{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:26:00Z","timestamp":1793676360288,"version":"4.5.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nucl Med Mol Imaging"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00259-026-08183-9","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:41:16Z","timestamp":1789540876000},"page":"8046-8060","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced \u00b9\u00b3N-Ammonia PET Myocardial Flow Reserve and Heart-Failure\u2013Related Risk Independent of Relative Ischemia in Chronic Coronary Syndrome"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-4914","authenticated-orcid":false,"given":"Yoshimitsu","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3618-7850","authenticated-orcid":false,"given":"Rika","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-7402","authenticated-orcid":false,"given":"Kenji","family":"Yodogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0081-5143","authenticated-orcid":false,"given":"Shiori","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-8430","authenticated-orcid":false,"given":"Shogo","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-4703","authenticated-orcid":false,"given":"Shinichiro","family":"Kumita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"8183_CR1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.jcmg.2010.04.007","volume":"3","author":"TH Schindler","year":"2010","unstructured":"Schindler TH, Schelbert HR, Quercioli A, Dilsizian V. Cardiac PET imaging for the detection and monitoring of coronary artery disease and microvascular health. JACC Cardiovasc Imaging. 2010;3:623\u201340. https:\/\/doi.org\/10.1016\/j.jcmg.2010.04.007.","journal-title":"JACC Cardiovasc Imaging"},{"key":"8183_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2967\/jnumed.117.201368","volume":"59","author":"VL Murthy","year":"2018","unstructured":"Murthy VL, Bateman TM, Beanlands RS, Berman DS, Borges-Neto S, Chareonthaitawee P, et al. Clinical quantification of myocardial blood flow using PET: joint position paper of the SNMMI Cardiovascular Council and the ASNC. J Nucl Med. 2018;59:273\u201393. https:\/\/doi.org\/10.2967\/jnumed.117.201368.","journal-title":"J Nucl Med"},{"key":"8183_CR3","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.jacc.2013.07.076","volume":"62","author":"KL Gould","year":"2013","unstructured":"Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, et al. Anatomic versus physiologic assessment of coronary artery disease. Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639\u201353. https:\/\/doi.org\/10.1016\/j.jacc.2013.07.076.","journal-title":"J Am Coll Cardiol"},{"key":"8183_CR4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1056\/NEJMra061889","volume":"356","author":"PG Camici","year":"2007","unstructured":"Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med. 2007;356:830\u201340. https:\/\/doi.org\/10.1056\/NEJMra061889.","journal-title":"N Engl J Med"},{"key":"8183_CR5","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","volume":"35","author":"F Crea","year":"2014","unstructured":"Crea F, Camici PG, Bairey Merz CN. Coronary microvascular dysfunction: an update. Eur Heart J. 2014;35:1101\u201311. https:\/\/doi.org\/10.1093\/eurheartj\/eht513.","journal-title":"Eur Heart J"},{"key":"8183_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijcard.2017.08.068","volume":"250","author":"P Ong","year":"2018","unstructured":"Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, et al. International standardization of diagnostic criteria for microvascular angina. Int J Cardiol. 2018;250:16\u201320. https:\/\/doi.org\/10.1016\/j.ijcard.2017.08.068.","journal-title":"Int J Cardiol"},{"key":"8183_CR7","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1161\/CIRCULATIONAHA.111.050427","volume":"124","author":"VL Murthy","year":"2011","unstructured":"Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Di Carli G, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124:2215\u201324. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.050427.","journal-title":"Circulation"},{"key":"8183_CR8","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.jacc.2011.01.065","volume":"58","author":"MC Ziadi","year":"2011","unstructured":"Ziadi MC, deKemp RA, Williams KA, Guo A, Chow BJW, Renaud JM, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol. 2011;58:740\u20138. https:\/\/doi.org\/10.1016\/j.jacc.2011.01.065.","journal-title":"J Am Coll Cardiol"},{"key":"8183_CR9","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2967\/jnumed.110.081828","volume":"52","author":"K Fukushima","year":"2011","unstructured":"Fukushima K, Javadi MS, Higuchi T, Lautam\u00e4ki R, Merrill J, Nekolla SG, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. J Nucl Med. 2011;52:726\u201332. https:\/\/doi.org\/10.2967\/jnumed.110.081828.","journal-title":"J Nucl Med"},{"key":"8183_CR10","doi-asserted-by":"publisher","first-page":"117280","DOI":"10.1016\/j.atherosclerosis.2023.117280","volume":"382","author":"AI Ahmed","year":"2023","unstructured":"Ahmed AI, Saad JM, Alahdab F, Han Y, Nayfeh M, Alfawara MS, et al. Prognostic value of positron emission tomography derived myocardial flow reserve: a systematic review and meta-analysis. Atherosclerosis. 2023;382:117280. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.117280.","journal-title":"Atherosclerosis"},{"key":"8183_CR11","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1093\/eurheartj\/ehab775","volume":"43","author":"MA Kelshiker","year":"2022","unstructured":"Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, et al. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. Eur Heart J. 2022;43:1582\u201393. https:\/\/doi.org\/10.1093\/eurheartj\/ehab775.","journal-title":"Eur Heart J"},{"key":"8183_CR12","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","volume":"41","author":"J Knuuti","year":"2020","unstructured":"Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41:407\u201377. https:\/\/doi.org\/10.1093\/eurheartj\/ehz425.","journal-title":"Eur Heart J"},{"key":"8183_CR13","doi-asserted-by":"publisher","first-page":"e368","DOI":"10.1161\/CIR.0000000000001029","volume":"144","author":"M Gulati","year":"2021","unstructured":"Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, et al. 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain. Circulation. 2021;144:e368\u2013454. https:\/\/doi.org\/10.1161\/CIR.0000000000001029.","journal-title":"Circulation"},{"key":"8183_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1161\/CIRCULATIONAHA.114.011939","volume":"131","author":"VR Taqueti","year":"2015","unstructured":"Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation. 2015;131:19\u201327. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.011939.","journal-title":"Circulation"},{"key":"8183_CR15","doi-asserted-by":"publisher","unstructured":"Gupta A, Taqueti VR, van de Hoef TP, Bajaj NS, Bravo PE, Murthy VL, et al. Integrated noninvasive physiological assessment of coronary circulatory function and impact on cardiovascular mortality in patients with stable coronary artery disease. Circulation. 2017;136:2325\u201336. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.029992.","DOI":"10.1161\/CIRCULATIONAHA.117.029992"},{"key":"8183_CR16","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1093\/eurheartj\/ehx721","volume":"39","author":"VR Taqueti","year":"2018","unstructured":"Taqueti VR, Solomon SD, Shah AM, Desai AS, Groarke JD, Osborne MT, et al. Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction. Eur Heart J. 2018;39:840\u20139. https:\/\/doi.org\/10.1093\/eurheartj\/ehx721.","journal-title":"Eur Heart J"},{"key":"8183_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.119.043916","volume":"141","author":"NS Bajaj","year":"2020","unstructured":"Bajaj NS, Singh A, Zhou W, Gupta A, Fujikura K, Byrne C, et al. Coronary microvascular dysfunction, left ventricular remodeling, and clinical outcomes in patients with chronic kidney impairment. Circulation. 2020;141:21\u201333. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.043916.","journal-title":"Circulation"},{"key":"8183_CR18","doi-asserted-by":"publisher","first-page":"e002562","DOI":"10.1161\/CIRCHEARTFAILURE.115.002562","volume":"9","author":"K Srivaratharajah","year":"2016","unstructured":"Srivaratharajah K, Coutinho T, deKemp R, Liu P, Haddad H, Stadnick E, et al. Reduced myocardial flow in heart failure patients with preserved ejection fraction. Circ Heart Fail. 2016;9:e002562. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.115.002562.","journal-title":"Circ Heart Fail"},{"key":"8183_CR19","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1161\/01.cir.88.1.62","volume":"88","author":"J Czernin","year":"1993","unstructured":"Czernin J, M\u00fcller P, Chan S, Brunken RC, Porenta G, Krivokapich J, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation. 1993;88:62\u20139. https:\/\/doi.org\/10.1161\/01.cir.88.1.62.","journal-title":"Circulation"},{"key":"8183_CR20","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s00259-020-05046-9","volume":"48","author":"R Sciagr\u00e0","year":"2021","unstructured":"Sciagr\u00e0 R, Lubberink M, Hyafil F, Saraste A, Slart RHJA, Agostini D, et al. EANM procedural guidelines for PET\/CT quantitative myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2021;48:1040\u201369. https:\/\/doi.org\/10.1007\/s00259-020-05046-9.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"8183_CR21","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/MNM.0000000000000293","volume":"36","author":"SG Cho","year":"2015","unstructured":"Cho SG, Kim JH, Cho JY, Kim HS, Kwon SY, Bom HS. Characteristics of anginal patients with high resting myocardial blood flow measured with N-13 ammonia PET\/CT. Nucl Med Commun. 2015;36:619\u201324. https:\/\/doi.org\/10.1097\/MNM.0000000000000293.","journal-title":"Nucl Med Commun"},{"key":"8183_CR22","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/eurheartj\/ehz389","volume":"41","author":"KK Patel","year":"2020","unstructured":"Patel KK, Spertus JA, Chan PS, Sperry BW, Al Badarin F, Kennedy KF, et al. Myocardial blood flow reserve assessed by positron emission tomography myocardial perfusion imaging identifies patients with a survival benefit from early revascularization. Eur Heart J. 2020;41:759\u201368. https:\/\/doi.org\/10.1093\/eurheartj\/ehz389.","journal-title":"Eur Heart J"},{"key":"8183_CR23","doi-asserted-by":"publisher","first-page":"e018729","DOI":"10.1161\/CIRCIMAGING.125.018729","volume":"19","author":"G Ramirez","year":"2026","unstructured":"Ramirez G, Builoff V, Miller RJH, Lemley M, Carvajal-Juarez I, Alexanderson E, et al. Multicenter evaluation of myocardial flow reserve as a prognostic marker for mortality in \u00b9\u00b3N-ammonia PET myocardial perfusion imaging. Circ Cardiovasc Imaging. 2026;19:e018729. https:\/\/doi.org\/10.1161\/CIRCIMAGING.125.018729.","journal-title":"Circ Cardiovasc Imaging"},{"key":"8183_CR24","doi-asserted-by":"publisher","first-page":"101854","DOI":"10.1016\/j.nuclcard.2024.101854","volume":"37","author":"DM Huck","year":"2024","unstructured":"Huck DM, Weber BN, Brown JM, Lopez D, Hainer J, Blankstein R, et al. Prognostic value of myocardial flow reserve vs corrected myocardial flow reserve in patients without obstructive coronary artery disease. J Nucl Cardiol. 2024;37:101854. https:\/\/doi.org\/10.1016\/j.nuclcard.2024.101854.","journal-title":"J Nucl Cardiol"},{"key":"8183_CR25","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1272\/jnms.JNMS.2023_90-213","volume":"90","author":"S Imai","year":"2023","unstructured":"Imai S, Kiriyama T, Kanaya K, Aoyama S, Takano H, Kumita S. Estimation of microvascular dysfunction by using \u00b9\u00b3N-ammonia positron emission tomography with quantitative myocardial blood flow analysis in chronic coronary syndrome. J Nippon Med Sch. 2023;90:228\u201336. https:\/\/doi.org\/10.1272\/jnms.JNMS.2023_90-213.","journal-title":"J Nippon Med Sch"},{"key":"8183_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12350-015-0074-y","volume":"23","author":"M Suda","year":"2016","unstructured":"Suda M, Onoguchi M, Tomiyama T, Ishihara K, Takahashi N, Sakurai M, et al. The reproducibility of time-of-flight PET and conventional PET for the quantification of myocardial blood flow and coronary flow reserve with \u00b9\u00b3N-ammonia. J Nucl Cardiol. 2016;23:457\u201372. https:\/\/doi.org\/10.1007\/s12350-015-0074-y.","journal-title":"J Nucl Cardiol"},{"key":"8183_CR27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","volume":"40","author":"K Thygesen","year":"2019","unstructured":"Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40:237\u201369. https:\/\/doi.org\/10.1093\/eurheartj\/ehy462.","journal-title":"Eur Heart J"},{"key":"8183_CR28","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","volume":"42","author":"TA McDonagh","year":"2021","unstructured":"McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, B\u00f6hm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599\u2013726. https:\/\/doi.org\/10.1093\/eurheartj\/ehab368.","journal-title":"Eur Heart J"},{"key":"8183_CR29","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","volume":"43","author":"K Zeppenfeld","year":"2022","unstructured":"Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022;43:3997\u20134126. https:\/\/doi.org\/10.1093\/eurheartj\/ehac262.","journal-title":"Eur Heart J"},{"key":"8183_CR30","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s12350-010-9255-x","volume":"17","author":"HR Schelbert","year":"2010","unstructured":"Schelbert HR. Anatomy and physiology of coronary blood flow. J Nucl Cardiol. 2010;17:545\u201354. https:\/\/doi.org\/10.1007\/s12350-010-9255-x.","journal-title":"J Nucl Cardiol"},{"key":"8183_CR31","doi-asserted-by":"publisher","first-page":"102222","DOI":"10.1016\/j.nuclcard.2025.102222","volume":"49","author":"M Al Rifai","year":"2025","unstructured":"Al Rifai M, Ahmed AI, Nayfeh M, Nabi F, Al-Mallah MH. The prognostic significance of rate pressure product corrected myocardial flow reserve. J Nucl Cardiol. 2025;49:102222. https:\/\/doi.org\/10.1016\/j.nuclcard.2025.102222.","journal-title":"J Nucl Cardiol"},{"key":"8183_CR32","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00259-021-05459-0","volume":"49","author":"E von Felten","year":"2021","unstructured":"von Felten E, Benz DC, Benetos G, Baehler J, Patriki D, Rampidis GP, et al. Prognostic value of regional myocardial flow reserve derived from \u00b9\u00b3N-ammonia positron emission tomography in patients with suspected coronary artery disease. Eur J Nucl Med Mol Imaging. 2021;49:311\u201320. https:\/\/doi.org\/10.1007\/s00259-021-05459-0.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"8183_CR33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jacc.2009.02.069","volume":"54","author":"BA Herzog","year":"2009","unstructured":"Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, et al. Long-term prognostic value of \u00b9\u00b3N-ammonia myocardial perfusion positron emission tomography: added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150\u20136. https:\/\/doi.org\/10.1016\/j.jacc.2009.02.069.","journal-title":"J Am Coll Cardiol"},{"key":"8183_CR34","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.2967\/jnumed.114.145342","volume":"55","author":"VL Murthy","year":"2014","unstructured":"Murthy VL, Lee BC, Sitek A, Naya M, Moody J, Polavarapu V, et al. Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with 82Rb PET. J Nucl Med. 2014;55:1952\u20138. https:\/\/doi.org\/10.2967\/jnumed.114.145342.","journal-title":"J Nucl Med"},{"key":"8183_CR35","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/ehjci\/jez258","volume":"21","author":"MJ Bom","year":"2020","unstructured":"Bom MJ, van Diemen PA, Driessen RS, Everaars H, Schumacher SP, Wijmenga JT, et al. Prognostic value of [15O]H2O positron emission tomography-derived global and regional myocardial perfusion. Eur Heart J Cardiovasc Imaging. 2020;21:777\u201386. https:\/\/doi.org\/10.1093\/ehjci\/jez258.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"8183_CR36","doi-asserted-by":"publisher","first-page":"e015184","DOI":"10.1161\/CIRCIMAGING.122.015184","volume":"16","author":"S H\u00f8jstrup","year":"2023","unstructured":"H\u00f8jstrup S, Hansen KW, Talleruphuus U, Marner L, Bjerking L, Jakobsen L, et al. Myocardial flow reserve, an independent prognostic marker of all-cause mortality assessed by \u2078\u00b2Rb PET myocardial perfusion imaging: a Danish multicenter study. Circ Cardiovasc Imaging. 2023;16:e015184. https:\/\/doi.org\/10.1161\/CIRCIMAGING.122.015184.","journal-title":"Circ Cardiovasc Imaging"},{"key":"8183_CR37","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.jcmg.2012.06.007","volume":"5","author":"VL Murthy","year":"2012","unstructured":"Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Dorbala S, et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging. 2012;5:1025\u201334. https:\/\/doi.org\/10.1016\/j.jcmg.2012.06.007.","journal-title":"JACC Cardiovasc Imaging"},{"key":"8183_CR38","doi-asserted-by":"publisher","first-page":"214","DOI":"10.2967\/jnumed.108.054395","volume":"50","author":"RA Tio","year":"2009","unstructured":"Tio RA, Dabeshlim A, Siebelink HM, de Sutter J, Hillege HL, Zeebregts CJ, et al. Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease. J Nucl Med. 2009;50:214\u20139. https:\/\/doi.org\/10.2967\/jnumed.108.054395.","journal-title":"J Nucl Med"},{"key":"8183_CR39","doi-asserted-by":"publisher","first-page":"248","DOI":"10.2967\/jnumed.113.121442","volume":"55","author":"M Naya","year":"2014","unstructured":"Naya M, Murthy VL, Taqueti VR, Foster CR, Klein J, Garber M, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med. 2014;55:248\u201355. https:\/\/doi.org\/10.2967\/jnumed.113.121442.","journal-title":"J Nucl Med"},{"key":"8183_CR40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1161\/CIRCULATIONAHA.116.023266","volume":"135","author":"VR Taqueti","year":"2017","unstructured":"Taqueti VR, Shaw LJ, Cook NR, Murthy VL, Shah NR, Foster CR, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with severely impaired coronary flow reserve, not obstructive disease. Circulation. 2017;135:566\u201377. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.023266.","journal-title":"Circulation"},{"key":"8183_CR41","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1093\/ehjci\/jeaf132","volume":"26","author":"A Sayed","year":"2025","unstructured":"Sayed A, Al Rifai M, Alwan M, Al-Mallah MH. The prognostic interplay between PET-derived resting myocardial blood flow and left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. 2025;26:1333\u201342. https:\/\/doi.org\/10.1093\/ehjci\/jeaf132.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"8183_CR42","doi-asserted-by":"publisher","first-page":"qyae115","DOI":"10.1093\/ehjimp\/qyae115","volume":"2","author":"A Roby","year":"2024","unstructured":"Roby A, Harmon L, Sander K, Bui L, Kitkungvan D, Patel M, et al. Reproducibility of quantitative myocardial perfusion and coronary flow capacity by positron emission tomography: 3D digital silicon photomultiplier solid state vs. legacy 2D analogue systems for clinical practice and trials. Eur Heart J Imaging Methods Pract. 2024;2:qyae115. https:\/\/doi.org\/10.1093\/ehjimp\/qyae115.","journal-title":"Eur Heart J Imaging Methods Pract"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-026-08183-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-026-08183-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00259-026-08183-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:29:55Z","timestamp":1793672995000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00259-026-08183-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":42,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["8183"],"URL":"https:\/\/doi.org\/10.1007\/s00259-026-08183-9","relation":{},"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"14 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. It was approved by the Central Ethics Committee of Nippon Medical School (approval number M-2026-559).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Because of the retrospective design using de-identified data, the requirement for written informed consent was waived by the ethics committee, and an opt-out information sheet was posted in accordance with Japanese national guidelines.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. The illustrative case images (Fig.\u00a0\n                      \n                      ) are fully de-identified and contain no information that could identify individual patients.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}