{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:41:28Z","timestamp":1777732888895,"version":"3.51.4"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pancreas is a centrally located extraperitoneal organ within the anterior pararenal space. It is extensively connected to the extraperitoneal spaces by location and a network of mesenteries and ligaments. This provides interconnected avenues for vessels, lymphatics, and nerves to course through\u2014as well as avenues for the spread of disease. The head of the pancreas results from the fusion of its ventral analog (anterior head) with its dorsal analog (posterior head). This differentiation provides two distinct pathways of spread of disease from the head of the pancreas. This communication will discuss the embryology, anatomy, and pathways of disease spread from the anterior and posterior pancreatic head. While any disease process can use these pathways, proven cases of adenocarcinoma of the pancreas are used for illustrations.<\/jats:p>","DOI":"10.1007\/s00261-024-04438-x","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T06:02:16Z","timestamp":1718949736000},"page":"416-422","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A head with two tales: demystifying early spread of disease from the pancreatic head"],"prefix":"10.1007","volume":"50","author":[{"given":"Swetha","family":"Aribindi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Oliphant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-0854","authenticated-orcid":false,"given":"Janardhana","family":"Ponnatapura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"4438_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-5939-3","volume-title":"Dynamic radiology of the abdomen: normal and pathologic anatomy","author":"MA Meyers","year":"2011","unstructured":"Meyers, M.A, Charnsangavej, C., & Oliphant, M. (2011) Dynamic radiology of the abdomen: normal and pathologic anatomy, 6th ed. Springer Science & Business Media.","edition":"6"},{"issue":"4","key":"4438_CR2","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/ca.22461","volume":"28","author":"A Cesmebasi","year":"2015","unstructured":"Cesmebasi A, Malefant J, Patel SD, Du Plessis M, Renna S, Tubbs RS, Loukas M. The surgical anatomy of the lymphatic system of the pancreas. Clin Anat. 2015 May;28(4):527-37. doi: https:\/\/doi.org\/10.1002\/ca.22461. Epub 2014 Sep 15. PMID: 25220721.","journal-title":"Clin Anat."},{"key":"4438_CR3","unstructured":"Pandol SJ. The Exocrine Pancreas. San Rafael (CA): Morgan & Claypool Life Sciences; 2010. Pancreatic Embryology and Development. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK54135\/"},{"issue":"5","key":"4438_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/ags3.12459.PMID:34585047;PMCID:PMC8452481","volume":"5","author":"T Wakiya","year":"2021","unstructured":"Wakiya T, Ishido K, Yoshizawa T, Kanda T, Hakamada K. Roles of the nervous system in pancreatic cancer. Ann Gastroenterol Surg. 2021 Mar 29;5(5):623-633. doi: https:\/\/doi.org\/10.1002\/ags3.12459. PMID: 34585047; PMCID: PMC8452481.","journal-title":"Ann Gastroenterol Surg."},{"issue":"5","key":"4438_CR5","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/ca.23470","volume":"33","author":"K Ren","year":"2020","unstructured":"Ren, K., Yi, S. Q., Dai, Y., Kurosawa, K., Miwa, Y., & Sato, I. (2020). Clinical anatomy of the anterior and posterior hepatic plexuses, including relations with the pancreatic plexus: a cadaver study. Clinical Anatomy, 33(5), 630-636.","journal-title":"Clinical Anatomy"},{"key":"4438_CR6","doi-asserted-by":"crossref","unstructured":"Yi, Shuang-Qin*; Miwa, Koichi\u2020; Ohta, Tetsuo\u2020; Kayahara, Masato\u2020; Kitagawa, Hirohisa\u2020; Tanaka, Ai*; Shimokawa, Takashi*; Akita, Keiichi\u2021; Tanaka, Shigenori*. Innervation of the Pancreas from the Perspective of Perineural Invasion of Pancreatic Cancer. Pancreas 27(3):p 225\u2013229, October 2003.","DOI":"10.1097\/00006676-200310000-00005"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-024-04438-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-024-04438-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-024-04438-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:02:40Z","timestamp":1736388160000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-024-04438-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["4438"],"URL":"https:\/\/doi.org\/10.1007\/s00261-024-04438-x","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]},"assertion":[{"value":"28 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}