{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:29:12Z","timestamp":1789410552208,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the diagnostic performance of tumor capsule contact length (TCCL) and to determine its optimal cut-off on prostate MRI to predict extra-capsular extension (ECE) at histopathology of radical prostatectomy specimen in patients with prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>An electronic search of the PUBMED and EMBASE databases was performed until December 31, 2024 to identify studies analyzing TCCL as a predictor of ECE on prostate MRI. Pooled sensitivity and specificity of all studies were plotted in a hierarchical summary receiver operating characteristic plot and the risk of ECE was evaluated using bivariate random-effects meta-analysis. Meta-regression analysis for various TCCL cut-offs was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-three eligible studies were found. Reported sensitivity (between 47 \u2212\u200994%) and specificity (between 46 \u2212\u200988%) showed significant heterogeneity between studies, without evident threshold effect. Pooled sensitivity and specificity of TCCL for predicting ECE was 76.3% and 68.8% respectively with AUC of 0.787 for the summary ROC curve. Meta-regression analysis showed no significant difference in diagnostic performance according to various TCCL cutoffs, measurement methods, or ISUP grade distribution. Studies with 14\u00a0mm threshold had similar sensitivity (73%), but greater specificity (74% vs. 70%) and diagnostic odds ratio (8.3 vs. 6.5), when compared to 10\u00a0mm threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCCL on MRI has reasonable pooled sensitivity and specificity to predict ECE. While sensitivity remained moderately high for all TCCL thresholds, specificity at 14\u00a0mm (cutoff close to 15\u00a0mm suggested by PI-RADS v1.0) threshold was greater than that at 10\u00a0mm (cutoff suggested by PIRADS v2.1). This cutoff can be helpful in developing objective likelihood scores for ECE prediction on MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00261-025-04998-6","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:37:10Z","timestamp":1749098230000},"page":"6106-6118","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["10\u00a0mm (PI-RADS v2.1) versus 15\u00a0mm (PI-RADS v1.0) tumor capsule contact length in predicting extracapsular extension in prostate cancer: Meta-analysis and systematic review"],"prefix":"10.1007","volume":"50","author":[{"given":"Dheeman","family":"Futela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahima","family":"Bhargava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharath","family":"Rama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sishir","family":"Doddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil H","family":"Ramaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree Harsha","family":"Tirumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"4998_CR1","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1001\/jama.2017.7248","volume":"317","author":"MS Litwin","year":"2017","unstructured":"Litwin MS, Tan HJ. The Diagnosis and Treatment of Prostate Cancer: A Review. JAMA. 2017;317:2532\u20132542.","journal-title":"JAMA"},{"key":"4998_CR2","doi-asserted-by":"publisher","first-page":"620","DOI":"10.6004\/jnccn.2018.0036","volume":"16","author":"PH Carroll","year":"2018","unstructured":"Carroll PH, Mohler JL. NCCN Guidelines Updates: Prostate Cancer and Prostate Cancer Early Detection. J Natl Compr Canc Netw. 2018;16:620\u2013623.","journal-title":"J Natl Compr Canc Netw"},{"key":"4998_CR3","doi-asserted-by":"publisher","first-page":"e0210194","DOI":"10.1371\/journal.pone.0210194","volume":"14","author":"M Kozikowski","year":"2019","unstructured":"Kozikowski M, Malewski W, Michalak W, Dobruch J. Clinical utility of MRI in the decision-making process before radical prostatectomy: Systematic review and meta-analysis. PLoS One. 2019;14:e0210194.","journal-title":"PLoS One"},{"key":"4998_CR4","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1001\/jamaoncol.2017.5667","volume":"4","author":"S Mehralivand","year":"2018","unstructured":"Mehralivand S, Shih JH, S RB. A Magnetic Resonance Imaging-Based Prediction Model for Prostate Biopsy Risk Stratification. JAMA Oncol. 2018;4:678\u2013685.","journal-title":"JAMA Oncol"},{"key":"4998_CR5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.eururo.2018.05.035","volume":"75","author":"AR Padhani","year":"2019","unstructured":"Padhani AR, Weinreb J, Rosenkrantz AB, Villeirs G, Turkbey B, Barentsz J. Prostate Imaging-Reporting and Data System Steering Committee: PI-RADS v2 Status Update and Future Directions. Eur Urol. 2019;75:385\u2013396.","journal-title":"Eur Urol"},{"key":"4998_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41585-019-0212-4","volume":"17","author":"A Stabile","year":"2020","unstructured":"Stabile A, Giganti F, AB R. Multiparametric MRI for prostate cancer diagnosis: current status and future directions. Nat Rev Urol. 2020;17:41\u201361.","journal-title":"Nat Rev Urol"},{"key":"4998_CR7","doi-asserted-by":"publisher","unstructured":"Baumgartner EM, Porter KK, Nix JW, Rais-Bahrami S, Gordetsky JB. Detection of extraprostatic disease and seminal vesicle invasion in patients undergoing magnetic resonance imaging-targeted prostate biopsies. Transl Androl Urol. 2018;7(Suppl 4):S392\u2013S396. https:\/\/doi.org\/10.21037\/tau.2018.03.15.","DOI":"10.21037\/tau.2018.03.15"},{"key":"4998_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.eururo.2015.07.029","volume":"70","author":"MR EH","year":"2016","unstructured":"M R, EH H, JA W, JO B, MM R. Accuracy of Magnetic Resonance Imaging for Local Staging of Prostate Cancer: A Diagnostic Meta-analysis. Eur Urol. 2016;70:233\u2013245.","journal-title":"Eur Urol"},{"key":"4998_CR9","doi-asserted-by":"publisher","first-page":"576","DOI":"10.2214\/AJR.18.20320","volume":"212","author":"Y Freifeld","year":"2019","unstructured":"Freifeld Y, Leon A, Y X. Diagnostic Performance of Prospectively Assigned Likert Scale Scores to Determine Extraprostatic Extension and Seminal Vesicle Invasion With Multiparametric MRI of the Prostate. AJR Am J Roentgenol. 2019;212:576\u2013581.","journal-title":"AJR Am J Roentgenol"},{"key":"4998_CR10","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1007\/s00330-011-2377-y","volume":"22","author":"JO Barentsz","year":"2012","unstructured":"Barentsz JO, Richenberg J, R C. ESUR prostate MR guidelines 2012. Eur Radiol. 2012;22:746\u2013757.","journal-title":"Eur Radiol"},{"key":"4998_CR11","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.juro.2014.08.084","volume":"193","author":"E Baco","year":"2015","unstructured":"Baco E, Rud E, L V. Predictive value of magnetic resonance imaging determined tumor contact length for extracapsular extension of prostate cancer. J Urol. 2015;193:466\u2013472.","journal-title":"J Urol"},{"key":"4998_CR12","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/jmri.25040","volume":"43","author":"AB Rosenkrantz","year":"2016","unstructured":"Rosenkrantz AB, Shanbhogue AK, Wang A, Kong MX, Babb JS, Taneja SS. Length of capsular contact for diagnosing extraprostatic extension on prostate MRI: Assessment at an optimal threshold. J Magn Reson Imaging. 2016;43:990\u2013997.","journal-title":"J Magn Reson Imaging"},{"key":"4998_CR13","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.2214\/AJR.17.18849","volume":"210","author":"DN LJ Costa","year":"2018","unstructured":"Costa DN LJ et al Passoni NM. Diagnostic Utility of a Likert Scale Versus Qualitative Descriptors and Length of Capsular Contact for Determining Extraprostatic Tumor Extension at Multiparametric Prostate MRI. AJR Am J Roentgenol. 2018;210:1066\u20131072.","journal-title":"AJR Am J Roentgenol"},{"key":"4998_CR14","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1590\/s1677-5538.ibju.2016.0485","volume":"44","author":"C Dominguez","year":"2018","unstructured":"Dominguez C, Plata M, JG C. Diagnostic accuracy of multiparametric magnetic resonance imaging in detecting extracapsular extension in intermediate and high - risk prostate cancer. Int Braz J Urol. 2018;44:688\u2013696.","journal-title":"Int Braz J Urol"},{"key":"4998_CR15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.rx.2017.03.003","volume":"59","author":"MF Granja","year":"2017","unstructured":"Granja MF, Pedraza CM, Florez DC, Romero JA, Palau MA, Aguirre DA. Predicting extracapsular involvement in prostate cancer through the tumor contact length and the apparent diffusion coefficient. Radiologia. 2017;59:313\u2013320.","journal-title":"Radiologia"},{"issue":"30","key":"4998_CR16","first-page":"31","volume":"35","author":"M Kongnyuy","year":"2017","unstructured":"Kongnyuy M, Sidana A, AK G. Tumor contact with prostate capsule on magnetic resonance imaging: A potential biomarker for staging and prognosis. Urol Oncol. 2017;35(30):31\u2013\u200930 38.","journal-title":"Urol Oncol"},{"key":"4998_CR17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/jmri.25729","volume":"47","author":"S Krishna","year":"2018","unstructured":"Krishna S, Lim CS, MDF M. Evaluation of MRI for diagnosis of extraprostatic extension in prostate cancer. J Magn Reson Imaging. 2018;47:176\u2013185.","journal-title":"J Magn Reson Imaging"},{"key":"4998_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-019-0136-3","author":"K Matsumoto","year":"2019","unstructured":"Matsumoto K, Akita H, K N. Prediction of extraprostatic extension by MRI tumor contact length: difference between anterior and posterior prostate cancer. Prostate Cancer Prostatic Dis. Published online 2019. doi:https:\/\/doi.org\/10.1038\/s41391-019-0136-3","journal-title":"Prostate Cancer Prostatic Dis. Published online"},{"key":"4998_CR19","doi-asserted-by":"crossref","unstructured":"Matsuoka Y, Ishioka J, H T. Impact of the Prostate Imaging Reporting and Data System. In: Version 2, on MRI Diagnosis for Extracapsular Extension of Prostate Cancer.; 2017.","DOI":"10.2214\/AJR.16.17163"},{"key":"4998_CR20","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1148\/radiol.2018181278","volume":"290","author":"S Mehralivand","year":"2019","unstructured":"Mehralivand S, Shih JH, S H. A Grading System for the Assessment of Risk of Extraprostatic Extension of Prostate Cancer at Multiparametric MRI. Radiology. 2019;290:709\u2013719.","journal-title":"Radiology"},{"key":"4998_CR21","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.clinimag.2018.04.020","volume":"50","author":"G Mendez","year":"2018","unstructured":"Mendez G, Foster BR, X L. Endorectal MR imaging of prostate cancer: Evaluation of tumor capsular contact length as a sign of extracapsular extension. Clin Imaging. 2018;50:280\u2013285.","journal-title":"Clin Imaging"},{"key":"4998_CR22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ejrad.2019.01.020","volume":"112","author":"A Onay","year":"2019","unstructured":"Onay A, Vural M, A A. Evaluation of the most optimal multiparametric magnetic resonance imaging sequence for determining pathological length of capsular contact. Eur J Radiol. 2019;112:192\u2013199.","journal-title":"Eur J Radiol"},{"key":"4998_CR23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00345-018-2171-4","volume":"36","author":"E Rud","year":"2018","unstructured":"Rud E, Diep L, Baco E. A prospective study evaluating indirect MRI-signs for the prediction of extraprostatic disease in patients with prostate cancer: tumor volume, tumor contact length and tumor apparent diffusion coefficient. World J Urol. 2018;36:629\u2013637.","journal-title":"World J Urol"},{"key":"4998_CR24","doi-asserted-by":"publisher","first-page":"W168-175","DOI":"10.2214\/AJR.14.12939","volume":"204","author":"S Woo","year":"2015","unstructured":"Woo S, Cho JY, Kim SY, Kim SH. Extracapsular extension in prostate cancer: added value of diffusion-weighted MRI in patients with equivocal findings on T2-weighted imaging. AJR Am J Roentgenol. 2015;204:W168-175.","journal-title":"AJR Am J Roentgenol"},{"issue":"10","key":"4998_CR25","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1111\/iju.14633","volume":"28","author":"S Miyamoto","year":"2021","unstructured":"Miyamoto S, Goto K, Honda Y, et al. Tumor contact length of prostate cancer determined by a three-dimensional method on multiparametric magnetic resonance imaging predicts extraprostatic extension and biochemical recurrence. Int J Urol Off J Jpn Urol Assoc. 2021;28(10):1012\u20131018. doi:https:\/\/doi.org\/10.1111\/iju.14633","journal-title":"Int J Urol Off J Jpn Urol Assoc"},{"issue":"Suppl 2","key":"4998_CR26","doi-asserted-by":"publisher","first-page":"S639-S644","DOI":"10.4103\/jcrt.jcrt_1253_22","volume":"19","author":"M Ayaz","year":"2023","unstructured":"Ayaz M, G\u00fclseren Y, \u0130nan \u0130, Ok F, Kabaalio\u011flu A, Y\u0131ld\u0131r\u0131m A. Extraprostatic extension in multiparametric MRI; Is presurgical detection possible? J Cancer Res Ther. 2023;19(Suppl 2):S639-S644. doi:https:\/\/doi.org\/10.4103\/jcrt.jcrt_1253_22","journal-title":"J Cancer Res Ther"},{"issue":"8","key":"4998_CR27","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1007\/s00261-021-03063-2","volume":"46","author":"K Eurboonyanun","year":"2021","unstructured":"Eurboonyanun K, Pisuchpen N, O\u2019Shea A, Lahoud RM, Atre ID, Harisinghani M. The absolute tumor-capsule contact length in the diagnosis of extraprostatic extension of prostate cancer. Abdom Radiol. 2021;46(8):4014\u20134024. doi:https:\/\/doi.org\/10.1007\/s00261-021-03063-2","journal-title":"Abdom Radiol"},{"issue":"6","key":"4998_CR28","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1007\/s00261-020-02913-9","volume":"46","author":"B Valentin","year":"2021","unstructured":"Valentin B, Schimm\u00f6ller L, Ullrich T, et al. Magnetic resonance imaging improves the prediction of tumor staging in localized prostate cancer. Abdom Radiol. 2021;46(6):2751\u20132759. doi:https:\/\/doi.org\/10.1007\/s00261-020-02913-9","journal-title":"Abdom Radiol"},{"key":"4998_CR29","doi-asserted-by":"publisher","first-page":"111753","DOI":"10.1016\/j.ejrad.2024.111753","volume":"181","author":"U Asfuro\u011flu","year":"2024","unstructured":"Asfuro\u011flu U, Asfuro\u011flu BB, \u00d6zer H, \u0130nan MA, U\u00e7ar M. A comparative analysis of techniques for measuring tumor contact length in predicting extraprostatic extension. Eur J Radiol. 2024;181:111753. doi:https:\/\/doi.org\/10.1016\/j.ejrad.2024.111753","journal-title":"Eur J Radiol"},{"issue":"10","key":"4998_CR30","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1007\/s00330-019-06070-6","volume":"29","author":"I Caglic","year":"2019","unstructured":"Caglic I, Povalej Brzan P, Warren AY, Bratt O, Shah N, Barrett T. Defining the incremental value of 3D T2-weighted imaging in the assessment of prostate cancer extracapsular extension. Eur Radiol. 2019;29(10):5488\u20135497. doi:https:\/\/doi.org\/10.1007\/s00330-019-06070-6","journal-title":"Eur Radiol"},{"key":"4998_CR31","doi-asserted-by":"publisher","first-page":"588","DOI":"10.2214\/AJR.19.21828","volume":"214","author":"B Bakir","year":"2020","unstructured":"Bakir B, Onay A, Vural M, Armutlu A, Yildiz SO, Esen T. Can Extraprostatic Extension Be Predicted by Tumor-Capsule Contact Length in Prostate Cancer? Relationship With International Society of Urological Pathology Grade Groups. AJR Am J Roentgenol. 2020;214:588\u2013596.","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"4998_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1148\/radiol.2020192133","volume":"296","author":"KJ Park","year":"2020","unstructured":"Park KJ, Kim M hyun, Kim JK. Extraprostatic Tumor Extension: Comparison of Preoperative Multiparametric MRI Criteria and Histopathologic Correlation after Radical Prostatectomy. Radiology. 2020;296(1):87\u201395. doi:https:\/\/doi.org\/10.1148\/radiol.2020192133","journal-title":"Radiology"},{"issue":"7","key":"4998_CR33","doi-asserted-by":"publisher","first-page":"4942","DOI":"10.1007\/s00330-022-08595-9","volume":"32","author":"M Gatti","year":"2022","unstructured":"Gatti M, Faletti R, Gentile F, et al. mEPE-score: a comprehensive grading system for predicting pathologic extraprostatic extension of prostate cancer at multiparametric magnetic resonance imaging. Eur Radiol. 2022;32(7):4942\u20134953. doi:https:\/\/doi.org\/10.1007\/s00330-022-08595-9","journal-title":"Eur Radiol"},{"issue":"3","key":"4998_CR34","doi-asserted-by":"publisher","first-page":"477","DOI":"10.2463\/mrms.mp.2020-0182","volume":"21","author":"K Ito","year":"2022","unstructured":"Ito K, Chiba E, Oyama-Manabe N, et al. Combining the Tumor Contact Length and Apparent Diffusion Coefficient Better Predicts Extraprostatic Extension of Prostate Cancer with Capsular Abutment: A 3 Tesla MR Imaging Study. Magn Reson Med Sci MRMS Off J Jpn Soc Magn Reson Med. 2022;21(3):477\u2013484. doi:https:\/\/doi.org\/10.2463\/mrms.mp.2020-0182","journal-title":"Magn Reson Med Sci MRMS Off J Jpn Soc Magn Reson Med"},{"issue":"1","key":"4998_CR35","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s13244-023-01516-4","volume":"14","author":"L Xu","year":"2023","unstructured":"Xu L, Zhang G, Zhang D, et al. An MRI-based grading system for preoperative risk estimation of positive surgical margin after radical prostatectomy. Insights Imaging. 2023;14(1):178. doi:https:\/\/doi.org\/10.1186\/s13244-023-01516-4","journal-title":"Insights Imaging"},{"issue":"6","key":"4998_CR36","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3348\/kjr.2019.0842","volume":"21","author":"TH Kim","year":"2020","unstructured":"Kim TH, Woo S, Han S, et al. The Diagnostic Performance of the Length of Tumor Capsular Contact on MRI for Detecting Prostate Cancer Extraprostatic Extension: A Systematic Review and Meta-Analysis. Korean J Radiol. 2020;21(6):684\u2013694. doi:https:\/\/doi.org\/10.3348\/kjr.2019.0842","journal-title":"Korean J Radiol"},{"key":"4998_CR37","doi-asserted-by":"crossref","unstructured":"Liberati A, Altman DG, J T. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. BMJ 2009;339:b2700.","DOI":"10.1136\/bmj.b2700"},{"key":"4998_CR38","doi-asserted-by":"crossref","unstructured":"Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003;3:25.","DOI":"10.1186\/1471-2288-3-25"},{"key":"4998_CR39","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","volume":"58","author":"JB Reitsma","year":"2005","unstructured":"Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol. 2005;58:982\u2013990.","journal-title":"J Clin Epidemiol"},{"key":"4998_CR40","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","volume":"58","author":"JJ Deeks","year":"2005","unstructured":"Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol. 2005;58:882\u2013893.","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"4998_CR41","first-page":"28","volume":"42","author":"DM Dahl","year":"2024","unstructured":"Dahl DM, Wu S, Lin SX, et al. Clinical significance of prostate cancer identified by transperineal standard template biopsy in men with nonsuspicious multiparametric magnetic resonance imaging. Urol Oncol Semin Orig Investig. 2024;42(2):28.e21-28.e28 doi:10.1016\/j.urolonc.2023.11.004","journal-title":"Urol Oncol Semin Orig Investig"},{"issue":"8","key":"4998_CR42","first-page":"355.e","volume":"41","author":"T Chandrasekar","year":"2023","unstructured":"Chandrasekar T, Denisenko A, Mico V, et al. Multiparametric MRI is not sufficient for prostate cancer staging: A single institutional experience validated by a multi-institutional regional collaborative. Urol Oncol Semin Orig Investig. 2023;41(8):355.e1-355.e8. doi:10.1016\/j.urolonc.2023.05.004","journal-title":"Urol Oncol Semin Orig Investig"},{"key":"4998_CR43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s00330-019-06340-3","volume":"30","author":"H Ahn","year":"2020","unstructured":"Ahn H, Hwang SI, HJ L. Prediction of extraprostatic extension on multi-parametric magnetic resonance imaging in patients with anterior prostate cancer. Eur Radiol. 2020;30:26\u201337.","journal-title":"Eur Radiol"},{"issue":"6","key":"4998_CR44","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.urology.2008.05.045","volume":"72","author":"P Pepe","year":"2008","unstructured":"Pepe P, Fraggetta F, Galia A, Grasso G, Piccolo S, Aragona F. Is quantitative histologic examination useful to predict nonorgan-confined prostate cancer when saturation biopsy is performed? Urology. 2008;72(6):1198\u20131202. doi:https:\/\/doi.org\/10.1016\/j.urology.2008.05.045","journal-title":"Urology"},{"issue":"6","key":"4998_CR45","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.clgc.2023.06.007","volume":"21","author":"P Pepe","year":"2023","unstructured":"Pepe P, Pennisi M. Targeted Biopsy in Men High Risk for Prostate Cancer: 68Ga-PSMA PET\/CT Versus mpMRI. Clin Genitourin Cancer. 2023;21(6):639\u2013642. doi:https:\/\/doi.org\/10.1016\/j.clgc.2023.06.007","journal-title":"Clin Genitourin Cancer"},{"issue":"3","key":"4998_CR46","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.21873\/invivo.13211","volume":"37","author":"P Pepe","year":"2023","unstructured":"Pepe P, Pepe L, Tamburo M, et al. 68Ga-PSMA PET\/CT and Prostate Cancer Diagnosis: Which SUVmax Value? Vivo Athens Greece. 2023;37(3):1318\u20131322. doi:https:\/\/doi.org\/10.21873\/invivo.13211","journal-title":"Vivo Athens Greece"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-04998-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-025-04998-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-04998-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:04:17Z","timestamp":1762880657000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-025-04998-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":46,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4998"],"URL":"https:\/\/doi.org\/10.1007\/s00261-025-04998-6","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"28 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}