{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:01:33Z","timestamp":1754485293495},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To perform a radiologic-pathologic correlation analysis of sigmoid colon in patients undergoing pre-operative CT Colonography (CTC) after an episode of acute diverticulitis (AD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty-nine consecutive patients (31\/28\u00a0M\/F; 58\u2009\u00b1\u200913\u00a0years) underwent CTC 55\u2009\u00b1\u200918\u00a0days after AD, 8\u2009\u00b1\u20094\u00a0weeks before surgery. Thirty-seven patients (63%) underwent conventional abdominal CT at time of AD. An experienced blinded radiologist retrospectively analyzed all images: disease severity was graded according to the Ambrosetti classification on conventional CT and according to the diverticular disease severity score (DDSS) on CTC. A GI pathologist performed a dedicated analysis, evaluating the presence of acute and chronic inflammation, and fibrosis, using 0\u20133 point scale for each variable.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 59 patients, 41 (69%) had at least one previous AD episode; twenty-six patients (44%) had a complicated AD. DDSS was mild-moderate in 34\/59 (58%), and severe in 25\/59 (42%). All patients had chronic inflammation, while 90% had low-to-severe fibrosis. Patients with moderate\/severe fibrosis were older than those with no\/mild fibrosis (61\u2009\u00b1\u200913 versus 54\u2009\u00b1\u200913). We found a significant correlation between DDSS and chronic inflammation (<jats:italic>p\u2009<\/jats:italic>=\u20090.004), as well as DDSS and fibrosis (<jats:italic>p\u2009<\/jats:italic>=\u20090.005). Furthermore, fibrosis was correlated with complicated acute diverticulitis (<jats:italic>p\u2009<\/jats:italic>=\u20090.0.27), and with age (<jats:italic>p\u2009<\/jats:italic>=\u20090.067). At multivariate analysis, complicated diverticulitis was the best predictor of fibrosis (odds ratio 4.4). Patient age and DDSS were other independent predictors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>DDSS-based assessment on preoperative CTC was a good predictor of chronic colonic inflammation and fibrosis. In addition, the presence of complicated diverticulitis on CT during the acute episode was most predictive of fibrosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00261-020-02690-5","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T11:06:04Z","timestamp":1596452764000},"page":"491-497","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CT colonography followed by elective surgery in patients with acute diverticulitis: a radiological-pathological correlation study"],"prefix":"10.1007","volume":"46","author":[{"given":"Nicola","family":"Flor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry J.","family":"Pickhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Maconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Panella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Falleni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"2690_CR1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.gastrohep.2015.03.010","volume":"38","author":"CJ Gargallo Puyuelo","year":"2015","unstructured":"Gargallo Puyuelo CJ, Sope\u00f1a F, Lanas Arbeloa A (2015) Colonic diverticular disease. 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