{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:09:42Z","timestamp":1792404582320,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00259-025-07718-w","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:54:00Z","timestamp":1767596040000},"page":"3351-3363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aortic valve calcium score from computed tomography for signal localization by cardiac amyloid radionuclide imaging to predict aortic stenosis and assess prognosis in patients with transthyretin cardiomyopathy"],"prefix":"10.1007","volume":"53","author":[{"given":"Guillaume","family":"Bonnans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Cariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Legallois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Malerbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Cazalbou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoan","family":"Lavie-Badie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Cassol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Beaurain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Manrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8141-6582","authenticated-orcid":false,"given":"Olivier","family":"Lairez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Toulouse Amyloidosis Research Network collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Alric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Chauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Cintas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Colombat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Dupin-Deguine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Huart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Puissant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Pugnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Pr\u00e9vot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ribes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sailler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"7718_CR1","doi-asserted-by":"publisher","first-page":"e005066","DOI":"10.1161\/CIRCIMAGING.116.005066","volume":"9","author":"TA Treibel","year":"2016","unstructured":"Treibel TA, Fontana M, Gilbertson JA, Castelletti S, White SK, Scully PR, et al. Occult transthyretin cardiac amyloid in severe calcific aortic stenosis: prevalence and prognosis in patients undergoing surgical aortic valve replacement. Circ Cardiovasc Imaging. 2016;9:e005066.","journal-title":"Circ Cardiovasc Imaging."},{"key":"7718_CR2","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","volume":"38","author":"A Castano","year":"2017","unstructured":"Castano A, Narotsky DL, Hamid N, Khalique OK, Morgenstern R, DeLuca A, et al. Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur Heart J. 2017;38:2879\u201387.","journal-title":"Eur Heart J"},{"issue":"5","key":"7718_CR3","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.jcin.2012.03.012","volume":"5","author":"F Nietlispach","year":"2012","unstructured":"Nietlispach F, Webb JG, Ye J, Cheung A, Lichtenstein SV, Carere RG, et al. Pathology of transcatheter valve therapy. JACC Cardiovasc Interv. 2012;5(5):582\u201390.","journal-title":"JACC Cardiovasc Interv"},{"key":"7718_CR4","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1016\/j.jacc.2019.09.056","volume":"74","author":"J Ternacle","year":"2019","unstructured":"Ternacle J, Krapf L, Mohty D, Magne J, Nguyen A, Galat A, et al. Aortic Stenosis and Cardiac Amyloidosis: JACC Review Topic of the Week. J Am Coll Cardiol. 2019;74:2638\u201351.","journal-title":"J Am Coll Cardiol"},{"key":"7718_CR5","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","volume":"43","author":"A Vahanian","year":"2022","unstructured":"Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, et al. 2021 ESC\/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43:561\u2013632.","journal-title":"Eur Heart J"},{"key":"7718_CR6","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","volume":"133","author":"JD Gillmore","year":"2016","unstructured":"Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation. 2016;133:2404\u201312.","journal-title":"Circulation"},{"key":"7718_CR7","first-page":"864","volume":"30","author":"FG Hage","year":"2023","unstructured":"Hage FG, Einstein AJ, Ananthasubramaniam K, Bourque JM, Case J, DePuey EG, et al. Quality metrics for single-photon emission computed tomography myocardial perfusion imaging: an ASNC information statement. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. 2023;30:864\u2013907.","journal-title":"J Nucl Cardiol Off Publ Am Soc Nucl Cardiol"},{"key":"7718_CR8","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.jacc.2005.05.073","volume":"46","author":"E Perugini","year":"2005","unstructured":"Perugini E, Guidalotti PL, Salvi F, Cooke RMT, Pettinato C, Riva L, et al. Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy. J Am Coll Cardiol. 2005;46:1076\u201384.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"7718_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","volume":"16","author":"J-U Voigt","year":"2015","unstructured":"Voigt J-U, Pedrizzetti G, Lysyansky P, Marwick TH, Houle H, Baumann R, et al. Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging. 2015;16(1):1\u201311.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"7718_CR10","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/ehjci\/jew335","volume":"18","author":"HC Baumgartner","year":"2017","unstructured":"Baumgartner HC, Hung JC-C, Bermejo J, Chambers JB, Edvardsen T, Goldstein S, et al. Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2017;18:254\u201375.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"7718_CR11","first-page":"101232","volume":"3","author":"G Tini","year":"2024","unstructured":"Tini G, Cristiano E, Zampieri M, Ponziani A, Porcari A, Zanoletti M, et al. Impact of the noninvasive diagnostic algorithm on clinical presentation and prognosis in cardiac amyloidosis. JACC: Advances. 2024;3:101232.","journal-title":"JACC: Advances"},{"key":"7718_CR12","doi-asserted-by":"publisher","first-page":"e034723","DOI":"10.1161\/JAHA.124.034723","volume":"13","author":"M-S Annabi","year":"2024","unstructured":"Annabi M-S, Carter-Storch R, Zaroui A, Galat A, Oghina S, Kharoubi M, et al. Prevalence, characteristics, and impact on prognosis of aortic stenosis in patients with cardiac amyloidosis. J Am Heart Assoc. 2024;13:e034723.","journal-title":"J Am Heart Assoc"},{"key":"7718_CR13","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/joim.20042","volume":"297","author":"M-A Delbarre","year":"2025","unstructured":"Delbarre M-A, Chadha GD, Annabi M-S, Nouri R, Zaroui A, Blanc-Durand P, et al. Wild-type transthyretin cardiac amyloidosis and aortic stenosis: can carpal tunnel syndrome help distinguish the chicken from the egg? J Intern Med. 2025;297:186\u2013200.","journal-title":"J Intern Med"},{"key":"7718_CR14","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1002\/ehf2.13876","volume":"9","author":"F Cannata","year":"2022","unstructured":"Cannata F, Chiarito M, Pinto G, Villaschi A, Sanz-S\u00e1nchez J, Fazzari F, et al. <article-title update=\"added\">Transcatheter aortic valve replacement in aortic stenosis and cardiac amyloidosis: a systematic review and meta\u2010analysis. ESC Heart Failure. 2022;9:3188\u201397.","journal-title":"ESC Heart Failure"},{"key":"7718_CR15","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1093\/eurheartj\/ehw033","volume":"37","author":"A Galat","year":"2016","unstructured":"Galat A, Guellich A, Bodez D, Slama M, Dijos M, Zeitoun DM, et al. Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg? Eur Heart J. 2016;37:3525\u201331.","journal-title":"Eur Heart J"},{"key":"7718_CR16","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.carpath.2009.04.005","volume":"19","author":"AV Kristen","year":"2010","unstructured":"Kristen AV, Schnabel PA, Winter B, Helmke BM, Longerich T, Hardt S, et al. <article-title update=\"added\">High prevalence of amyloid in 150 surgically removed heart valves\u2014a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions. Cardiovasc Pathol. 2010;19:228\u201335.","journal-title":"Cardiovasc Pathol"},{"key":"7718_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2024.107674","volume":"73","author":"J-B Brette","year":"2024","unstructured":"Brette J-B, Colombat M, Fournier P, Moninhas M, Marcheix B, Lairez O, et al. Descriptive study of the clinical and myocardial status of a population with anatomopathological aortic valve amyloidosis. Cardiovasc Pathol. 2024;73:107674.","journal-title":"Cardiovasc Pathol"},{"key":"7718_CR18","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","volume":"38","author":"A Casta\u00f1o","year":"2017","unstructured":"Casta\u00f1o A, Narotsky DL, Hamid N, Khalique OK, Morgenstern R, DeLuca A, et al. Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur Heart J. 2017;38:2879\u201387.","journal-title":"Eur Heart J"},{"key":"7718_CR19","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1016\/j.jaccas.2020.10.002","volume":"2","author":"M Hussain","year":"2020","unstructured":"Hussain M, Hanna M, Rodriguez L, Griffin B, Watson C, Phelan D, et al. Subthreshold aortic valve calcium scores in severe aortic stenosis and transthyretin cardiac amyloidosis. JACC Case reports. 2020;2:2205\u20139.","journal-title":"JACC Case reports"},{"key":"7718_CR20","doi-asserted-by":"crossref","unstructured":"Hussain M, Hanna M, Griffin BP, Conic J, Patel J, Fava AM, et al. Aortic valve calcium in patients with transthyretin cardiac amyloidosis: a propensity-matched analysis. Circ. Cardiovasc. Imaging. United States; 2020; e011433.","DOI":"10.1161\/CIRCIMAGING.120.011433"},{"key":"7718_CR21","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","volume":"15","author":"AS Agatston","year":"1990","unstructured":"Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte MJ, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827\u201332.","journal-title":"J Am Coll Cardiol"},{"key":"7718_CR22","doi-asserted-by":"publisher","first-page":"4459","DOI":"10.1007\/s00330-023-10439-z","volume":"34","author":"M Osborne-Grinter","year":"2024","unstructured":"Osborne-Grinter M, Ali A, Williams MC. Prevalence and clinical implications of coronary artery calcium scoring on non-gated thoracic computed tomography: a systematic review and meta-analysis. Eur Radiol. 2024;34:4459\u201374.","journal-title":"Eur Radiol"},{"key":"7718_CR23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.124.017122","volume":"18","author":"NSB Mogensen","year":"2025","unstructured":"Mogensen NSB, Sanchez Dahl J, Ali M, Annabi M-S, Haujir A, Powers A, et al. Usefulness of aortic valve calcification in patients with low-flow aortic stenosis. Circ Cardiovasc Imaging. 2025;18:e017122.","journal-title":"Circ Cardiovasc Imaging"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-025-07718-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-025-07718-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-025-07718-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T01:26:34Z","timestamp":1774401994000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00259-025-07718-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["7718"],"URL":"https:\/\/doi.org\/10.1007\/s00259-025-07718-w","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"12 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was performed in accordance with the ethical standards as laid down in the\u00a01964 Declaration of Helsinki\u00a0and its later amendments.According to the French ethics and regulatory law (public health code) for retrospective studies, the exploitation of usual care data is covered by reference methodology of the French National Commission for Informatics and Liberties (CNIL). This study is covered by the reference methodology 004. All patients were informed of the protocol and of the use of their data, which they did not oppose. This study was approved by the Toulouse University Hospital review board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The study has been registered in the register of retrospective study of the Toulouse University Hospital (reference RnIPH 2025\u201343).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"Eve Cariou reports speaking\/consulting fees from Alnylam Pharmaceuticals, AstraZeneca, Bayer, Pfizer, Sanofi-Genzyme.St\u00e9phanie Cazalbou reports speaking\/consulting fees from Pfizer.Pauline Fournier reports speaking\/consulting fees from Pfizer.Olivier Lairez reports speaking\/consulting fees from Alnylam Pharmaceuticals, Amicus Therapeutics, AstraZeneca, Bayer, BMS, Pfizer, Sanofi-Genzyme, Siemens Healthineers.Yoan Lavie-Badie reports speaking\/consulting fees from Abbott, Edwards, General Electric, Siemens Healthineers.Damien Legallois reports speaking\/consulting fees from Astrazeneca, Bayer, Boehringer Ingelheim, Lilly, Pfizer, Takeda.Alain Manrique reports speaking\/consulting fees from Pfizer.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}