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Dr. Brugarolas\u2019 interests were reviewed and are managed by Massachusetts General Hospital (MGH) and Mass General Brigham in accordance with their conflict-of-interest policies.\u00a0All other authors have no potential conflicts of interest to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Studies in human research subjects were performed in line with the principles of the Declaration of Helsinki. Prior approval was granted by the Institutional Review Board (IRB) at the Massachusetts General Hospital (IRB# 2020P002459, PI: Brugarolas). The study was registered in ClinicalTrials.gov (NCT04699747, Sponsor: Massachusetts General Hospital, Responsible Party: P. Brugarolas). [\n                      18\n                      F]3F4AP was administered under an investigational new drug (IND) authorization from the U.S. Food and Drug Administration (FDA) (IND # 135,532, Sponsor: Brugarolas).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}