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Written informed consent was obtained from all patients and their spouses or other close family members. The study was registered with the UMIN Clinical Trials Registry (UMIN-CTR; number 000043458).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"H.S. (Hitoshi Shimada), M.-R.Z., and M.H. hold patents on compounds related to the present report (JP5422782 \/ EP 12 884 742.3 \/ CA2894994 \/ HK1208672). A.K. (Akihiko Kitamura), H.K., M.K., M.T., and K.N.are employed by Ajinomoto Co. Inc. The remaining authors conducted research funded by Ajinomoto Co.Inc. The authors declare that they have no other competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not commissioned; externally peer-reviewed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Provenance and peer review"}}]}}