{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:48:44Z","timestamp":1773164924455,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00259-025-07581-9","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T03:25:12Z","timestamp":1759721112000},"page":"1406-1418","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The clinical utility of total-body [68\u00a0Ga]Ga-PSMA-11 PET\/CT in prostate cancer: identifying extra-regional bone metastases and informing treatment strategies"],"prefix":"10.1007","volume":"53","author":[{"given":"Qiaochu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"1","key":"7581_CR1","first-page":"7","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7\u201333.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"7581_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12885-017-3922-0","volume":"18","author":"RK Hernandez","year":"2018","unstructured":"Hernandez RK, Wade SW, Reich A, et al. Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States. BMC Cancer. 2018;18(1):44.","journal-title":"BMC Cancer"},{"key":"7581_CR3","unstructured":"Mottet N, Cornford P, van den Bergh RCN, et al. EAU, EANM, ESTRO, ESUR, ISUP, SIOG guidlines on prostate cancer. EAU guidelines presented at the EAU Annual Congress Milan 2023. ISBN 978\u201394\u201392671\u201319\u20136."},{"issue":"17","key":"7581_CR4","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1200\/JCO.19.02757","volume":"38","author":"EJ Trabulsi","year":"2020","unstructured":"Trabulsi EJ, Rumble RB, Jadvar H, et al. Optimum imaging strategies for advanced prostate cancer: ASCO guideline. J Clin Oncol. 2020;38(17):1963.","journal-title":"J Clin Oncol"},{"key":"7581_CR5","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1038\/s41416-018-0323-3","volume":"119","author":"F Preisser","year":"2018","unstructured":"Preisser F, Mazzone E, Nazzani S, et al. North American population-based validation of the National Comprehensive Cancer Network practice guideline recommendations for locoregional lymph node and bone imaging in prostate cancer patients. Br J Cancer. 2018;119:1552\u20136.","journal-title":"Br J Cancer"},{"issue":"6","key":"7581_CR6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1053\/j.semnuclmed.2009.05.003","volume":"39","author":"M Beheshti","year":"2009","unstructured":"Beheshti M, Langsteger W, Fogelman I. Prostate cancer: role of SPECT and PET in imaging bone metastases. Semin Nucl Med. 2009;39(6):396\u2013407.","journal-title":"Semin Nucl Med"},{"issue":"1","key":"7581_CR7","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.eururo.2023.03.001","volume":"84","author":"KM Chow","year":"2023","unstructured":"Chow KM, So WZ, Lee HJ, et al. Head-to-head comparison of the diagnostic accuracy of prostate-specific membrane antigen positron emission tomography and conventional imaging modalities for initial staging of intermediate- to high-risk prostate cancer: a systematic review and meta-analysis. Eur Urol. 2023;84(1):36\u201348.","journal-title":"Eur Urol"},{"issue":"3","key":"7581_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/bju.14856","volume":"124","author":"GJR Cook","year":"2019","unstructured":"Cook GJR, Kulkarni M, Warbey VS. PSMA PET\/CT imaging for primary staging of intermediate and high-risk prostate cancer. BJU Int. 2019;124(3):357\u20138.","journal-title":"BJU Int"},{"issue":"5","key":"7581_CR9","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1007\/s00259-022-06089-w","volume":"50","author":"WP Fendler","year":"2023","unstructured":"Fendler WP, Eiber M, Beheshti M, et al. PSMA PET\/CT: joint EANM procedure guideline\/SNMMI procedure standard for prostate cancer imaging 2.0. Eur J Nucl Med Mol Imaging. 2023;50(5):1466\u201386.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"7581_CR10","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1148\/rg.2018170108","volume":"38","author":"MS Hofman","year":"2018","unstructured":"Hofman MS, Hicks RJ, Maurer T, Eiber M. Prostate-specific membrane antigen PET: clinical utility in prostate cancer, normal patterns, pearls, and pitfalls. Radiographics. 2018;38:200\u201317.","journal-title":"Radiographics"},{"issue":"3","key":"7581_CR11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2967\/jnumed.119.230318","volume":"61","author":"KL Pomykala","year":"2020","unstructured":"Pomykala KL, Czernin J, Grogan TR, et al. Total-body 68Ga-PSMA-11 PET\/CT for bone metastasis detection in prostate cancer patients: potential impact on bone scan guidelines. J Nucl Med. 2020;61(3):405\u201311.","journal-title":"J Nucl Med"},{"issue":"3","key":"7581_CR12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1109\/TRPMS.2020.2985403","volume":"4","author":"S Surti","year":"2020","unstructured":"Surti S, Pantel AR, Karp JS. Total body PET: why, how, what for? IEEE Trans Radiat Plasma Med Sci. 2020;4(3):283\u201392.","journal-title":"IEEE Trans Radiat Plasma Med Sci"},{"issue":"6","key":"7581_CR13","doi-asserted-by":"publisher","first-page":"861","DOI":"10.2967\/jnumed.120.250597","volume":"62","author":"BA Spencer","year":"2021","unstructured":"Spencer BA, Berg E, Schmall JP, et al. Performance evaluation of the uEXPLORER total-body PET\/CT scanner based on NEMA NU 2\u20132018 with additional tests to characterize PET scanners with a long axial field of view. J Nucl Med. 2021;62(6):861\u201370.","journal-title":"J Nucl Med"},{"key":"7581_CR14","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1007\/s00259-017-3780-7","volume":"44","author":"S Sheikhbahaei","year":"2017","unstructured":"Sheikhbahaei S, Afshar-Oromieh A, Eiber M, Solnes LB, Javadi MS, Ross AE, et al. Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging. Eur J Nucl Med Mol Imaging. 2017;44:2117\u201336.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"12","key":"7581_CR15","first-page":"1288","volume":"20","author":"EM Schaeffer","year":"2022","unstructured":"Schaeffer EM, Srinivas S, Adra N, et al. NCCN Guidelines\u00ae Insights: Prostate Cancer, Version 1.2023. J Natl Compr Canc Netw. 2022;20(12):1288\u201398.","journal-title":"J Natl Compr Canc Netw"},{"key":"7581_CR16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41585-022-00618-w","volume":"19","author":"Y Wang","year":"2022","unstructured":"Wang Y, Galante JR, Haroon A, et al. The future of PSMA PET and WB MRI as next-generation imaging tools in prostate cancer. Nat Rev Urol. 2022;19:475\u201393.","journal-title":"Nat Rev Urol"},{"issue":"12","key":"7581_CR17","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.2967\/jnumed.117.193581","volume":"58","author":"S Schmuck","year":"2017","unstructured":"Schmuck S, von Klot CA, Henkenberens C, et al. Initial experience with volumetric 68Ga-PSMA i&t PET\/CT for assessment of whole-body tumor burden as a quantitative imaging biomarker in patients with prostate cancer. J Nucl Med. 2017;58(12):1962\u20138.","journal-title":"J Nucl Med"},{"issue":"1","key":"7581_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1200\/OP.21.00206","volume":"18","author":"N Sayegh","year":"2022","unstructured":"Sayegh N, Swami U, Agarwal N. Recent advances in the management of metastatic prostate cancer. JCO Oncol Pract. 2022;18(1):45\u201355.","journal-title":"JCO Oncol Pract"},{"key":"7581_CR19","doi-asserted-by":"publisher","unstructured":"Chakrabarti D, Albertsen P, Adkins A, et al. The contemporary management of prostate cancer. CA Cancer J Clin. 2025. https:\/\/doi.org\/10.3322\/caac.70020","DOI":"10.3322\/caac.70020"},{"issue":"6","key":"7581_CR20","first-page":"349","volume":"10","author":"F Bois","year":"2020","unstructured":"Bois F, Noirot C, Dietemann S, et al. [Ga]Ga-PSMA-11 in prostate cancer: a comprehensive review. Am J Nucl Med Mol Imaging. 2020;10(6):349\u201374.","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"7581_CR21","first-page":"463","volume":"15","author":"B Saboury","year":"2020","unstructured":"Saboury B, Morris MA, Nikpanah M, et al. Reinventing Molecular Imaging with Total-Body PET. Part II: Clinical Applications PET Clin. 2020;15:463\u201375.","journal-title":"Part II: Clinical Applications PET Clin"},{"key":"7581_CR22","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1007\/s00259-023-06355-5","volume":"50","author":"Y Wang","year":"2023","unstructured":"Wang Y, Chen Z, Zhu Y, et al. Total-body [(68) Ga]Ga-PSMA-11 PET\/CT improves detection rate compared with conventional [(68) Ga]Ga-PSMA-11 PET\/CT in patients with biochemical recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2023;50:4096\u2013106.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"6","key":"7581_CR23","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1007\/s00259-020-05091-4","volume":"48","author":"H Tan","year":"2021","unstructured":"Tan H, Sui X, Yin H, et al. Total-body PET\/CT using half-dose FDG and compared with conventional PET\/CT using full-dose FDG in lung cancer. Eur J Nucl Med Mol Imaging. 2021;48(6):1966\u201375.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"7581_CR24","doi-asserted-by":"publisher","unstructured":"Spiridon IA, Ong SLM, Soukup J, Topirceanu-Andreoiu OM, et al. Neovascular prostate specific membrane antigen (PSMA) expression in bone and soft tissue sarcoma: a systematic analysis. Virchows Arch. 2025. https:\/\/doi.org\/10.1007\/s00428-025-04086-6","DOI":"10.1007\/s00428-025-04086-6"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-025-07581-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-025-07581-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-025-07581-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:43:30Z","timestamp":1769834610000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00259-025-07581-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["7581"],"URL":"https:\/\/doi.org\/10.1007\/s00259-025-07581-9","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study involving human participants obtained ethical clearance and adhered to the ethical principles outlined by the ethics committee at Renji Hospital and the Declaration of Helsinki of 1964. This research did not involve animal subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All participants provided informed consent prior to undergoing the examination procedures.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"No potential conflict of interest was reported.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}