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Despite its short length, the descending part (D2 segment) holds clinical significance due to its anatomical proximity to structures such as the gallbladder, right kidney, colon, and pancreas. This anatomical localization and contiguity give rise to various pathologies, including congenital, inflammatory, infectious, neoplastic, vascular, and traumatic conditions. Cross-sectional imaging modalities play a pivotal role in evaluating pathologies of the second (D2) segment of the duodenum. This article aims to provide a comprehensive overview of these pathologies and delineate their imaging characteristics.<\/jats:p>","DOI":"10.1007\/s00261-025-04846-7","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T14:40:56Z","timestamp":1740321656000},"page":"3970-3983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A pictorial essay on cross-sectional imaging findings of pathologies in the second (D2) segment of the duodenum in adults"],"prefix":"10.1007","volume":"50","author":[{"given":"Isil","family":"Basara Akin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Enes","family":"Oguzturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengisu","family":"Kandemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal Deniz","family":"Mentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"4846_CR1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.5114\/pjr.2020.95477","volume":"85","author":"A Reghunath","year":"2020","unstructured":"Reghunath A, Kabilan K, Mittal MK (2020) Exploring the neglected segment of the intestine: the duodenum and its pathologies.\u00a0Pol J Radiol 85:230-244. https:\/\/doi.org\/10.5114\/pjr.2020.95477","journal-title":"Pol J Radiol"},{"key":"4846_CR2","volume-title":"Anatomy for Diagnostic Imaging","author":"S Ryan","year":"2024","unstructured":"Ryan S, McNicholas M, Eustace SJ (2024) Anatomy for Diagnostic Imaging. 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