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Patients enrolled in an institutional AILD registry were divided into groups: (1) autoimmune hepatitis (AIH) or (2) primary sclerosing cholangitis (PSC)\/autoimmune sclerosing cholangitis (ASC). Participants underwent serum liver biochemistry testing and research MRI examinations, including 3D magnetic resonance cholangiopancreatography (MRCP), magnetic resonance elastography (MRE), and iron-corrected T1 mapping (cT1). MRCP\u2009+\u2009and LiverMultiScan (Perspectum Ltd., Oxford, UK) were used to post-process 3D MRCP and cT1 data. Multiple linear regression models were used to assess relationships.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>58 patients, 35 male, median age 16\u00a0years were included; 30 in the AIH group, 28 in the PSC\/ASC group. After statistical adjustments for patient age, sex, presence of inflammatory bowel disease (IBD), specific diagnosis (PSC\/ASC vs. AIH), and time from diagnosis to MRI examination, left hepatic bile duct maximum diameter was a statistically significant predictor of whole liver mean cT1, cT1 interquartile range (IQR), and MRE liver stiffness (<jats:italic>p<\/jats:italic>\u2009=\u20090.01\u20130.04). Seven laboratory values were significant predictors of whole liver cT1 IQR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001\u20130.04). Eight laboratory values and right hepatic bile duct median and maximum diameter were significant predictors of liver stiffness (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001\u20130.03).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Bile duct diameters and multiple laboratory biomarkers of liver disease are independent predictors of liver stiffness and cT1 IQR in pediatric patients with AILD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00261-021-03378-0","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T14:04:51Z","timestamp":1640095491000},"page":"672-683","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Associations between MRI T1 mapping, liver stiffness, quantitative MRCP, and laboratory biomarkers in children and young adults with autoimmune liver disease"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-3811","authenticated-orcid":false,"given":"Neeraja","family":"Mahalingam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Trout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deep B.","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi D.","family":"Sahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Miethke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Dillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"3378_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02595-3","author":"N Abu Ata","year":"2020","unstructured":"Abu Ata N, Dillman JR, Gandhi DB, Dudley JA, Trout AT, Miethke AG (2020) Association between liver diffusion-weighted imaging apparent diffusion coefficient values and other measures of liver disease in pediatric autoimmune liver disease patients. 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(Oxford, United Kingdom) provided in-kind support in the form of image post-processing for this study. Drs. Jonathan R. Dillman and Andrew T. Trout have received grant support from Perspectum Ltd, Siemens Medical Solutions, and Canon Medical Systems. Dr. Dillman has also received in-kind research support from Resoundant, Inc. and Philips Healthcare. No other authors have conflicts of interest to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in a manner compliant with the Health Insurance Portability and Accountability Act (HIPAA, USA) and was approved by the institutional review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants, and informed assent was obtained as appropriate.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}