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Establishing DP pipelines is a non-trivial task, mainly driven by purely mathematical rules and done by data scientists. Nevertheless, clinician presence shall be paramount at this step. The study proposes a data preprocessing approach driven by clinical domain knowledge, where clinician input, in form of explicit and non-explicit rules, directly impacts the algorithms\u2019 decision-making processes, thus, making the DP planning phase more inclusive for clinicians.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The rule set table (RST) was introduced as interface which accepts clinician\u2019s input as formal rules (including four actions: exp-keep, exp-remove, pref-keep, pref-remove features or samples) in human-readable form and translates it to machine readable input for preprocessing algorithms. A collection of commonly used algorithms was incorporated for data preprocessing of various clinical cohorts in both single and multi-center scenarios. The impact of RST was evaluated by utilizing 100-fold Monte Carlo cross-validation scheme for prostate and glioma cohorts (single center) with 80\u2009\u2212\u200920% training-testing split. Furthermore, diffuse large B-cell lymphoma (DLBCL) cohort was evaluated by using Center 1 as training and Center 2 as testing cohort for clinical endpoint prediction. Both scenarios were investigated in manual and automated data preprocessing setups across all cohorts. The XGBoost algorithm was employed for classification tasks across all established models. Predictive performance was estimated by confusion matrix analysis in validation samples of all cohorts. The performance of RST across all actions as well as without RST were compared in both manual and automated settings for each respective cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Performance increase of ML models with manual preprocessing combined with RST was up-to 18% balanced accuracy (BACC) compared to models without RST. The ML models with \u201cexp-keep\u201d and \u201cpref-keep\u201d instructions showed highest performance increase of +\u200918% BACC (glioma), +\u20096% BACC (prostate) and +\u20093% BACC (DLBCL) compared to other models across all datasets.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The study demonstrated the added value of RST in predictive performance of oncology-specific ML models, hence, serving as proof of concept of a more inclusive clinician-driven DP process in future studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00259-025-07183-5","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T10:03:30Z","timestamp":1741341810000},"page":"3444-3454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinician-driven automated data preprocessing in nuclear medicine AI environments"],"prefix":"10.1007","volume":"52","author":[{"given":"Denis","family":"Krajnc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens P.","family":"Spielvogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boglarka","family":"Ecsedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsombor","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-9989","authenticated-orcid":false,"given":"Laszlo","family":"Papp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"7183_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ejmp.2021.04.016","volume":"83","author":"A Barrag\u00e1n-Montero","year":"2021","unstructured":"Barrag\u00e1n-Montero A, Javaid U, Vald\u00e9s G, Nguyen D, Desbordes P, Macq B, et al. 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