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Although dynamic 60-min acquisitions are established, shorter static imaging protocols are desirable for severely impaired patients. This study investigated the feasibility of short static time windows for [\n                      <jats:sup>18<\/jats:sup>\n                      F]F-DED PET imaging in AIE and MSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Dynamic 60-min [\n                      <jats:sup>18<\/jats:sup>\n                      F]F-DED PET scans were analyzed in 20 patients with AIE, 20 patients with MSA (MSA-P\/MSA-C), and 16 controls (CTRL). Disease-related lesions were manually segmented based on visually detectable positive PET-signal in AIE and MSA predilection sites (i.e. mesial temporal lobe, posterior putamen, cerebellar deep white matter), and standardized uptake value ratios (SUVr; cerebellar cortex as a reference tissue) were calculated for consecutive 10-min intervals. Advanced kinetic parameters (DVR, VTr) were derived using Logan plot and a one-tissue compartment model (1TC2k) with image-derived input functions, both applying the cerebellar cortex as a reference tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Static images acquired between 10 and 60\u00a0min p.i. showed good image contrast and signal-to-noise ratio. SUVr of lesions increased over time and approached a plateau at approximately 50\u201360\u00a0min p.i.. The strongest agreement between SUVr and DVR was observed between 30 and 50\u00a0min p.i.. Late-phase SUVr outperformed kinetic parameters in discriminating lesions from healthy tissue in both AIE and MSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Short static [\n                      <jats:sup>18<\/jats:sup>\n                      F\u2078 ]F-DED PET acquisitions are clinically robust for detecting neuroinflammation in AIE and MSA. A late static acquisition between 30\u201350\u00a0min p.i. provides the optimal balance between accuracy and scanning efficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-026-07932-0","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:35:25Z","timestamp":1779935725000},"page":"5709-5720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility of short imaging protocols for [18F]fluordeprenyl-D2 PET in autoimmune encephalitis and multiple system atrophy"],"prefix":"10.1007","volume":"53","author":[{"given":"Lisa","family":"Tagnin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia 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The study was conducted in accordance with the principles set out in the Helsinki Declaration.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"RAW has received speaker honoraria from and reports advisory board work for Novartis\/AAA. MB is a member of the Neuroimaging Committee of the EANM. MB has received speaker honoraria from Roche, GE Healthcare, Iba, Miltenyi, and Life Molecular Imaging; has advised Life Molecular Imaging, MIAC, Cenos, and GE healthcare; and is currently on the advisory or imaging review boards of AC Immune and ZRO Imaging. NK, AM, AS and GNB are full-time employees of Life Molecular Imaging, GmbH, Berlin, a Lantheus company. JAG received a research grant from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; SFB\/TRR 274, ID 408885537) and\n                      The Sumaira Foundation\n                      (SPARK Grant); received non-financial support from Merck, Novartis, Roche and speaker honoraria from WVAO eV and Kliniken Schmieder (Stiftung & Co.). TK has received personal fees for advisory boards from Alexion\/Astra Zeneca, UCB, Merck and Biogen and for speaker honoraria\/chairs and\/or lectures\/education from Alexion\/Astra Zeneca, Novartis Pharma, Roche Pharma, Horizon Therapeutics\/Amgen, Chugai Pharma. All other authors do not report conflicts of interest.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}