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This study aimed to develop and validate a radiomics-based predictive model for OLNM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials\/Methods<\/jats:title>\n                    <jats:p>\n                      A radiomics model (Model\n                      <jats:sub>PET<\/jats:sub>\n                      ) and a model (Model\n                      <jats:sub>Combined<\/jats:sub>\n                      ) combining radiomics and clinical features were developed using a retrospective monocentric cohort of localized NSCLC patients treated with surgery (Cohort A) and tested on an external cohort (Cohort B) of 112 localized NSCLC patients also treated with surgery (publicly available Radiogenomics cohort). The model was further assessed in an independent cohort of 488 patients with localized NSCLC who underwent definitive stereotactic body radiotherapy (SBRT) (Cohort C) using regional relapse free survival (RRFS) as a surrogate for OLNM. Radiomic features were extracted from pre-treatment FDG PET and combined to predict OLNM using a multilayer perceptron approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the training cohort, the Model\n                      <jats:sub>PET<\/jats:sub>\n                      and Model\n                      <jats:sub>Combined<\/jats:sub>\n                      achieved AUCs of 0.92\/0.99 and balanced accuracies (Bacc) of 80.0%\/85.3%, respectively. In the Cohort B, the Model\n                      <jats:sub>PET<\/jats:sub>\n                      and Model\n                      <jats:sub>Combined<\/jats:sub>\n                      resulted in AUCs of 0.73\/0.67 and Baccs of 71.2%\/51.7%, respectively. In the Cohort C, the predicted OLNM risk based on Model\n                      <jats:sub>PET<\/jats:sub>\n                      was significantly associated with worse RFFS (HR 1.60 95% CI 1.03\u20132.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). The Model\n                      <jats:sub>Combined<\/jats:sub>\n                      was not associated with survival outcomes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study presents a radiomics-based predictive model for OLNM in localized NSCLC, validated across several retrospective independent cohorts. Subject to a prospective evaluation, the model could be used to refine clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-025-07740-y","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:27:53Z","timestamp":1768537673000},"page":"3838-3848","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and external validation of a FDG PET-based radiomics model predicting occult lymph node metastasis in non-small cell lung cancer patients"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-0029","authenticated-orcid":false,"given":"Vincent","family":"Bourbonne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lovinfosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Geier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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