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We therefore aimed to compare both methods with regard to diagnostic accuracy within the same patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single centre study included all \u2265\u200950 year-old patients undergoing [\u00b9\u2078F]FDG PET\/CT between 2012 and 2023 for suspected new-onset GCA. Scans were re-read by two nuclear medicine physicians. Thirty-three arterial segments were scored visually, either with a standard criterion (activity at least equal liver, grade\u2009\u2265\u20092) or with a more specific one (activity above liver, grade 3). Standardized uptake values (SUVs) were measured in each segment, also normalized to liver and blood pool. For SUVs and ratios, ROC-curves were calculated per segment, segment groups and on the patient level to determine optimal cut-offs. The reference diagnosis was determined clinically by chart review after a follow-up of \u2265\u20096 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 163 patients, 39 (24%) with GCA, were included. Visual analysis with \u2265\u20091 segment with uptake grade\u2009\u2265\u20092 showed high sensitivity (80.0%, 95%-confidence interval (CI) 0.64\u20130.91) and specificity (83.0%, 95%-CI 0.75\u20130.89) and correct diagnosis in 82.0% (95%-CI 0.76\u20130.88). Using uptake grade 3, specificity was 96.0% (95%-CI 0.91\u20130.99) and sensitivity 59.0% (95%-CI 0.42\u20130.74), correct diagnosis in 87.0% (95%-CI 0.81\u20130.92). Semiquantitative methods proved less accurate, with SUVmax\/SUVmax(liver) ratio at a threshold of 0.917 having the highest accuracy (sensitivity 87.2%, specificity 58.9%, correct diagnosis 65.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In suspected, new-onset GCA, expert visual interpretation of [\u00b9\u2078F]FDG PET\/CT should be recommended, as it outperforms semiquantitative methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-026-07981-5","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:12:23Z","timestamp":1780729943000},"page":"6063-6074","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visual analysis of [18F]FDG PET\/CT imaging yields superior diagnostic accuracy compared to semiquantitative analysis in the assessment of giant cell arteritis"],"prefix":"10.1007","volume":"53","author":[{"given":"Luca","family":"Seitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahel","family":"Friedli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"G\u00f6zl\u00fcg\u00f6l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"L\u00f6tscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Gilgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Amsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"St\u00e4hli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Helfenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"D\u00f6ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgyi","family":"Hamvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schindewolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Rominger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Christ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-775X","authenticated-orcid":false,"given":"Federico","family":"Caobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"issue":"7","key":"7981_CR1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1007\/s00259-018-3973-8","volume":"45","author":"RHJA Slart","year":"2018","unstructured":"Slart RHJA, Writing group; Reviewer group; Members of EANM Cardiovascular. 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No biologic material was used in the present study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"LS, RF, SB, FL, PS and MG have nothing to disclose. Unrelated to this specific study, BM declares research grants from AbbVie, Protagen, and Novartis Biomedical Research; declares an mir-29 patent for the treatment of systemic sclerosis (US8247389, EP2331143); declares lecturing fees from Boehringer Ingelheim, GaxoSmithKline, Novartis, Otsuka, and Merck Sharpe & Dohme, Lilly; declares consulting fees from Novartis, Boehringer Ingelheim, Janssen-Cilag, and GaxoSmithKline; declares financial support for congresses (i.e., for registration fees and travel) from Medtalk, Pfizer, Roche, Actelion, Mepha, Boehringer Ingelheim, and Merck Sharpe & Dohme; and has been on an advisory board for Janssen and Boehringer. Axel Rominger and Federico Caobelli are Editors of this Journal. Federico Caobelli receives research grants from the Swiss National Science Foundation and Innosuisse and speaker Honoraria from Bracco AG, Blue Earth Diagnostics, Siemens and Pfizer for matters not related to the present work. No other potential conflicts of interest exist.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}