{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:19:36Z","timestamp":1791908376978,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00261-022-03557-7","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T12:09:48Z","timestamp":1654603788000},"page":"2325-2334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Determining the efficacy of functional liver imaging score (FLIS) obtained from gadoxetic acid-enhanced MRI in patients with chronic liver disease and liver cirrhosis: the relationship between Albumin-Bilirubin (ALBI) grade and FLIS"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-8767","authenticated-orcid":false,"given":"Serdar","family":"Aslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-621X","authenticated-orcid":false,"given":"Uluhan","family":"Eryuruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-8135","authenticated-orcid":false,"given":"Merve Nur","family":"Tasdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-7493","authenticated-orcid":false,"given":"Ismet Mirac","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"3557_CR1","unstructured":"Kochanek KD, Murphy SL (2016) National Vital Statistic Report 65"},{"key":"3557_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"ZM Younossi","year":"2016","unstructured":"Younossi ZM, Koenig AB, Abdelatif D, et al. (2016) Global epidemiology of nonalcoholic fatty liver disease\u2014 meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64:73\u201384. https:\/\/ doi: https:\/\/doi.org\/10.1002\/hep.28431.","journal-title":"Hepatology"},{"key":"3557_CR3","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1016\/j.cgh.2015.07.029","volume":"13","author":"A Ahmed","year":"2015","unstructured":"Ahmed A, Wong RJ, Harrison SA (2015) Nonalcoholic fatty liver disease review: diagnosis, treatment, and outcomes. Clin Gastroenterol Hepatol 13:2062\u20132070. https:\/\/ doi: https:\/\/doi.org\/10.1016\/j.cgh.2015.07.029.","journal-title":"Clin Gastroenterol Hepatol."},{"key":"3557_CR4","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","volume":"58","author":"M Blachier","year":"2013","unstructured":"Blachier M, Leleu H, Peck-Radosavljevic M, et al. (2013) The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol 58:593\u2013608. https:\/\/ doi: https:\/\/doi.org\/10.1016\/j.jhep.2012.12.005.","journal-title":"J Hepatol"},{"key":"3557_CR5","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/jmri.25518","volume":"45","author":"A Ba-Ssalamah","year":"2017","unstructured":"Ba-Ssalamah A, Bastati N, Wibmer A, et al. (2017) Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: where are we? J Magn Reson Imaging 45:646\u2013659. https:\/\/ doi: https:\/\/doi.org\/10.1002\/jmri.25518.","journal-title":"J Magn Reson Imaging"},{"key":"3557_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000452846","volume":"6","author":"A Hiraoka","year":"2017","unstructured":"Hiraoka A, Kumada T, Kudo M, et al. (2017) Albumin-Bilirubin (ALBI) Grade as Part of the Evidence-Based Clinical Practice Guideline for HCC of the Japan Society of Hepatology: A Comparison with the Liver Damage and Child-Pugh Classifications. Liver Cancer 6:204-215. https:\/\/ doi: https:\/\/doi.org\/10.1159\/000452846.","journal-title":"Liver Cancer"},{"key":"3557_CR7","doi-asserted-by":"publisher","first-page":"8606","DOI":"10.1007\/s00330-021-07955-1","volume":"31","author":"HJ Lee","year":"2021","unstructured":"Lee HJ, Hong SB, Lee NK, et al. (2021) Validation of functional liver imaging scores (FLIS) derived from gadoxetic acid-enhanced MRI in patients with chronic liver disease and liver cirrhosis: the relationship between Child-Pugh score and FLIS. Eur Radiol 31:8606-8614. https:\/\/ doi: https:\/\/doi.org\/10.1007\/s00330-021-07955-1.","journal-title":"Eur Radiol"},{"key":"3557_CR8","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1148\/radiol.11100586","volume":"260","author":"A Yamada","year":"2011","unstructured":"Yamada A, Hara T, Li F, et al. (2011) Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology 260:727\u2013733. https:\/\/ doi: https:\/\/doi.org\/10.1148\/radiol.11100586.","journal-title":"Radiology"},{"key":"3557_CR9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1148\/radiol.13130210","volume":"269","author":"A Wibmer","year":"2013","unstructured":"Wibmer A, Prusa AM, Nolz R, et al. (2013) Liver failure after major liver resection: risk assessment by using preoperative gadoxetic acid-enhanced 3-T MR imaging. Radiology 269:777\u2013786. https:\/\/ doi: https:\/\/doi.org\/10.1148\/radiol.13130210.","journal-title":"Radiology"},{"key":"3557_CR10","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00330-014-3108-y","volume":"24","author":"N Verloh","year":"2014","unstructured":"Verloh N, Haimerl M, Zeman F, et al. (2014) Assessing liver function by liver enhancement during the hepatobiliary phase with Gd- EOB-DTPA-enhanced MRI at 3 Tesla. Eur Radiol 24:1013\u20131019. https:\/\/ doi: https:\/\/doi.org\/10.1007\/s00330-014-3108-y.","journal-title":"Eur Radiol"},{"key":"3557_CR11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1148\/radiol.2018180753","volume":"290","author":"JH Yoon","year":"2018","unstructured":"Yoon JH, Lee JM, Kang HJ, et al. (2018) Quantitative assessment of liver function by using gadoxetic acid\u2013enhanced MRI: hepatocyte uptake ratio. Radiology 290:125-133. https:\/\/ doi: https:\/\/doi.org\/10.1148\/radiol.2018180753.","journal-title":"Radiology"},{"key":"3557_CR12","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1148\/radiol.12110337","volume":"263","author":"S Sourbron","year":"2012","unstructured":"Sourbron S, Sommer WH, Reiser MF, et al. (2012) Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging. Radiology 263:874\u2013883. https:\/\/ doi: https:\/\/doi.org\/10.1148\/radiol.12110337.","journal-title":"Radiology"},{"key":"3557_CR13","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/RLI.0000000000000286","volume":"51","author":"N Bastati","year":"2016","unstructured":"Bastati N, Wibmer A, Tamandl D, et al. (2016) Assessment of Orthotopic Liver Transplant Graft Survival on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging Using Qualitative and Quantitative Parameters. Invest Radiol 51:728\u2013734. https:\/\/ doi: https:\/\/doi.org\/10.1097\/RLI.0000000000000286.","journal-title":"Invest Radiol"},{"key":"3557_CR14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1148\/radiol.2019190734","volume":"294","author":"N Bastati","year":"2020","unstructured":"Bastati N, Beer L, Mandorfer M, et al. (2020). Does the Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predict Outcomes in Chronic Liver Disease? Radiology 294:98-107. https:\/\/ doi: https:\/\/doi.org\/10.1148\/radiol.2019190734.","journal-title":"Radiology"},{"key":"3557_CR15","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","volume":"33","author":"PJ Johnson","year":"2015","unstructured":"Johnson PJ, Berhane S, Kagebayashi C, et al. (2015) Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol 33: 550\u2013558. https:\/\/ doi: https:\/\/doi.org\/10.1200\/JCO.2014.57.9151.","journal-title":"J Clin Oncol"},{"key":"3557_CR16","doi-asserted-by":"publisher","first-page":"9078","DOI":"10.1038\/s41598-018-27401-5","volume":"8","author":"M Haimerl","year":"2018","unstructured":"Haimerl M, Probst U, Poelsterl S, et al. (2018) Hepatobiliary MRI: signal intensity based assessment of liver function correlated to 13C-methacetin breath test. Sci Rep 8:9078. https:\/\/ doi: https:\/\/doi.org\/10.1038\/s41598-018-27401-5.","journal-title":"Sci Rep"},{"key":"3557_CR17","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1016\/j.ejrad.2016.10.010","volume":"85","author":"Y Takatsu","year":"2016","unstructured":"Takatsu Y, Kobayashi S, Miyati T, et al. (2016) Hepatobiliary phase images using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced MRI as an imaging surrogate for the albumin\u2013bilirubin grading system. Eur J Radiol 85:2206\u20132210. https:\/\/ doi: https:\/\/doi.org\/10.1016\/j.ejrad.2016.10.010.","journal-title":"Eur J Radiol"},{"key":"3557_CR18","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1007\/s00330-018-5366-6","volume":"28","author":"K Sandrasegaran","year":"2018","unstructured":"Sandrasegaran K, Cui E, Elkady R, et al. (2018) Can functional parameters from hepatobiliary phase of gadoxetate MRI predict clinical outcomes in patients with cirrhosis? Eur Radiol 28:4215-4224. https:\/\/ doi: https:\/\/doi.org\/10.1007\/s00330-018-5366-6.","journal-title":"Eur Radiol"},{"key":"3557_CR19","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.5754\/hge13291","volume":"60","author":"H Okubo","year":"2013","unstructured":"Okubo H, Mogami M, Ozaki Y, et al. (2013) Liver function test by gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging with consideration of intrahepatic regional differences. Hepatogastroenterology 60: 1547\u20131551. https:\/\/ doi: https:\/\/doi.org\/10.5754\/hge13291.","journal-title":"Hepatogastroenterology"},{"key":"3557_CR20","doi-asserted-by":"publisher","first-page":"6600","DOI":"10.1007\/s00330-019-06182-z","volume":"29","author":"L Beer","year":"2019","unstructured":"Beer L, Mandorfer M, Bastati N, et al. (2019) Inter- and intra-reader agreement for gadoxetic acid enhanced MRI parameter readings in patients with chronic liver diseases. Eur Radiol 29:6600-6610. https:\/\/ doi: https:\/\/doi.org\/10.1007\/s00330-019-06182-z.","journal-title":"Eur Radiol"},{"key":"3557_CR21","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00428-011-1099-5","volume":"459","author":"F Vasuri","year":"2011","unstructured":"Vasuri F, Golfieri R, Fiorentino M, et al. (2011) OATP 1B1\/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation. Virchows Arch 459:141\u2013146. https:\/\/ doi: https:\/\/doi.org\/10.1007\/s00428-011-1099-5.","journal-title":"Virchows Arch"},{"key":"3557_CR22","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/jmri.21956","volume":"30","author":"U Motosugi","year":"2009","unstructured":"Motosugi U, Ichikawa T, Sou H, et al. (2009) Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging 30:1042\u20131046. https:\/\/ doi: https:\/\/doi.org\/10.1002\/jmri.21956.","journal-title":"J Magn Reson Imaging"},{"key":"3557_CR23","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/jmri.23700","volume":"36","author":"NK Lee","year":"2012","unstructured":"Lee NK, Kim S, Kim GH, et al. (2012) Significance of the \u201cdelayed hyperintense portal vein sign\u201d in the hepatobiliary phase MRI obtained with Gd-EOB-DTPA. J Magn Reson Imaging 36:678\u2013685. https:\/\/ doi: https:\/\/doi.org\/10.1002\/jmri.23700.","journal-title":"J Magn Reson Imaging"},{"key":"3557_CR24","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1111\/jgh.12938","volume":"30","author":"AW Chan","year":"2015","unstructured":"Chan AW, Chan RC, Wong GL, et al. (2015) New simple prognostic score for primary biliary cirrhosis: albumin-bilirubin score. J Gastroenterol Hepatol 30:1391\u20131396. https:\/\/ doi: https:\/\/doi.org\/10.1111\/jgh.12938.","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-022-03557-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-022-03557-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-022-03557-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:04:53Z","timestamp":1655942693000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-022-03557-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["3557"],"URL":"https:\/\/doi.org\/10.1007\/s00261-022-03557-7","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"assertion":[{"value":"17 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Due to its retrospective design, we waived the requirement for informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Yes.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This prospective study was approved by Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all patients participating in the study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}