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MRE feasibility and diagnostic performance between patients with normal and elevated LIC were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with elevated LIC (21%) had significantly higher MRE failure rates (24.1% vs. 3.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to patients with normal LIC (79%). For those with only insignificant to mild iron overload (LIC\u2009&lt;\u20095.4 mg\/g; 17%), MRE failure rate did not differ significantly from patients without iron overload (8.3% vs. 3.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.315). R2* predicted MRE failure with fair accuracy at a threshold of R2*\u2009\u2265\u2009269 s<jats:sup>\u22121<\/jats:sup> (LIC of approximately 4.6 mg\/g). MRE showed good diagnostic performance for detecting significant (\u2265\u2009F2) and severe fibrosis (\u2265\u2009F3) in patients without (AUC 0.835 and 0.900) and with iron overload (AUC 0.818 and 0.889) without significant difference between the cohorts (<jats:italic>p<\/jats:italic>\u2009=\u20090.884 and <jats:italic>p<\/jats:italic>\u2009=\u20090.913). For detecting cirrhosis MRE showed an excellent diagnostic performance in both groups (AUC 0.944 and 1.000, <jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Spin-echo EPI MRE at 3 Tesla is feasible in patients with mild iron overload with good to excellent performance for detecting hepatic fibrosis with a failure rate comparable to patients without iron overload.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00261-023-04160-0","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T08:01:59Z","timestamp":1720684919000},"page":"3871-3882","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility and performance of spin-echo EPI MR elastography at 3 Tesla for staging hepatic fibrosis in the presence of hepatic iron overload"],"prefix":"10.1007","volume":"49","author":[{"given":"David","family":"Sgier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"J\u00fcngst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Renzulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Biletska-Hanchorova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Kannengiesser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Gubler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-192X","authenticated-orcid":false,"given":"Caecilia S.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"issue":"7","key":"4160_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1056\/NEJM200102153440706","volume":"344","author":"AA Bravo","year":"2001","unstructured":"Bravo AA, Sheth SG, Chopra S. 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All other authors declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Institutional Review Board approval was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Some study subjects or cohorts have been previously reported in S. von Ulmenstein, S. Bogdanovic, H. Honcharova-Biletska, S. Bl\u00fcmel, A.R. Deibel, D. Segna, C. J\u00fcngst, A. Weber, T. Kuntzen, C. Gubler, C.S. 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