{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:11:51Z","timestamp":1793308311898,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Odense University Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to advance our understanding of the neurobiology of healthy aging, which is crucial for improving quality of life and preventing age-related diseases. Despite its importance, a comprehensive investigation of this process has yet to be fully characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a hybrid PET\/MRI scanner to assess neurophysiological parameters in 80 healthy individuals aged 20\u201378. Cerebral amyloid-beta (A\u03b2) deposition and glucose metabolism were assessed using PET scans, while participants underwent simultaneous MRI scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found a positive correlation between A\u03b2-deposition and aging, and a negative correlation between glucose metabolism and aging. The insula showed the strongest negative correlation between glucose metabolism and age (Spearman\u2019s\n                      <jats:italic>r<\/jats:italic>\n                      = -0.683, 95% CI [-0.79, -0.54],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), while the posterior cingulate cortex had the strongest positive correlation between A\u03b2-deposition and age (Spearman\u2019s\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.479, 95% CI [0.28, 0.64],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). These results suggest a spatially dependent link between A\u03b2-deposition and metabolism in healthy older adults, indicating a compensatory mechanism in early Alzheimer\u2019s. Additionally, A\u03b2-deposition was linked to changes in interregional neural communication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study confirms previous findings on aging and offers new insights, particularly on the role of A\u03b2-deposition in healthy aging. We observed a linear increase in A\u03b2-deposition, alongside decreases in white matter integrity, cerebral blood flow, and glucose metabolism. Additionally, we identified a complex regional relationship between A\u03b2-deposition, glucose metabolism, and neural communication, possibly reflecting compensatory mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-025-07100-w","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T22:23:19Z","timestamp":1738362199000},"page":"2267-2278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-3098","authenticated-orcid":false,"given":"Laust Vind","family":"Knudsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-6336","authenticated-orcid":false,"given":"Tanja Maria","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziba Ahangarani","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-7142","authenticated-orcid":false,"given":"Manouchehr Seyedi","family":"Vafaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"key":"7100_CR1","doi-asserted-by":"crossref","unstructured":"McDonald RB. 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