{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:13Z","timestamp":1786979893158,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s00261-016-0713-z","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T17:26:26Z","timestamp":1459358786000},"page":"1596-1603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Testis ultrasound in Klinefelter syndrome infertile men: making the diagnosis and avoiding inappropriate management"],"prefix":"10.1007","volume":"41","author":[{"given":"Laurence","family":"Rocher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Correas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mutuon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Ferlicot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Izard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Brailly-Tabard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie France","family":"Bellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"713_CR1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jcem-2-11-615","volume":"2","author":"H Klinefelter","year":"1942","unstructured":"Klinefelter H, Rifenstein E, Albright F (1942) Syndrome characterized by gynecomastia, aspermatogenesis without A leydigism and excretion of follicle stimulating hormone. J Clin Endocrinol Metab 2:615\u2013627","journal-title":"J Clin Endocrinol Metab"},{"key":"713_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0140-6736(04)16678-6","volume":"364","author":"F Lanfranco","year":"2004","unstructured":"Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E (2004) Klinefelter\u2019s syndrome. Lancet 364:273\u2013283. doi: 10.1016\/S0140-6736(04)16678-6","journal-title":"Lancet"},{"key":"713_CR3","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/EJE-12-0934","volume":"168","author":"L Aksglaede","year":"2013","unstructured":"Aksglaede L, Juul A (2013) Testicular function and fertility in men with Klinefelter syndrome: a review. Eur J Endocrinol 168:R67\u2013R76. doi: 10.1530\/EJE-12-0934","journal-title":"Eur J Endocrinol"},{"key":"713_CR4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1023\/A:1020959818687","volume":"19","author":"E Ekerhovd","year":"2002","unstructured":"Ekerhovd E, Westlander G (2002) Testicular sonography in men with Klinefelter syndrome shows irregular echogenicity and blood flow of high resistance. J Assist Reprod Genet 19:517\u2013522","journal-title":"J Assist Reprod Genet"},{"key":"713_CR5","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0015-0282(01)01793-9","volume":"75","author":"G Westlander","year":"2001","unstructured":"Westlander G, Ekerhovd E, Granberg S, et al. (2001) Testicular ultrasonography and extended chromosome analysis in men with nonmosaic Klinefelter syndrome: a prospective study of possible predictive factors for successful sperm recovery. Fertil Steril 75:1102\u20131105","journal-title":"Fertil Steril"},{"key":"713_CR6","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.purol.2014.08.003","volume":"24","author":"A Rock","year":"2014","unstructured":"Rock A, Marcelli F, Robin G, et al. (2014) Clinical and paraclinical features of Klinefelter syndrome consulting for male infertility. Progres Urol. 24:757\u2013763. doi: 10.1016\/j.purol.2014.08.003","journal-title":"Progres Urol."},{"key":"713_CR7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.4103\/1008-682X.128514","volume":"17","author":"G Accardo","year":"2015","unstructured":"Accardo G, Vallone G, Esposito D, et al. (2015) Testicular parenchymal abnormalities in Klinefelter syndrome: a question of cancer? Examination of 40 consecutive patients. Asian J Androl 17:154\u2013158. doi: 10.4103\/1008-682X.128514","journal-title":"Asian J Androl"},{"key":"713_CR8","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1007\/s00330-012-2520-4","volume":"22","author":"J Richenberg","year":"2012","unstructured":"Richenberg J, Brejt N (2012) Testicular microlithiasis: is there a need for surveillance in the absence of other risk factors? Eur Radiol 22:2540\u20132546. doi: 10.1007\/s00330-012-2520-4","journal-title":"Eur Radiol"},{"key":"713_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.beem.2010.08.006","volume":"25","author":"C Krausz","year":"2011","unstructured":"Krausz C (2011) Male infertility: pathogenesis and clinical diagnosis. Best Pract Res Clin Endocrinol Metab 25:271\u2013285. doi: 10.1016\/j.beem.2010.08.006","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"713_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/humupd\/dmu042","volume":"21","author":"F Lotti","year":"2015","unstructured":"Lotti F, Maggi M (2015) Ultrasound of the male genital tract in relation to male reproductive health. Hum Reprod Update 21:56\u201383. doi: 10.1093\/humupd\/dmu042","journal-title":"Hum Reprod Update"},{"key":"713_CR11","unstructured":"Jungwirth A, Diemer T, Dohle G.R, et al. (2014) Guidelines on male infertility. http:\/\/uroweb.org\/wp-content\/uploads\/EAU-Guidelines-Male-Infertility-20151.pdf"},{"key":"713_CR12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.juro.2008.03.021","volume":"180","author":"JB Eifler Jr","year":"2008","unstructured":"Eifler JB Jr, King P, Schlegel PN (2008) Incidental testicular lesions found during infertility evaluation are usually benign and may be managed conservatively. J Urol 180:261\u2013264 (discussion 265). doi: 10.1016\/j.juro.2008.03.021","journal-title":"J Urol"},{"key":"713_CR13","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/j.juro.2009.12.012","volume":"183","author":"PJ Toren","year":"2010","unstructured":"Toren PJ, Roberts M, Lecker I, et al. (2010) Small incidentally discovered testicular masses in infertile men\u2013is active surveillance the new standard of care? J Urol 183:1373\u20131377. doi: 10.1016\/j.juro.2009.12.012","journal-title":"J Urol"},{"key":"713_CR14","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1097\/01.ju.0000092066.01699.90","volume":"170","author":"L Carmignani","year":"2003","unstructured":"Carmignani L, Gadda F, Gazzano G, et al. (2003) High incidence of benign testicular neoplasms diagnosed by ultrasound. J Urol 170:1783\u20131786. doi: 10.1097\/01.ju.0000092066.01699.90","journal-title":"J Urol"},{"key":"713_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/aja.2011.57","volume":"14","author":"GR Dohle","year":"2012","unstructured":"Dohle GR, Elzanaty S, van Casteren NJ (2012) Testicular biopsy: clinical practice and interpretation. Asian J Androl 14:88\u201393. doi: 10.1038\/aja.2011.57","journal-title":"Asian J Androl"},{"key":"713_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-209805","author":"J Sterbis","year":"2015","unstructured":"Sterbis J, Toritsetimiyin E (2015) Leydig cell hyperplasia in the setting of Klinefelter syndrome. BMJ Case Rep. doi: 10.1136\/bcr-2015-209805","journal-title":"BMJ Case Rep"},{"key":"713_CR17","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/j.1651-2227.2011.02280.x","volume":"100","author":"N Lahlou","year":"2011","unstructured":"Lahlou N, Fennoy I, Ross JL, et al. (2011) Clinical and hormonal status of infants with nonmosaic XXY karyotype. Acta Paediatr Oslo Nor 1992 100:824\u2013829. doi: 10.1111\/j.1651-2227.2011.02280.x","journal-title":"Acta Paediatr Oslo Nor 1992"},{"key":"713_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1159\/000117387","volume":"69","author":"AM Wikstr\u00f6m","year":"2008","unstructured":"Wikstr\u00f6m AM, Dunkel L (2008) Testicular function in Klinefelter syndrome. Horm Res 69:317\u2013326. doi: 10.1159\/000117387","journal-title":"Horm Res"},{"key":"713_CR19","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1111\/j.1651-2227.2011.02246.x","volume":"100","author":"L Aksglaede","year":"2011","unstructured":"Aksglaede L, Skakkebaek NE, Almstrup K, Juul A (2011) Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience. Acta Paediatr Oslo Nor 1992 100:793\u2013806. doi: 10.1111\/j.1651-2227.2011.02246.x","journal-title":"Acta Paediatr Oslo Nor 1992"},{"key":"713_CR20","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/path.1309","volume":"199","author":"M Holm","year":"2003","unstructured":"Holm M, Rajpert-De Meyts E, Andersson A-M, Skakkebaek NE (2003) Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone\/LH ratio. J Pathol 199:378\u2013386. doi: 10.1002\/path.1309","journal-title":"J Pathol"},{"key":"713_CR21","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1093\/humrep\/deu124","volume":"29","author":"G Lottrup","year":"2014","unstructured":"Lottrup G, Nielsen JE, Maroun LL, et al. (2014) Expression patterns of DLK1 and INSL3 identify stages of Leydig cell differentiation during normal development and in testicular pathologies, including testicular cancer and Klinefelter syndrome. Hum Reprod Oxf Engl 29:1637\u20131650. doi: 10.1093\/humrep\/deu124","journal-title":"Hum Reprod Oxf Engl"},{"key":"713_CR22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ando.2014.03.007","volume":"75","author":"E Nieschlag","year":"2014","unstructured":"Nieschlag E, Werler S, Wistuba J, Zitzmann M (2014) New approaches to the Klinefelter syndrome. Ann Endocrinol 75:88\u201397. doi: 10.1016\/j.ando.2014.03.007","journal-title":"Ann Endocrinol"},{"key":"713_CR23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<363::AID-PD79>3.0.CO;2-O","volume":"17","author":"L Abramsky","year":"1997","unstructured":"Abramsky L, Chapple J (1997) 47, XXY (Klinefelter syndrome) and 47, XYY: estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling. Prenat Diagn 17:363\u2013368","journal-title":"Prenat Diagn"},{"key":"713_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.purol.2011.08.030","volume":"22","author":"C Butruille","year":"2012","unstructured":"Butruille C, Marcelli F, Ghoneim T, et al. (2012) Management of testicular lesions in a population of infertile patients. Prog En Urol J Assoc Fr Urol Soci\u00e9t\u00e9 Fr Urol 22:45\u201352. doi: 10.1016\/j.purol.2011.08.030","journal-title":"Prog En Urol J Assoc Fr Urol Soci\u00e9t\u00e9 Fr Urol"},{"key":"713_CR25","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1111\/j.1464-410X.2011.10177.x","volume":"108","author":"N Leonhartsberger","year":"2011","unstructured":"Leonhartsberger N, Ramoner R, Aigner F, et al. (2011) Increased incidence of Leydig cell tumours of the testis in the era of improved imaging techniques. BJU Int 108:1603\u20131607. doi: 10.1111\/j.1464-410X.2011.10177.x","journal-title":"BJU Int"},{"key":"713_CR26","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.fertnstert.2013.12.051","volume":"101","author":"MK Samplaski","year":"2014","unstructured":"Samplaski MK, Lo KC, Grober ED, et al. (2014) Phenotypic differences in mosaic Klinefelter patients as compared with non-mosaic Klinefelter patients. Fertil Steril 101:950\u2013955. doi: 10.1016\/j.fertnstert.2013.12.051","journal-title":"Fertil Steril"},{"key":"713_CR27","first-page":"44","volume":"11","author":"V Sanctis De","year":"2013","unstructured":"De Sanctis V, Fiscina B, Soliman A, et al. (2013) Klinefelter syndrome and cancer: from childhood to adulthood. Pediatr Endocrinol Rev 11:44\u201350","journal-title":"Pediatr Endocrinol Rev"},{"key":"713_CR28","first-page":"1471","volume":"36","author":"M Tada","year":"1990","unstructured":"Tada M, Takimoto Y, Kishimoto T (1990) Immature teratoma of the testis associated with Klinefelter\u2019s syndrome: a case report. Hinyokika Kiyo 36:1471\u20131474","journal-title":"Hinyokika Kiyo"},{"key":"713_CR29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1442-2042.2006.01331.x","volume":"13","author":"T Yoshida","year":"2006","unstructured":"Yoshida T, Takao T, Tsujimura A, et al. (2006) Testicular epidermoid cyst in Klinefelter\u2019s syndrome. Int J Urol 13:478\u2013480. doi: 10.1111\/j.1442-2042.2006.01331.x","journal-title":"Int J Urol"},{"key":"713_CR30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00007611-199106000-00026","volume":"84","author":"SR Reddy","year":"1991","unstructured":"Reddy SR, Svec F, Richardson P (1991) Seminoma of the testis in a patient with 48, XXYY variant of Klinefelter\u2019s syndrome. South Med J 84:773\u2013775","journal-title":"South Med J"},{"key":"713_CR31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/bjc.1995.85","volume":"71","author":"H Hasle","year":"1995","unstructured":"Hasle H, Mellemgaard A, Nielsen J, Hansen J (1995) Cancer incidence in men with Klinefelter syndrome. Br J Cancer 71:416\u2013420","journal-title":"Br J Cancer"},{"key":"713_CR32","first-page":"4491","volume":"19","author":"JC Soria","year":"1999","unstructured":"Soria JC, Durdux C, Chr\u00e9tien Y, et al. (1999) Malignant Leydig cell tumor of the testis associated with Klinefelter\u2019s syndrome. Anticancer Res 19:4491\u20134494","journal-title":"Anticancer Res"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-016-0713-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00261-016-0713-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-016-0713-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:18:19Z","timestamp":1558700299000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00261-016-0713-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,30]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["713"],"URL":"https:\/\/doi.org\/10.1007\/s00261-016-0713-z","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734554793.793555157","asserted-by":"object"}]},"ISSN":["2366-004X","2366-0058"],"issn-type":[{"value":"2366-004X","type":"print"},{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,30]]}}}