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The study was approved by the SingHealth Centralised Institutional Review Board (CIRB 2021\/2190).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent for study participation, and for the use of biospecimens and clinical data was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The funders of the study and SOFIE Pharmaceuticals had no role in the study design, data collection, data analysis, data interpretation or writing of the manuscript. AHLL reports a relationship with Boehringer Ingelheim GmbH that includes consulting or advisory, funding grants, speaking and lecture fees, and travel reimbursement; and a relationship with Novartis Pharmaceuticals that includes speaking and lecture fees and travel reimbursement. WWCL reports a relationship with Novartis Pharmaceuticals that includes consulting or advisory, speaking and lecture fees. The other authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}