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(Biograph Vision Quadra\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Siemens Healthineers; acquisition 5\/15\/30 min). Standardised uptake values (SUV) of lymphoma, benign lymph nodes, organs and reference tissues were quantified and multi time-point kinetics were described using Retention Indices (RI) and linear\/quadratic trajectory analyses. Image quality was rated by two blinded readers on a 5-point Likert scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Image quality remained diagnostic in all datasets. Median Tumour-to-Background Ratio (TBR) increased significantly from 4.1 (1\u00a0h p.i.) to 12.5 (3\u00a0h p.i.) and 23.9 (6\u00a0h p.i.),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. High-grade lymphoma exhibited an almost linear SUV rise, whereas low-grade entities followed a parabolic course, peaking at 3\u00a0h p.i. Benign lymph nodes demonstrated constant uptake (1\u00a0h: 0.9\u2009\u00b1\u20090.3, 3\u00a0h: 0.8\u2009\u00b1\u20090.5, 6\u00a0h: 0.8\u2009\u00b1\u20090.4). RIs showed a significant increase in [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG uptake over time in lymphoma, compared with a decline in benign lymph nodes (1\u20133\u00a0h p.i.: 19.4% vs. -14.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The LAFOV scanner enables high-quality [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET imaging for up to 6\u00a0h p.i., with a six-fold increase of TBR in ultra-late scans 6\u00a0h p.i. Extended [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG kinetic analysis differentiates high- and low-grade lymphomas from benign lymph nodes and reveals a significant decline in tracer uptake in low-grade lymphomas between 3 and 6 h p.i.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>DRKS00027307. Registered 26 November 2021.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-026-07774-w","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:59:12Z","timestamp":1770789552000},"page":"4494-4505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring extended [18F]FDG kinetics in lymphoma with ultra-late LAFOV-PET\/CT"],"prefix":"10.1007","volume":"53","author":[{"given":"Matthias","family":"Weissinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ursprung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Jacoby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"G\u00fcckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schwenck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Dittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Nikolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian la","family":"Foug\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Philipp","family":"Reinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"issue":"27","key":"7774_CR1","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1200\/JCO.2013.53.5229","volume":"32","author":"SF Barrington","year":"2014","unstructured":"Barrington SF, et al. 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Approval was granted by the Ethics Committee of University of Tuebingen (Registry no. 704\/2021BO1).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figs.\u00a02 and 5.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Christian la Foug\u00e8re and Fabian Schmidt have received research support from Siemens. All other authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}