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This study aimed to develop an automated pipeline for standardised DS computation, evaluate the prognostic value of DS at five anatomical sites, and predict progression-free survival (PFS) by integrating DS with copy number alterations (CNA) and clinical variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort of 165 newly diagnosed MM patients with baseline FDG PET\/CT, CNA profiling, and blood tests was analysed. An automated pipeline computed DS fully automatically for vertebral bone marrow (BM) and long bones (LB), and semi-automatically for focal (FL), paramedullary (PM), and extramedullary (EM) lesions. DS were subdivided into absent (1), low (2\u20133), and high (4\u20135) groups and compared via log-rank test. A penalised Cox model with 12 covariates (five DS, three CNAs, haemoglobin, platelet count, age, sex) was evaluated via nested cross-validation for PFS prediction. For inference on individual prognostic contributions, an unpenalised multivariable Cox model was fitted on the full cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In univariate analyses, high LB, PM and EM DS were significantly associated with shorter PFS. The penalised Cox model achieved a C-index of 0.710 [95% CI: 0.689\u20130.732] in predicting the risk of progression. In the multivariable analysis, age, haemoglobin, BM DS, PM DS and amp(1q) were identified as independent prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Automated DS computation from baseline FDG PET\/CT is feasible and, combined with genomic and clinical data, enables a reproducible multimodal approach to prognostic stratification in MM. The pipeline for DS computation is publicly available as an open-source tool (autoDS-PET) at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/github.com\/Sara-Peluso\/autoDS-PET\" ext-link-type=\"uri\">https:\/\/github.com\/Sara-Peluso\/autoDS-PET<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00259-026-08103-x","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:44:14Z","timestamp":1785404654000},"page":"7336-7349","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Automated Deauville Score computation from baseline [\u00b9\u2078F]FDG PET\/CT predicts progression-free survival in multiple myeloma: a radiogenomic framework"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-1093","authenticated-orcid":false,"given":"Sara","family":"Peluso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-5156","authenticated-orcid":false,"given":"Stefano","family":"Polizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8081-1252","authenticated-orcid":false,"given":"Lisa","family":"Pagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-0542","authenticated-orcid":false,"given":"Martina","family":"Tarozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-2819","authenticated-orcid":false,"given":"Ettore","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0158-1708","authenticated-orcid":false,"given":"Valentino","family":"Dragonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-6955","authenticated-orcid":false,"given":"Vincenza","family":"Solli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-6870","authenticated-orcid":false,"given":"Daniele","family":"Dall\u2019Olio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3408-0461","authenticated-orcid":false,"given":"Marco","family":"Talarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-4785","authenticated-orcid":false,"given":"Carolina","family":"Terragna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-1047","authenticated-orcid":false,"given":"Claudia","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-7305","authenticated-orcid":false,"given":"Elena","family":"Zamagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-2624","authenticated-orcid":false,"given":"Stefano","family":"Fanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2000-1599","authenticated-orcid":false,"given":"Cristina","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-925X","authenticated-orcid":false,"given":"Gastone","family":"Castellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"8103_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. 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