{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:22:04Z","timestamp":1789690924562,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Scientific Foundation Committee of China","award":["82172027"],"award-info":[{"award-number":["82172027"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"DOI":"10.1007\/s00261-024-04253-4","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T19:01:53Z","timestamp":1715713313000},"page":"3427-3437","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study"],"prefix":"10.1007","volume":"49","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jundong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiChun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuilian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erpeng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiQiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-2334","authenticated-orcid":false,"given":"Xiaoling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"4253_CR1","doi-asserted-by":"crossref","unstructured":"Sung H, Ferlay J, Siegel RL, et al. \"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries\" in CA: A Cancer Journal for Clinicians, 2021, 71(3): 209-249.","DOI":"10.3322\/caac.21660"},{"key":"4253_CR2","unstructured":"\"Guidelines for the Diagnosis and Treatment of Primary Liver Cancer\" in Chinese Journal of Practical Surgery, 2022, 42(03):241-273."},{"issue":"19","key":"4253_CR3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015445","volume":"98","author":"HB Guo","year":"2019","unstructured":"Guo HB, Wang JH. \"Impact of Contrast Ultrasound Diagnosis for Patients with Liver Cancer\" in Medicine (Baltimore), 2019 May;98(19):e15445.","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"4253_CR4","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1055\/a-1177-0530","volume":"41","author":"CF Dietrich","year":"2020","unstructured":"Dietrich CF, Nols\u00f8e CP, Barr RG, et al. \"Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver - Update 2020 - WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS\" in Ultraschall Med, 2020 Oct;41(5):562-585.","journal-title":"Ultraschall Med"},{"issue":"1","key":"4253_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1055\/s-0042-124369","volume":"38","author":"Y Kono","year":"2017","unstructured":"Kono Y, Lyshchik A, Cosgrove D, et al. \"Contrast Enhanced Ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS(R)): The Official Version by the American College of Radiology (ACR)\" in Ultraschall Med, 2017, 38(1): 85-86.","journal-title":"Ultraschall Med"},{"issue":"1","key":"4253_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.2214\/AJR.19.21739","volume":"214","author":"M Lin","year":"2020","unstructured":"Lin M, Lu DS, Duan Y, et al. \"Cirrhotic Nodule Transformation to Hepatocellular Carcinoma: Natural History and Predictive Biomarkers on Contrast-Enhanced Ultrasound\" in AJR Am J Roentgenol, 2020 Jan; 214(1):96-104.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"4253_CR7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.hpb.2019.08.012","volume":"22","author":"M Okuno","year":"2020","unstructured":"Okuno M, Newhook TE, Joechle K, et al. \"Characteristics of Atypical Large Well-Differentiated Hepatocellular Carcinoma: A Specific Subtype of Hepatocellular Carcinoma?\" in HPB (Oxford), 2020 Apr;22(4):545-552.","journal-title":"HPB (Oxford)"},{"issue":"3","key":"4253_CR8","doi-asserted-by":"publisher","first-page":"191","DOI":"10.14366\/usg.20057","volume":"39","author":"JY Lee","year":"2020","unstructured":"Lee JY, Minami Y, Choi BI, et al. \"The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid\" in Ultrasonography, 2020 Jul;39(3):191-220.","journal-title":"Ultrasonography"},{"issue":"4","key":"4253_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","volume":"11","author":"M Omata","year":"2017","unstructured":"Omata M, Cheng AL, Kokudo N, et al. \"Asia-Pacific Clinical Practice Guidelines on the Management of Hepatocellular Carcinoma: A 2017 Update\" in Hepatology International, 2017 Jul;11(4):317-370.","journal-title":"Hepatology International"},{"issue":"4","key":"4253_CR10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","volume":"48","author":"P Lambin","year":"2012","unstructured":"Lambin P, Rios-Velazquez E, Leijenaar R, et al. \"Radiomics: Extracting More Information from Medical Images Using Advanced Feature Analysis\" in European Journal of Cancer, 2012 Mar;48(4):441-6.","journal-title":"European Journal of Cancer"},{"issue":"5","key":"4253_CR11","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.ultrasmedbio.2016.12.016","volume":"43","author":"Q Zhang","year":"2017","unstructured":"Zhang Q, Xiao Y, Suo J, et al. Sonoelastomics for Breast Tumor Classification: A Radiomics Approach with Clustering-Based Feature Selection on Sonoelastography. Ultrasound Med Biol. 2017 May;43(5):1058-1069.","journal-title":"Ultrasound Med Biol."},{"issue":"1","key":"4253_CR12","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1186\/s12885-018-5003-4","volume":"18","author":"Z Yao","year":"2018","unstructured":"Yao Z, Dong Y, Wu G, et al. Preoperative diagnosis and prediction of hepatocellular carcinoma: Radiomics analysis based on multi-modal ultrasound images. BMC Cancer. 2018 Nov 12;18(1):1089","journal-title":"BMC Cancer."},{"issue":"4","key":"4253_CR13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1159\/000505694","volume":"9","author":"F Liu","year":"2020","unstructured":"Liu F, Liu D, Wang K, et al. Deep Learning Radiomics Based on Contrast-Enhanced Ultrasound Might Optimize Curative Treatments for Very-Early or Early-Stage Hepatocellular Carcinoma Patients. Liver Cancer. 2020 Aug;9(4):397-413.","journal-title":"Liver Cancer."},{"key":"4253_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2022.101352","volume":"18","author":"Z Chuanji","year":"2022","unstructured":"Chuanji Z, Zheng W, Shaolv L, et al. Comparative study of radiomics, tumor morphology, and clinicopathological factors in predicting overall survival of patients with rectal cancer before surgery. Transl Oncol. 2022 Apr;18:101352","journal-title":"Transl Oncol."},{"key":"4253_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7594","volume":"350","author":"GS Collins","year":"2015","unstructured":"Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ. 2015 Jan 7;350:g7594","journal-title":"BMJ."},{"issue":"1","key":"4253_CR16","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s00330-019-06347-w","volume":"30","author":"FZ Mokrane","year":"2020","unstructured":"Mokrane FZ, Lu L, Vavasseur A, et al. Radiomics machine learning signature for diagnosis of hepatocellular carcinoma in cirrhotic patients with indeterminate liver nodules[J]. Eur Radiol, 2020, 30(1): 558-70.","journal-title":"Eur Radiol"},{"issue":"35","key":"4253_CR17","doi-asserted-by":"publisher","first-page":"5978","DOI":"10.3748\/wjg.v27.i35.5978","volume":"27","author":"R Stollmayer","year":"2021","unstructured":"Stollmayer R, Budai BK, T\u00f3th A, et al. Diagnosis of focal liver lesions with deep learning-based multi-channel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging[J]. World J Gastroenterol, 2021, 27(35): 5978-88.","journal-title":"World J Gastroenterol"},{"issue":"5","key":"4253_CR18","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1007\/s00330-017-5152-x","volume":"28","author":"M Wu","year":"2018","unstructured":"Wu M, Li L, Wang J, et al. Contrast-enhanced US for characterization of focal liver lesions: a comprehensive meta-analysis. Eur Radiol. 2018 May;28(5):2077-2088.","journal-title":"Eur Radiol."},{"issue":"9","key":"4253_CR19","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1002\/jcu.22499","volume":"45","author":"WY Yang","year":"2017","unstructured":"Yang WY, Park HS, Kim YJ, et al. Visibility of focal liver lesions: Comparison between Kupffer phase of CEUS with Sonazoid and hepatobiliary phase of gadoxetic acid-enhanced MRI. J Clin Ultrasound. 2017 Nov 12;45(9):542-550.","journal-title":"J Clin Ultrasound."},{"issue":"3","key":"4253_CR20","doi-asserted-by":"publisher","first-page":"411","DOI":"10.7863\/ultra.34.3.411","volume":"34","author":"HS Park","year":"2015","unstructured":"Park HS, Kim YJ, Yu MH, et al. Real-time contrast-enhanced sonographically guided biopsy or radiofrequency ablation of focal liver lesions using perflurobutane microbubbles (Sonazoid): value of Kupffer-phase imaging. J Ultrasound Med. 2015 Mar;34(3):411-21.","journal-title":"J Ultrasound Med."},{"issue":"12","key":"4253_CR21","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1016\/j.ultrasmedbio.2015.07.033","volume":"41","author":"T Kondo","year":"2015","unstructured":"Kondo T, Maruyama H, Kiyono S, et al. Intensity-Based Assessment of Microbubble-Enhanced Ultrasonography: Phase-Related Diagnostic Ability for Cellular Differentiation of Hepatocellular Carcinoma. Ultrasound Med Biol. 2015 Dec;41(12):3079-87.","journal-title":"Ultrasound Med Biol."},{"issue":"2","key":"4253_CR22","doi-asserted-by":"publisher","first-page":"W123","DOI":"10.2214\/AJR.10.4242","volume":"196","author":"M Takahashi","year":"2011","unstructured":"Takahashi M, Maruyama H, Ishibashi H, et al. Contrast-enhanced ultrasound with perflubutane microbubble agent: evaluation of differentiation of hepatocellular carcinoma. AJR Am J Roentgenol. 2011 Feb;196(2):W123-31.","journal-title":"AJR Am J Roentgenol."},{"issue":"7","key":"4253_CR23","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/liv.13043","volume":"36","author":"K Sugimoto","year":"2016","unstructured":"Sugimoto K, Shiraishi J, Tanaka H, et al. Computer-aided diagnosis for estimating the malignancy grade of hepatocellular carcinoma using contrast-enhanced ultrasound: an ROC observer study. Liver Int. 2016 Jul;36(7):1026-32.","journal-title":"Liver Int."},{"issue":"3","key":"4253_CR24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.ultrasmedbio.2011.12.006","volume":"38","author":"H Maruyama","year":"2012","unstructured":"Maruyama H, Takahashi M, Sekimoto T, Kamesaki H, Shimada T, Kanai F, Yokosuka O. Heterogeneity of microbubble accumulation: a novel approach to discriminate between well-differentiated hepatocellular carcinomas and regenerative nodules. Ultrasound Med Biol. 2012 Mar;38(3):383-8.","journal-title":"Ultrasound Med Biol."},{"issue":"6","key":"4253_CR25","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.ultrasmedbio.2013.12.019","volume":"40","author":"K Sugimoto","year":"2014","unstructured":"Sugimoto K, Moriyasu F, Saito K, Yoshiara H, Imai Y. Kupffer-phase findings of hepatic hemangiomas in contrast-enhanced ultrasound with sonazoid. Ultrasound Med Biol. 2014 Jun;40(6):1089-95.","journal-title":"Ultrasound Med Biol."},{"issue":"6","key":"4253_CR26","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1002\/jum.14490","volume":"37","author":"J Lee","year":"2018","unstructured":"Lee J, Jeong WK, Lim HK, Kim AY. Focal Nodular Hyperplasia of the Liver: Contrast-Enhanced Ultrasonographic Features With Sonazoid. J Ultrasound Med. 2018 Jun;37(6):1473-1480.\u00a0","journal-title":"J Ultrasound Med."},{"issue":"Suppl 1","key":"4253_CR27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000315232","volume":"78","author":"M Kudo","year":"2010","unstructured":"Kudo M, Hatanaka K, Inoue T, Maekawa K. Depiction of portal supply in early hepatocellular carcinoma and dysplastic nodule: value of pure arterial ultrasound imaging in hepatocellular carcinoma. Oncology. 2010 Jul;78 Suppl 1:60-7.","journal-title":"Oncology."},{"issue":"1","key":"4253_CR28","first-page":"11","volume":"34","author":"M Claudon","year":"2013","unstructured":"Claudon M, Dietrich CF, Choi BI, et al. Guidelines and good clinical practice recommendations for contrast-enhanced ultrasound (CEUS) in the liver--update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med. 2013 Feb;34(1):11-29.","journal-title":"FLAUS and ICUS. Ultraschall Med."},{"issue":"3","key":"4253_CR29","doi-asserted-by":"publisher","first-page":"423","DOI":"10.7863\/ultra.34.3.423","volume":"34","author":"K Suzuki","year":"2015","unstructured":"Suzuki K, Okuda Y, Ota M, et al. Diagnosis of hepatocellular carcinoma nodules in patients with chronic liver disease using contrast-enhanced sonography: usefulness of the combination of arterial- and Kupffer-phase enhancement patterns. J Ultrasound Med. 2015 Mar;34(3):423-33.","journal-title":"J Ultrasound Med."},{"issue":"3","key":"4253_CR30","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1148\/radiol.2017170365","volume":"286","author":"CN Ta","year":"2018","unstructured":"Ta CN, Kono Y, Eghtedari M, et al. Focal Liver Lesions: Computer-aided Diagnosis by Using Contrast-enhanced US Cine Recordings. Radiology. 2018 Mar;286(3):1062-1071.","journal-title":"Radiology."}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-024-04253-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-024-04253-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-024-04253-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T03:45:59Z","timestamp":1726112759000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-024-04253-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["4253"],"URL":"https:\/\/doi.org\/10.1007\/s00261-024-04253-4","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]},"assertion":[{"value":"4 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors disclosed no relevant relationships.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}