{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:34:15Z","timestamp":1761849255708,"version":"build-2065373602"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Postgraduate Research & Practice lnnovation Program of jiangsu Province","award":["SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633"],"award-info":[{"award-number":["SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633","SJCX22-1633"]}]},{"name":"Translational Medicine Foundation from Jiangsu Society of Research Hospital","award":["GY202203","GY202203","GY202203","GY202203","GY202203","GY202203","GY202203","GY202203"],"award-info":[{"award-number":["GY202203","GY202203","GY202203","GY202203","GY202203","GY202203","GY202203","GY202203"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"DOI":"10.1007\/s00261-025-04985-x","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T05:14:20Z","timestamp":1747113260000},"page":"5253-5262","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intrahepatic diffuse periportal hyperintensity patterns on hepatobiliary phase of gadoxetate-enhanced MRI: a non-invasive imaging biomarker for clinical stratification of liver injury"],"prefix":"10.1007","volume":"50","author":[{"given":"Feifei","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jifeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinrong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"issue":"1","key":"4985_CR1","doi-asserted-by":"publisher","first-page":"e233114","DOI":"10.1148\/radiol.233114","volume":"311","author":"JH Yoon","year":"2024","unstructured":"Yoon JH, Kim YK, Kim JW, et al (2024) Comparison of Four Diagnostic Guidelines for Hepatocellular Carcinoma Using Gadoxetic Acid-enhanced Liver MRI. Radiology 311(1):e233114. https:\/\/doi.org\/10.1148\/radiol.233114.","journal-title":"Radiology"},{"issue":"1","key":"4985_CR2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/RLI.0000000000000990","volume":"59","author":"S Ichikawa","year":"2024","unstructured":"Ichikawa S, Goshima S (2024) Gadoxetic Acid-Enhanced Liver MRI: Everything You Need to Know. Invest Radiol 59(1):53-68. https:\/\/doi.org\/10.1097\/RLI.0000000000000990.","journal-title":"Invest Radiol"},{"issue":"1","key":"4985_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12880-023-01028-z","volume":"23","author":"B Ma","year":"2023","unstructured":"Ma B, Xu H, Wu X, et al (2023) Evaluation of liver function using Gd-EOB-DTPA-enhanced MRI with T1 mapping. BMC Med Imaging 23(1):73. https:\/\/doi.org\/10.1186\/s12880-023-01028-z.","journal-title":"BMC Med Imaging"},{"key":"4985_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2024.111288","volume":"171","author":"DN Rybczynska","year":"2024","unstructured":"Rybczynska DN, Markiet KE, Pienkowska JM, et al (2024) To assess the quantitative features of focal liver lesions in gadoxetic acid enhanced MRI and to determine whether these features can accurately differentiate benign form malignant lesions. Eur J Radiol 171:111288. https:\/\/doi.org\/10.1016\/j.ejrad.2024.111288.","journal-title":"Eur J Radiol"},{"issue":"5","key":"4985_CR5","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1007\/s00330-023-09489-0","volume":"33","author":"S Cai","year":"2023","unstructured":"Cai S, Lin N, Yang Y, et al (2023) The value of contrast-enhanced portal vein imaging at the hepatobiliary phase obtained with gadobenate dimeglumine for predicting decompensation and transplant-free survival in chronic liver disease. Eur Radiol 33(5):3425-3434. https:\/\/doi.org\/10.1007\/s00330-023-09489-0.","journal-title":"Eur Radiol"},{"issue":"1","key":"4985_CR6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13244-024-01629-4","volume":"15","author":"L Cong","year":"2024","unstructured":"Cong L, Deng Y, Cai S, et al (2024) The value of periportal hyperintensity sign from gadobenate dimeglumine-enhanced hepatobiliary phase MRI for predicting clinical outcomes in patients with decompensated cirrhosis. Insights into imaging 15(1):117. https:\/\/doi.org\/10.1186\/s13244-024-01629-4.","journal-title":"Insights Imaging"},{"issue":"1","key":"4985_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13244-020-00928-w","volume":"12","author":"F Vernuccio","year":"2021","unstructured":"Vernuccio F, Gagliano DS, Cannella R, et al (2021) Spectrum of liver lesions hyperintense on hepatobiliary phase: an approach by clinical setting. Insights Imaging 12(1):8. https:\/\/doi.org\/10.1186\/s13244-020-00928-w.","journal-title":"Insights Imaging"},{"issue":"1112","key":"4985_CR8","doi-asserted-by":"publisher","first-page":"20190989","DOI":"10.1259\/bjr.20190989","volume":"93","author":"CL Hui","year":"2020","unstructured":"Hui CL, Mautone M (2020) Patterns of enhancement in the hepatobiliary phase of gadoxetic acid-enhanced MRI. Br J Radiol 93(1112):20190989. https:\/\/doi.org\/10.1259\/bjr.20190989.","journal-title":"Br J Radiol"},{"issue":"11","key":"4985_CR9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014784","volume":"98","author":"H Onishi","year":"2019","unstructured":"Onishi H, Theisen D, Zachoval R, et al (2019) Intrahepatic diffuse periportal enhancement patterns on hepatobiliary phase gadoxetate disodium-enhanced liver MR images: Do they correspond to periportal hyperintense patterns on T2-weighted images?. Medicine (Baltimore) 98(11):e14784. https:\/\/doi.org\/10.1097\/MD.0000000000014784.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"4985_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11604-012-0136-x","volume":"31","author":"S Kobayashi","year":"2013","unstructured":"Kobayashi S, Matsui O, Gabata T, et al (2013) Intrahepatic periportal high intensity on hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI: imaging findings and prevalence in various hepatobiliary diseases. Jpn J Radiol 31(1):9-15. https:\/\/doi.org\/10.1007\/s11604-012-0136-x.","journal-title":"Jpn J Radiol"},{"issue":"4","key":"4985_CR11","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1097\/00004728-199207000-00012","volume":"16","author":"H Itoh","year":"1992","unstructured":"Itoh H, Sakai T, Takahashi N, et al (1992) Periportal high intensity on T2-weighted MR images in acute viral hepatitis. J Comput Assist Tomogr 16(4):564-567. https:\/\/doi.org\/10.1097\/00004728-199207000-00012.","journal-title":"J Comput Assist Tomogr"},{"issue":"3","key":"4985_CR12","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/jmri.23700","volume":"36","author":"NK Lee","year":"2012","unstructured":"Lee NK, Kim S, Kim GH, et al (2012) Significance of the \"delayed hyperintense portal vein sign\" in the hepatobiliary phase MRI obtained with Gd-EOB-DTPA. J Magn Reson Imaging 36(3):678-685. https:\/\/doi.org\/10.1002\/jmri.23700.","journal-title":"J Magn Reson Imaging"},{"issue":"12","key":"4985_CR13","doi-asserted-by":"publisher","first-page":"6489","DOI":"10.1007\/s00330-019-06329-y","volume":"29","author":"K Kozaka","year":"2019","unstructured":"Kozaka K, Kobayashi S, Yoneda N, et al (2019) Doughnut-like hyperintense nodules on hepatobiliary phase without arterial-phase hyperenhancement in cirrhotic liver: imaging and clinicopathological features. Eur Radiol 29(12):6489-6498. https:\/\/doi.org\/10.1007\/s00330-019-06329-y.","journal-title":"Eur Radiol"},{"issue":"4","key":"4985_CR14","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10396-023-01353-4","volume":"50","author":"R Kubota","year":"2001","unstructured":"Kubota R, Toshikuni N, Tsutsumi M, et al (2023) Sonazoid-enhanced ultrasound images of multiacinar cirrhotic nodules showing a \"donut-like\" hyperintense appearance on Gd-EOB-MRI: a case report. J Med Ultrason (2001) 50(4):573-574. https:\/\/doi.org\/10.1007\/s10396-023-01353-4.","journal-title":"J Med Ultrason"},{"issue":"10","key":"4985_CR15","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1007\/s00125-020-05209-1","volume":"63","author":"S Wang","year":"2020","unstructured":"Wang S, Ma P, Zhang S, et al (2020) Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study. Diabetologia 63(10):2102-2111. https:\/\/doi.org\/10.1007\/s00125-020-05209-1.","journal-title":"Diabetologia"},{"issue":"7","key":"4985_CR16","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.cgh.2014.11.036","volume":"13","author":"SA Alqahtani","year":"2015","unstructured":"Alqahtani SA, Kleiner DE, Ghabril M, et al (2015) Identification and Characterization of Cefazolin-Induced Liver Injury. Clin Gastroenterol Hepatol 13(7):1328-1336.e2. https:\/\/doi.org\/10.1016\/j.cgh.2014.11.036.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"4985_CR17","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1007\/s00261-023-03859-4","volume":"48","author":"JD Kova\u010d","year":"2024","unstructured":"Kova\u010d JD, Milovanovi\u0107 T (2024) \"MRI periportal halo sign\" in primary biliary cirrhosis. Abdom Radiol (NY) 48(4):1556-1557. https:\/\/doi.org\/10.1007\/s00261-023-03859-4.","journal-title":"Abdom Radiol (NY)"},{"issue":"1","key":"4985_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260436","volume":"17","author":"S Dressel-B\u00f6hm","year":"2022","unstructured":"Dressel-B\u00f6hm S, Richter H, Kircher PR, et al (2022) Hypoattenuating periportal halo on CT in a patient population can occur in presence of a variety of diseases. PLoS One 17(1):e0260436. https:\/\/doi.org\/10.1371\/journal.pone.0260436.","journal-title":"PLoS One"},{"issue":"11","key":"4985_CR19","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s11547-017-0789-8","volume":"122","author":"J Shu","year":"2017","unstructured":"Shu J, Zhao JN, Han FG, et al (2017) Chronic hepatitis B: correlation of abnormal features on T2-weighted imaging and dynamic contrast-enhanced imaging with hepatic histopathology. Radiol Med 122(11):807-813. https:\/\/doi.org\/10.1007\/s11547-017-0789-8.","journal-title":"Radiol Med"},{"issue":"10","key":"4985_CR20","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1007\/s00261-017-1155-y","volume":"42","author":"Y Yamada","year":"2017","unstructured":"Yamada Y, Matsumoto S, Mori H, et al (2017) Periportal lymphatic system on post-hepatobiliary phase Gd-EOB-DTPA-enhanced MR imaging in normal subjects and patients with chronic hepatitis C. Abdom Radiol (NY) 42(10):2410-2419. https:\/\/doi.org\/10.1007\/s00261-017-1155-y.","journal-title":"Abdom Radiol (NY)"},{"key":"4985_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00261-017-1155-y","volume":"15","author":"ST Feng","year":"2015","unstructured":"Feng ST, Wu L, Cai H, et al (2015) Cholangiocarcinoma: spectrum of appearances on Gd-EOB-DTPA-enhanced MR imaging and the effect of biliary function on signal intensity. BMC Cancer 15:38. https:\/\/doi.org\/10.1007\/s00261-017-1155-y.","journal-title":"BMC Cancer"},{"issue":"11","key":"4985_CR22","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.ejrad.2016.09.003","volume":"85","author":"Y Noda","year":"2016","unstructured":"Noda Y, Goshima S, Kajita K, et al (2016) Biliary tract enhancement in gadoxetic acid-enhanced MRI correlates with liver function biomarkers. Eur J Radiol 85(11):2001-2007. https:\/\/doi.org\/10.1016\/j.ejrad.2016.09.003.","journal-title":"Eur J Radiol"},{"issue":"2","key":"4985_CR23","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1053\/j.gastro.2009.05.038","volume":"137","author":"M Colletti","year":"2009","unstructured":"Colletti M, Cicchini C, Conigliaro A, et al (2009) Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation. Gastroenterology 137(2):660\u2013672. https:\/\/doi.org\/10.1053\/j.gastro.2009.05.038.","journal-title":"Gastroenterology"},{"issue":"1","key":"4985_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1148\/rg.2020190037","volume":"40","author":"N Fujita","year":"2020","unstructured":"Fujita N, Nishie A, Asayama Y, et al (2020) Hyperintense Liver Masses at Hepatobiliary Phase Gadoxetic Acid-enhanced MRI: Imaging Appearances and Clinical Importance. Radiographics 40(1):72-94. https:\/\/doi.org\/10.1148\/rg.2020190037.","journal-title":"Radiographics"},{"issue":"9","key":"4985_CR25","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1007\/s00261-018-1482-7","volume":"43","author":"E \u00dcnal","year":"2018","unstructured":"\u00dcnal E, Karaosmano\u011flu AD, Ozmen MN, et al (2018) Hepatobiliary phase liver MR imaging findings after Oxaliplatin-based chemotherapy in cancer patients. Abdom Radiol (NY) 43(9):2321-2328. https:\/\/doi.org\/10.1007\/s00261-018-1482-7.","journal-title":"Abdom Radiol (NY)"},{"issue":"2","key":"4985_CR26","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1007\/s00330-023-10080-w","volume":"34","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Fan X, Song B, et al (2024) Noninvasive prediction of insufficient biochemical response after ursodeoxycholic acid treatment in patients with primary biliary cholangitis based on pretreatment nonenhanced MRI. Eur Radiol 34(2):1268-1279. https:\/\/doi.org\/10.1007\/s00330-023-10080-w.","journal-title":"Eur Radiol"},{"issue":"2","key":"4985_CR27","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/cns.13759","volume":"28","author":"Q Peng","year":"2022","unstructured":"Peng Q, Bi R, Chen S, et al (2022) Predictive value of different bilirubin subtypes for clinical outcomes in patients with acute ischemic stroke receiving thrombolysis therapy. CNS Neurosci Ther 28(2):226-236. https:\/\/doi.org\/10.1111\/cns.13759.","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"4985_CR28","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1002\/hep.32289","volume":"75","author":"J Remetic","year":"2022","unstructured":"Remetic J, Ghallab A, Hobloss Z, et al (2022) Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology 75(5):1095-1109. https:\/\/doi.org\/10.1002\/hep.32289.","journal-title":"Hepatology"},{"key":"4985_CR29","doi-asserted-by":"publisher","first-page":"5653700","DOI":"10.1155\/2021\/5653700","volume":"2021","author":"Q Cheng","year":"2021","unstructured":"Cheng Q, Ding H, Fang J, et al. Aquaporin 9 Represents a Novel Target of Chronic Liver Injury That May Antagonize Its Progression by Reducing Lipotoxicity. Oxid Med Cell Longev. 2021;2021:5653700. https:\/\/doi.org\/10.1155\/2021\/5653700.","journal-title":"Oxid Med Cell Longev"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-04985-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-025-04985-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-04985-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:13:09Z","timestamp":1761847989000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-025-04985-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["4985"],"URL":"https:\/\/doi.org\/10.1007\/s00261-025-04985-x","relation":{},"ISSN":["2366-0058"],"issn-type":[{"type":"electronic","value":"2366-0058"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"5 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was complied with the principles of the Declaration of Helsinki and was approved by the institutional review board of Nantong Third People's Hospital, Nantong University (No. EK2021017).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}