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ASL image interpretability, concordance with [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET, and value of Z-score maps were rated visually. Regional associations of CBF with [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG uptake ratio (SUVr) were investigated by univariate regression and mixed linear models. Also influences of age, disease stage and vascular pathology on ASL interpretability and concordance, and whole cortex spatial coefficient of variation (sCOV) were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ASL CBF maps were non-comparable to [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET, i.e. uninterpretable or discordant, in 53% of patients, 37% of elderly controls, and 8% of young controls. Only 14% of patient ASL MRI scans were concordant with [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET. Z-score maps were mainly of value in partially concordant scans. Increasing sCOV was strongly associated both with disease severity and with decreasing ASL interpretability and concordance, and allowed for identification of uninterpretable scans with 95% sensitivity and 90% specificity. Whole cortex CBF and [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG SUVr values showed similar distribution across groups, but low to moderate regional associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Multi-PLD ASL provided quantitative CBF measurements correlating with disease severity, but poor image quality and low regional concordance in head-to-head comparison with [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET imaging restricts the clinical use in memory clinic patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-025-07736-8","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T02:03:22Z","timestamp":1768183402000},"page":"3408-3421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Simultaneous multiple post-labelling delay ASL MRI and [18F]FDG PET in a mixed memory clinic population and healthy controls"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0472-015X","authenticated-orcid":false,"given":"Otto M.","family":"Henriksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-9204","authenticated-orcid":false,"given":"Oriol P.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9054-054X","authenticated-orcid":false,"given":"Frederik J.","family":"Bruun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-1035","authenticated-orcid":false,"given":"Marie","family":"Bruun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-4911","authenticated-orcid":false,"given":"Steen G.","family":"Hasselbalch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-4417","authenticated-orcid":false,"given":"Kristian S.","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-1537","authenticated-orcid":false,"given":"Adam E.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-7496","authenticated-orcid":false,"given":"Ian","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-6354","authenticated-orcid":false,"given":"Ulrich","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"7736_CR1","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.2967\/jnumed.121.263194","volume":"63","author":"S Minoshima","year":"2022","unstructured":"Minoshima S, Cross D, Thientunyakit T, Foster NL, Drzezga A. 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Retrospective use of clinical data was approved by the Danish Patient Safety Authority. (3-3013-3144\/1).Healthy volunteers participated in prospective studies approved by the local ethics committee (H-18035941, H-1-2014-126, and H-16023156) conducted in accordance with the Helsinki","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Both patients and volunteers gave informed written consent prior to the scan.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/Competing interests"}}]}}