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In this study, we examined how tau accumulation relates to verbal and visual memory performance, and whether these associations show a preference for one hemisphere of the brain over the other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We administered the Rey Auditory Verbal Learning Test (RAVLT) and its nonverbal analog, the Aggie Figures Learning Test (AFLT), to 132 cognitively unimpaired elderly participants and 44 cognitively impaired, amyloid-positive individuals from the Translational Biomarkers in Aging and Dementia cohort. All participants underwent [18\u00a0F]MK6240 tau PET, [18\u00a0F]AZD4694 amyloid PET, and structural MRI scans. We analyzed the data using region-of-interest and voxel-wise regression models, as well as correlation analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Voxel-wise analyses showed that higher tau load in the right hemisphere was associated with worse visual memory, confirming a lateralized relationship. Left-hemisphere tau associations with verbal memory were observed at higher t-values. In regression models including both memory scores, visual memory remained significantly associated with tau on the right hemisphere (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>AFLT~Rtau<\/jats:italic>\n                      <\/jats:sub>\n                      =-0.22,\n                      <jats:italic>p<\/jats:italic>\n                      =0.001;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>RAVLT~Rtau<\/jats:italic>\n                      <\/jats:sub>\n                      =-0.1,\n                      <jats:italic>p<\/jats:italic>\n                      =0.13), whereas both visual and verbal memory remained significant on the left hemisphere (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>AFLT~Ltau<\/jats:italic>\n                      <\/jats:sub>\n                      =-0.16,\n                      <jats:italic>p<\/jats:italic>\n                      =0.03;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>RAVLT~Ltau<\/jats:italic>\n                      <\/jats:sub>\n                      =-0.14,\n                      <jats:italic>p<\/jats:italic>\n                      =0.04). These patterns were also reflected in Braak regions, except for Braak I, where only left tau\u2013verbal and right tau\u2013visual associations remained significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support lateralized associations between tau accumulation and memory deficits, with visual memory linked to right-hemisphere tau and verbal memory to left-hemisphere tau. This pattern is consistent with lateralization of memory functions observed in other neurological conditions and highlights the importance of considering hemisphere-specific tau pathology in Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-026-07898-z","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:17:37Z","timestamp":1780625857000},"page":"6195-6211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hemispheric lateralization of Tau associations with visual and verbal memory in Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6810-5920","authenticated-orcid":false,"given":"Jaime Fern\u00e1ndez","family":"Arias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Aumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Trudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Margherita-Poltronetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Bezgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Servaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Rahmouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kely","family":"Quispialaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ali","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kunach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Lu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevy","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Seungsu","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulantha S.","family":"Mathotaarachchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vitali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick","family":"Pascoal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Iturria-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Montembeault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"7898_CR1","doi-asserted-by":"publisher","unstructured":"Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC et al. 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The study was approved by the Montreal Neurological Institute PET working committee and the Douglas Mental Health University Institute Research Ethics Board.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained for all participants.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent to publish was included in the informed consent forms for participants, and all authors have also consented to publish.","order":4,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to disclose.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}