{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:16:34Z","timestamp":1792782994019,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T00:00:00Z","timestamp":1563580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T00:00:00Z","timestamp":1563580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Special scientific research projects of Beijing science and technology project","award":["Z16110000051610"],"award-info":[{"award-number":["Z16110000051610"]}]},{"name":"Beijing hope marathon special fund","award":["LC2016A05"],"award-info":[{"award-number":["LC2016A05"]}]},{"name":"Peking Union Medical College Youth Fund, the Fundamental Research Funds for the Central Universities","award":["3332018078"],"award-info":[{"award-number":["3332018078"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Beijing Hope Run Special Fund of the Cancer Foundation of China","award":["LC2017B18"],"award-info":[{"award-number":["LC2017B18"]}],"id":[{"id":"https:\/\/ror.org\/03qendm16","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s00261-019-02129-6","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T02:02:23Z","timestamp":1563588143000},"page":"2978-2987","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Developing a prediction model based on MRI for pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer"],"prefix":"10.1007","volume":"44","author":[{"given":"Lijuan","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongda","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangmei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,20]]},"reference":[{"issue":"16","key":"2129_CR1","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1200\/JCO.2011.40.1836","volume":"30","author":"R Sauer","year":"2012","unstructured":"Sauer R, Liersch T, Merkel S, et al. (2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO\/ARO\/AIO-94 randomized phase III trial after a median follow-up of 11 years. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 30(16):1926\u20131933. \n                    https:\/\/doi.org\/10.1200\/jco.2011.40.1836","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"9","key":"2129_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","volume":"11","author":"M Maas","year":"2010","unstructured":"Maas M, Nelemans PJ, Valentini V, et al. (2010) Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. The Lancet Oncology 11(9):835\u2013844. \n                    https:\/\/doi.org\/10.1016\/s1470-2045(10)70172-8","journal-title":"The Lancet Oncology"},{"issue":"12","key":"2129_CR3","doi-asserted-by":"publisher","first-page":"4303","DOI":"10.1007\/s00330-016-4283-9","volume":"26","author":"AM Hotker","year":"2016","unstructured":"Hotker AM, Tarlinton L, Mazaheri Y, et al. (2016) Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemoradiotherapy: A comparison of morphological, volumetric and functional MRI parameters. European Radiology 26(12):4303\u20134312. \n                    https:\/\/doi.org\/10.1007\/s00330-016-4283-9","journal-title":"European Radiology"},{"issue":"2","key":"2129_CR4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","volume":"17","author":"AG Renehan","year":"2016","unstructured":"Renehan AG, Malcomson L, Emsley R, et al. (2016) Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis. The Lancet Oncology 17(2):174\u2013183. \n                    https:\/\/doi.org\/10.1016\/s1470-2045(15)00467-2","journal-title":"The Lancet Oncology"},{"issue":"4","key":"2129_CR5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s11605-011-1459-0","volume":"15","author":"CA Sartori","year":"2011","unstructured":"Sartori CA, Sartori A, Vigna S, Occhipinti R, Baiocchi GL (2011) Urinary and sexual disorders after laparoscopic TME for rectal cancer in males. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 15(4):637\u2013643. \n                    https:\/\/doi.org\/10.1007\/s11605-011-1459-0","journal-title":"Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract"},{"issue":"4","key":"2129_CR6","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.ijrobp.2010.07.007","volume":"81","author":"M Braendengen","year":"2011","unstructured":"Braendengen M, Tveit KM, Bruheim K, et al. (2011) Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized Phase III study. International journal of radiation oncology, biology, physics 81(4):1017\u20131024. \n                    https:\/\/doi.org\/10.1016\/j.ijrobp.2010.07.007","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"2129_CR7","doi-asserted-by":"publisher","first-page":"e600","DOI":"10.5114\/pjr.2018.81156","volume":"83","author":"N Tarallo","year":"2018","unstructured":"Tarallo N, Angeretti MG, Bracchi E, et al. (2018) Magnetic resonance imaging in locally advanced rectal cancer: quantitative evaluation of the complete response to neoadjuvant therapy. Polish journal of radiology 83:e600\u2013e609. \n                    https:\/\/doi.org\/10.5114\/pjr.2018.81156","journal-title":"Polish journal of radiology"},{"issue":"1","key":"2129_CR8","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00330-012-2578-z","volume":"23","author":"E Kluza","year":"2013","unstructured":"Kluza E, Rozeboom ED, Maas M, et al. (2013) T2 weighted signal intensity evolution may predict pathological complete response after treatment for rectal cancer. European radiology 23(1):253\u2013261. \n                    https:\/\/doi.org\/10.1007\/s00330-012-2578-z","journal-title":"European radiology"},{"issue":"1","key":"2129_CR9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1148\/radiol.2018171804","volume":"288","author":"NE Enkhbaatar","year":"2018","unstructured":"Enkhbaatar NE, Inoue S, Yamamuro H, et al. (2018) MR Imaging with Apparent Diffusion Coefficient Histogram Analysis: Evaluation of Locally Advanced Rectal Cancer after Chemotherapy and Radiation Therapy. Radiology 288(1):129\u2013137. \n                    https:\/\/doi.org\/10.1148\/radiol.2018171804","journal-title":"Radiology"},{"issue":"1","key":"2129_CR10","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/s13063-017-2085-2","volume":"18","author":"NJ Battersby","year":"2017","unstructured":"Battersby NJ, Dattani M, Rao S, et al. (2017) A rectal cancer feasibility study with an embedded phase III trial design assessing magnetic resonance tumour regression grade (mrTRG) as a novel biomarker to stratify management by good and poor response to chemoradiotherapy (TRIGGER): study protocol for a randomised controlled trial. Trials 18(1):394. \n                    https:\/\/doi.org\/10.1186\/s13063-017-2085-2","journal-title":"Trials"},{"issue":"1","key":"2129_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13244-019-0706-x","volume":"10","author":"DMJ Lambregts","year":"2019","unstructured":"Lambregts DMJ, Boellaard TN, Beets-Tan RGH (2019) Response evaluation after neoadjuvant treatment for rectal cancer using modern MR imaging: a pictorial review. Insights into imaging 10(1):15. \n                    https:\/\/doi.org\/10.1186\/s13244-019-0706-x","journal-title":"Insights into imaging"},{"issue":"3","key":"2129_CR12","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.ijrobp.2004.11.005","volume":"62","author":"YH Kim","year":"2005","unstructured":"Kim YH, Kim DY, Kim TH, et al. (2005) Usefulness of magnetic resonance volumetric evaluation in predicting response to preoperative concurrent chemoradiotherapy in patients with resectable rectal cancer. International journal of radiation oncology, biology, physics 62(3):761\u2013768. \n                    https:\/\/doi.org\/10.1016\/j.ijrobp.2004.11.005","journal-title":"International journal of radiation oncology, biology, physics"},{"issue":"2","key":"2129_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11888-018-0398-5","volume":"14","author":"L Bernier","year":"2018","unstructured":"Bernier L, Balyasnikova S, Tait D, Brown G (2018) Watch-and-Wait as a Therapeutic Strategy in Rectal Cancer. Current colorectal cancer reports 14(2):37\u201355. \n                    https:\/\/doi.org\/10.1007\/s11888-018-0398-5","journal-title":"Current colorectal cancer reports"},{"issue":"10","key":"2129_CR14","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1038\/bjc.2017.320","volume":"117","author":"F Sclafani","year":"2017","unstructured":"Sclafani F, Brown G, Cunningham D, et al. (2017) Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer. Br J Cancer 117(10):1478\u20131485. \n                    https:\/\/doi.org\/10.1038\/bjc.2017.320","journal-title":"Br J Cancer"},{"issue":"1","key":"2129_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1148\/radiol.2017162657","volume":"285","author":"SH Park","year":"2017","unstructured":"Park SH, Lim JS, Lee J, et al. (2017) Rectal Mucinous Adenocarcinoma: MR Imaging Assessment of Response to Concurrent Chemotherapy and Radiation Therapy-A Hypothesis-generating Study. Radiology 285(1):124\u2013133. \n                    https:\/\/doi.org\/10.1148\/radiol.2017162657","journal-title":"Radiology"},{"key":"2129_CR16","doi-asserted-by":"crossref","unstructured":"Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet (London, England) 2 (8514):996-999","DOI":"10.1016\/S0140-6736(86)92612-7"},{"issue":"2","key":"2129_CR17","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/bjs.5917","volume":"95","author":"NJ Smith","year":"2008","unstructured":"Smith NJ, Barbachano Y, Norman AR, et al. (2008) Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. The British journal of surgery 95(2):229\u2013236. \n                    https:\/\/doi.org\/10.1002\/bjs.5917","journal-title":"The British journal of surgery"},{"issue":"28","key":"2129_CR18","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1200\/JCO.2011.34.9068","volume":"29","author":"UB Patel","year":"2011","unstructured":"Patel UB, Taylor F, Blomqvist L, et al. (2011) Magnetic resonance imaging-detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCURY experience. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 29(28):3753\u20133760. \n                    https:\/\/doi.org\/10.1200\/jco.2011.34.9068","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"12","key":"2129_CR19","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.ejrad.2015.08.008","volume":"84","author":"E Neri","year":"2015","unstructured":"Neri E, Guidi E, Pancrazi F, et al. (2015) MRI tumor volume reduction rate vs tumor regression grade in the pre-operative re-staging of locally advanced rectal cancer after chemo-radiotherapy. European journal of radiology 84(12):2438\u20132443. \n                    https:\/\/doi.org\/10.1016\/j.ejrad.2015.08.008","journal-title":"European journal of radiology"},{"issue":"2","key":"2129_CR20","doi-asserted-by":"publisher","first-page":"e193","DOI":"10.1016\/j.ijrobp.2011.03.022","volume":"82","author":"SG Yeo","year":"2012","unstructured":"Yeo SG, Kim DY, Park JW, et al. (2012) Tumor volume reduction rate after preoperative chemoradiotherapy as a prognostic factor in locally advanced rectal cancer. International journal of radiation oncology, biology, physics 82(2):e193\u2013199. \n                    https:\/\/doi.org\/10.1016\/j.ijrobp.2011.03.022","journal-title":"International journal of radiation oncology, biology, physics"},{"issue":"1051","key":"2129_CR21","doi-asserted-by":"publisher","first-page":"20150097","DOI":"10.1259\/bjr.20150097","volume":"88","author":"T Seierstad","year":"2015","unstructured":"Seierstad T, Hole KH, Groholt KK, et al. (2015) MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer. The British journal of radiology 88(1051):20150097. \n                    https:\/\/doi.org\/10.1259\/bjr.20150097","journal-title":"The British journal of radiology"},{"issue":"9","key":"2129_CR22","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.crad.2016.05.005","volume":"71","author":"MR Siddiqui","year":"2016","unstructured":"Siddiqui MR, Gormly KL, Bhoday J, et al. (2016) Interobserver agreement of radiologists assessing the response of rectal cancers to preoperative chemoradiation using the MRI tumour regression grading (mrTRG). Clinical radiology 71(9):854\u2013862. \n                    https:\/\/doi.org\/10.1016\/j.crad.2016.05.005","journal-title":"Clinical radiology"},{"issue":"4","key":"2129_CR23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1200\/JGO.2015.001479","volume":"2","author":"MS Fayaz","year":"2016","unstructured":"Fayaz MS, Demian GA, Fathallah WM, et al. (2016) Significance of Magnetic Resonance Imaging-Assessed Tumor Response for Locally Advanced Rectal Cancer Treated With Preoperative Long-Course Chemoradiation. Journal of global oncology 2(4):216\u2013221. \n                    https:\/\/doi.org\/10.1200\/jgo.2015.001479","journal-title":"Journal of global oncology"},{"issue":"3","key":"2129_CR24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.ijrobp.2013.06.2052","volume":"87","author":"SK Yu","year":"2013","unstructured":"Yu SK, Tait D, Chau I, Brown G (2013) MRI predictive factors for tumor response in rectal cancer following neoadjuvant chemoradiation therapy\u2013implications for induction chemotherapy? International journal of radiation oncology, biology, physics 87(3):505\u2013511. \n                    https:\/\/doi.org\/10.1016\/j.ijrobp.2013.06.2052","journal-title":"International journal of radiation oncology, biology, physics"},{"issue":"3","key":"2129_CR25","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00384-013-1821-7","volume":"29","author":"ML Garland","year":"2014","unstructured":"Garland ML, Vather R, Bunkley N, Pearse M, Bissett IP (2014) Clinical tumour size and nodal status predict pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancer. International journal of colorectal disease 29(3):301\u2013307. \n                    https:\/\/doi.org\/10.1007\/s00384-013-1821-7","journal-title":"International journal of colorectal disease"},{"issue":"7","key":"2129_CR26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/DCR.0b013e31828e5a72","volume":"56","author":"U Wallin","year":"2013","unstructured":"Wallin U, Rothenberger D, Lowry A, Luepker R, Mellgren A (2013) CEA - a predictor for pathologic complete response after neoadjuvant therapy for rectal cancer. Diseases of the colon and rectum 56(7):859\u2013868. \n                    https:\/\/doi.org\/10.1097\/DCR.0b013e31828e5a72","journal-title":"Diseases of the colon and rectum"},{"issue":"6","key":"2129_CR27","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1097\/DCR.0b013e3182837e5b","volume":"56","author":"JW Huh","year":"2013","unstructured":"Huh JW, Kim HR, Kim YJ (2013) Clinical prediction of pathological complete response after preoperative chemoradiotherapy for rectal cancer. Diseases of the colon and rectum 56(6):698\u2013703. \n                    https:\/\/doi.org\/10.1097\/DCR.0b013e3182837e5b","journal-title":"Diseases of the colon and rectum"},{"issue":"4","key":"2129_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.clcc.2015.06.001","volume":"14","author":"D Armstrong","year":"2015","unstructured":"Armstrong D, Raissouni S, Price Hiller J, et al. (2015) Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study. Clinical colorectal cancer 14(4):291\u2013295. \n                    https:\/\/doi.org\/10.1016\/j.clcc.2015.06.001","journal-title":"Clinical colorectal cancer"},{"key":"2129_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1748-717X-8-43","volume":"8","author":"KL Yang","year":"2013","unstructured":"Yang KL, Yang SH, Liang WY, et al. (2013) Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery. Radiation oncology (London, England) 8:43. \n                    https:\/\/doi.org\/10.1186\/1748-717x-8-43","journal-title":"Radiation oncology (London, England)"},{"issue":"12","key":"2129_CR30","doi-asserted-by":"publisher","first-page":"5231","DOI":"10.1007\/s00330-018-5520-1","volume":"28","author":"S Kim","year":"2018","unstructured":"Kim S, Han K, Seo N, et al. (2018) T2-weighted signal intensity-selected volumetry for prediction of pathological complete response after preoperative chemoradiotherapy in locally advanced rectal cancer. European radiology 28(12):5231\u20135240. \n                    https:\/\/doi.org\/10.1007\/s00330-018-5520-1","journal-title":"European radiology"},{"issue":"23","key":"2129_CR31","doi-asserted-by":"publisher","first-page":"7253","DOI":"10.1158\/1078-0432.CCR-17-1038","volume":"23","author":"Z Liu","year":"2017","unstructured":"Liu Z, Zhang XY, Shi YJ, et al. (2017) Radiomics Analysis for Evaluation of Pathological Complete Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer. Clinical cancer research: an official journal of the American Association for Cancer Research 23(23):7253\u20137262. \n                    https:\/\/doi.org\/10.1158\/1078-0432.ccr-17-1038","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"3","key":"2129_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1159\/000485511","volume":"94","author":"G Saito","year":"2018","unstructured":"Saito G, Sadahiro S, Ogimi T, et al. (2018) Relations of Changes in Serum Carcinoembryonic Antigen Levels before and after Neoadjuvant Chemoradiotherapy and after Surgery to Histologic Response and Outcomes in Patients with Locally Advanced Rectal Cancer. Oncology 94(3):167\u2013175. \n                    https:\/\/doi.org\/10.1159\/000485511","journal-title":"Oncology"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-019-02129-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00261-019-02129-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-019-02129-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T19:03:42Z","timestamp":1595099022000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00261-019-02129-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,20]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["2129"],"URL":"https:\/\/doi.org\/10.1007\/s00261-019-02129-6","relation":{},"ISSN":["2366-004X","2366-0058"],"issn-type":[{"value":"2366-004X","type":"print"},{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,20]]},"assertion":[{"value":"20 July 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}