{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:47:05Z","timestamp":1785527225800,"version":"3.56.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100016003","name":"Istanbul University Cerrahpa\u015fa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016003","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n Differentiated thyroid cancer (DTC) is primarily evaluated using radioiodine (RAI) scanning; however, this approach is limited by the suboptimal imaging properties of\n 131<\/jats:sup>\n I, the cost and limited availability of\n 123<\/jats:sup>\n I, and restricted access to\n 124<\/jats:sup>\n I. [\n 18<\/jats:sup>\n F]Tetrafluoroborate (TFB), a PET radiotracer targeting the sodium\/iodide symporter, has emerged as a promising alternative. This prospective study assessed the diagnostic performance and biodistribution of TFB PET compared with\n 131<\/jats:sup>\n I scintigraphy in patients with DTC.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This prospective study enrolled 58 patients with histopathologically confirmed DTC after total or near-total thyroidectomy. Forty-eight patients underwent both TFB PET\/CT and\n 131<\/jats:sup>\n I SPECT scintigraphy, while 10 underwent only TFB PET for biodistribution analysis. Patients were stratified into preradioiodine (TFB before\n 131<\/jats:sup>\n I;\n n<\/jats:italic>\n \u2009=\u200928) and postradioiodine (TFB after\n 131<\/jats:sup>\n I;\n n<\/jats:italic>\n \u2009=\u200920) subgroups based on recent radioiodine administration (either diagnostic or therapeutic) to evaluate the potential stunning effect of\n 131<\/jats:sup>\n I on TFB uptake. Patient- and lesion-based analyses were performed, and agreement was assessed using Cohen\u2019s kappa.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In patient-based analysis, concordance between modalities showed both TFB and\n 131<\/jats:sup>\n I positivity in 20 patients, TFB-only positivity in 1 patient,\n 131<\/jats:sup>\n I-only positivity in 5 patients, and negativity in both modalities in 22 patients, yielding substantial overall agreement (\u03ba\u2009=\u20090.75). Agreement was almost perfect in the preradioiodine group (\u03ba\u2009=\u20090.84) but declined to a moderate level in the postradioiodine group (\u03ba\u2009=\u20090.49). In lesion-based analysis (\n n<\/jats:italic>\n \u2009=\u200956), overall detection rates were comparable (TFB, 85.7% vs.\n 131<\/jats:sup>\n I, 73.2%) but significantly higher for TFB in the preradioiodine group (95.7% vs. 68.1%,\n p<\/jats:italic>\n \u2009<\u20090.05). Lesion detection decreased markedly in the postradioiodine group (33.3%), consistent with a stunning effect. Biodistribution analysis showed highest physiological uptake in the stomach, salivary glands, esophagus, nasopharynx and unexpected uterine uptake in Nabothian cysts in 45% of female patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n TFB PET demonstrates diagnostic accuracy and lesion detection rates comparable to\n 131<\/jats:sup>\n I scintigraphy in DTC. Its diagnostic performance is superior in patients without recent radioiodine administration prior to TFB imaging, whereas lesion detectability decreases after radioiodine administration, likely due to a stunning effect. Therefore, TFB PET represents a promising alternative for disease burden assessment in DTC and warrants further multicenter validation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00259-026-07945-9","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:46:19Z","timestamp":1779777979000},"page":"5963-5970","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of [18F]Tetrafluoroborate PET versus 131I scintigraphy in differentiated thyroid cancer: a prospective study"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-5184","authenticated-orcid":false,"given":"Kerim","family":"Sonmezoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-8078","authenticated-orcid":false,"given":"Onur Erdem","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0626-5945","authenticated-orcid":false,"given":"Kerem","family":"Saglam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-2315","authenticated-orcid":false,"given":"Emre","family":"Karayel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Pehlivanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1868-3957","authenticated-orcid":false,"given":"Lebriz","family":"Uslu-Besli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-5707","authenticated-orcid":false,"given":"Haluk Burcak","family":"Sayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"7945_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. 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The study was approved by the Ethics Committee of Istanbul University-Cerrahpasa (Approval No: E-83045809-604.01.02-93530).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all participants.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors affirm that human research participants provided informed consent for publication of their data.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}