","first-page":"a013680","DOI":"10.1101\/cshperspect.a013680","volume":"4","author":"AA Alabi","year":"2012","unstructured":"Alabi AA, Tsien RW. Synaptic vesicle pools and dynamics. Cold Spring Harb Perspect Biol. 2012;4(8):a013680.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"6993_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0165-3806(96)00210-6","volume":"99","author":"GS Withers","year":"1997","unstructured":"Withers GS, George JM, Banker GA, Clayton DF. Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Brain Res Dev Brain Res. 1997;99(1):87\u201394.","journal-title":"Brain Res Dev Brain Res"},{"issue":"10291","key":"6993_CR26","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C. Parkinson\u2019s disease. Lancet. 2021;397(10291):2284\u2013303.","journal-title":"Lancet"},{"issue":"9","key":"6993_CR27","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1523\/JNEUROSCI.20-09-03214.2000","volume":"20","author":"DD Murphy","year":"2000","unstructured":"Murphy DD, Rueter SM, Trojanowski JQ, Lee VM. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci. 2000;20(9):3214\u201320.","journal-title":"J Neurosci"},{"issue":"8","key":"6993_CR28","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1002\/mds.28064","volume":"35","author":"H Wilson","year":"2020","unstructured":"Wilson H, Pagano G, de Natale ER, Mansur A, Caminiti SP, Polychronis S, et al. Mitochondrial complex 1, Sigma 1, and synaptic vesicle 2A in early drug-naive Parkinson\u2019s Disease. Mov Disord. 2020;35(8):1416\u201327.","journal-title":"Mov Disord"},{"issue":"1","key":"6993_CR29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s10020-021-00327-x","volume":"27","author":"SK Meles","year":"2021","unstructured":"Meles SK, Oertel WH, Leenders KL. Circuit imaging biomarkers in preclinical and prodromal Parkinson\u2019s disease. Mol Med. 2021;27(1):111.","journal-title":"Mol Med"},{"issue":"9","key":"6993_CR30","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1177\/0271678X211004312","volume":"41","author":"MK Chen","year":"2021","unstructured":"Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, et al. Comparison of [(11)C]UCB-J and [(18)F]FDG PET in Alzheimer\u2019s disease: a tracer kinetic modeling study. J Cereb Blood Flow Metab. 2021;41(9):2395\u2013409.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"6993_CR31","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1097\/MNM.0000000000000187","volume":"35","author":"A Nagaki","year":"2014","unstructured":"Nagaki A, Onoguchi M, Matsutomo N. Clinical validation of high-resolution image reconstruction algorithms in brain 18F-FDG-PET: effect of incorporating Gaussian filter, point spread function, and time-of-flight. Nucl Med Commun. 2014;35(12):1224\u201332.","journal-title":"Nucl Med Commun"},{"issue":"8","key":"6993_CR32","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.compmedimag.2012.09.001","volume":"36","author":"D Gutierrez","year":"2012","unstructured":"Gutierrez D, Montandon ML, Assal F, Allaoua M, Ratib O, Lovblad KO, et al. Anatomically guided voxel-based partial volume effect correction in brain PET: impact of MRI segmentation. Comput Med Imaging Graph. 2012;36(8):610\u20139.","journal-title":"Comput Med Imaging Graph"},{"issue":"9","key":"6993_CR33","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/mds.29148","volume":"37","author":"A Delva","year":"2022","unstructured":"Delva A, Van Laere K, Vandenberghe W. Longitudinal Positron Emission Tomography Imaging of Presynaptic Terminals in early Parkinson\u2019s Disease. Mov Disord. 2022;37(9):1883\u201392.","journal-title":"Mov Disord"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-024-06993-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-024-06993-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-024-06993-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T10:54:57Z","timestamp":1739962497000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00259-024-06993-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["6993"],"URL":"https:\/\/doi.org\/10.1007\/s00259-024-06993-3","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,22]]},"assertion":[{"value":"16 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol adhered to ethical guidelines and was approved by the Institutional Review Boards of Huashan Hospital, Fudan University. Written informed consent was obtained from all participants prior to their enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Fang Xie is an editor in this journal. Fang Xie serves as a consultant for Zentera Therapeutics (Shanghai) Co., Ltd. The other authors report no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}