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To evaluate intra-procedural splanchnic circulation changes, post-processing of digital subtraction angiography (DSA) series was performed. Regions of interest (ROIs) were placed in the superior mesenteric artery (SMA; reference), the portal vein (PV; ROI<jats:sub>PV<\/jats:sub>), as well as the aorta next to the origin of the SMA (ROI<jats:sub>Aorta<\/jats:sub>). Peak density (PD), time to peak (TTP), and area under the curve (AUC) were assessed, and parametric ratios \u2018target ROI<jats:sub>PD, TTP, AUC<\/jats:sub>\/reference ROI\u2019 were computed and compared within treatment and control group. Additionally, a NOMI score was assessed pre- and post-treatment compared to 2D-PA.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Vasodilator therapy leads to a significant decrease of the 2D-PA-derived values PD<jats:sub>Aorta<\/jats:sub> (<jats:italic>p\u2009<\/jats:italic>=\u20090.04) and AUC<jats:sub>Aorta<\/jats:sub> (<jats:italic>p\u2009<\/jats:italic>=\u20090.03). These findings correlated with changes of the simplified NOMI score, both for overall (4 to 1, <jats:italic>p\u2009<\/jats:italic>&lt;\u20090.0001) and for each category. Prostaglandin application caused a significant increase of the AUC<jats:sub>PV<\/jats:sub> (<jats:italic>p\u2009<\/jats:italic>=\u20090.04) and TTP<jats:sub>PV<\/jats:sub> was accelerated without reaching statistical significance (<jats:italic>p\u2009<\/jats:italic>=\u20090.13). When compared to a control group, all 2D-PA values in the NOMI group (pre- and post-intervention) differed significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) with longer TTP<jats:sub>Aorta\/PV<\/jats:sub> and lower AUC<jats:sub>Aorta\/PV<\/jats:sub> and PD <jats:sub>Aorta\/PV<\/jats:sub>.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>2D-PA offers an objective approach to analyze immediate flow and perfusion changes following vasodilatory therapies of NOMI patients and may be a valuable tool for assessing treatment response.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00261-020-02457-y","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T06:02:57Z","timestamp":1582696977000},"page":"3342-3351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Non-occlusive mesenteric ischemia (NOMI): evaluation of 2D-perfusion angiography (2D-PA) for early treatment response assessment"],"prefix":"10.1007","volume":"45","author":[{"given":"Lena S.","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo C.","family":"Meine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"von Falck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard C.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia L. 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The remaining authors declare no relationships with any companies whose products or services may be related to the subject matter of the article. All authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}