{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:29:10Z","timestamp":1754144950558,"version":"3.41.2"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK132346"],"award-info":[{"award-number":["R01DK132346"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>T1-weighted signal intensity ratios (SIR) comparing pancreas to spleen (SIRps) or muscle (SIRpm) can semiquantitatively assess T1 signal change associated with pancreatitis. However, there is no standardized methodology for generating these ratios. We set out to determine the impact of MRI sequence as well as region of interest (ROI) location, shape, and size on T1 SIR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Retrospective analysis of T1-weighted MR images from 118 patients acquired 2018\u20132023. A single observer placed ovoid ROIs in the pancreas body\/tail and head\/uncinate, spleen, and left erector spinae muscle and large irregular ROIs in the pancreas tail and spleen. ROIs were placed on images from two sequences: 3D radial 2 point mDIXON RF spoiled gradient recalled echo sequence (radial) and breath-hold 3D 2-point mDIXON RF spoiled gradient echo (BH). T1 SIR were calculated from mean signal intensity, and agreement was calculated with intraclass correlations coefficients (ICC) and Bland\u2013Altman difference analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>118 participants, 57 (48%) female, with\u00a0mean age 13.7\u2009\u00b1\u20095.6\u00a0years (48%) were included. Agreement was good for SIRps based on irregular versus round ROIs (radial: ICC\u2009=\u20090.90; BH: ICC\u2009=\u20090.91). Agreement was moderate for SIR based on sampling the pancreas body\/tail versus head\/uncinate (ICC\u2009=\u20090.67\u20130.76) and poor to moderate based on reference organ (muscle vs. spleen) (ICC\u2009=\u20090.41\u20130.61). Between sequences, agreement was moderate (ICC\u2009=\u20090.55\u20130.72, mean difference 0.04\u20130.09).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The size and shape of the ROI used to sample the pancreas does not meaningfully change T1 SIR but the location sampled, the reference organ used, and the MRI sequence used meaningfully change T1 SIR, potentially impacting disease diagnosis and staging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00261-024-04774-y","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T22:30:09Z","timestamp":1737930609000},"page":"3722-3733","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T1 signal intensity ratio variability based on sampling strategies in the pancreas of children and young adults"],"prefix":"10.1007","volume":"50","author":[{"given":"Arjun K.","family":"Mathur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Dillman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maisam","family":"Abu-El-Haija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean A.","family":"Tkach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Trout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"7","key":"4774_CR1","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1053\/j.gastro.2018.12.043","volume":"156","author":"A Uc","year":"2019","unstructured":"Uc A, Husain SZ (2019) Pancreatitis in Children. 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J Pediatr Gastroenterol Nutr 55 (3):261-265. https:\/\/doi.org\/10.1097\/MPG.0b013e31824f1516","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"4774_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2214\/AJR.21.27234","volume":"219","author":"Trout AT, Abu-El-Haija M, Anupindi SA, Marine MB, Murati M, Phelps AS, Rees MA, Squires JH, Ellery KM, Gariepy CE, Maqbool A, McFerron BA, Perito ER, Schwarzenberg SJ, Zhang B, Andersen DK, Lowe ME, Uc A, Consortium for the Study of Chronic Pancreatitis D, Pancreatic C","year":"2022","unstructured":"Trout AT, Abu-El-Haija M, Anupindi SA, Marine MB, Murati M, Phelps AS, Rees MA, Squires JH, Ellery KM, Gariepy CE, Maqbool A, McFerron BA, Perito ER, Schwarzenberg SJ, Zhang B, Andersen DK, Lowe ME, Uc A, Consortium for the Study of Chronic Pancreatitis D, Pancreatic C (2022) Interobserver Agreement for CT and MRI Findings of Chronic Pancreatitis in Children: A Multicenter Ancillary Study Under the INSPPIRE Consortium. 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Abdom Radiol (NY). https:\/\/doi.org\/10.1007\/s00261-024-04609-w","journal-title":"Abdom Radiol (NY)"},{"issue":"1","key":"4774_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1148\/radiol.2018181353","volume":"290","author":"Tirkes T, Shah ZK, Takahashi N, Grajo JR, Chang ST, Venkatesh SK, Conwell DL, Fogel EL, Park W, Topazian M, Yadav D, Dasyam AK, Consortium for the Study of Chronic Pancreatitis D, Pancreatic C","year":"2019","unstructured":"Tirkes T, Shah ZK, Takahashi N, Grajo JR, Chang ST, Venkatesh SK, Conwell DL, Fogel EL, Park W, Topazian M, Yadav D, Dasyam AK, Consortium for the Study of Chronic Pancreatitis D, Pancreatic C (2019) Reporting Standards for Chronic Pancreatitis by Using CT, MRI, and MR Cholangiopancreatography: The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. 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