{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:09:18Z","timestamp":1762880958711,"version":"3.45.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hainan Province Clinical Medical Center"},{"name":"Joint Program on Health Science & Technology Innovation of Hainan Province","award":["WSJK2024QN099","WSJK2024QN099","WSJK2024QN099"],"award-info":[{"award-number":["WSJK2024QN099","WSJK2024QN099","WSJK2024QN099"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"DOI":"10.1007\/s00261-025-05025-4","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T02:41:23Z","timestamp":1749004883000},"page":"5998-6007","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral adrenal heterogeneity in contrast-enhanced CT for differentiating nodule-negative primary aldosteronism"],"prefix":"10.1007","volume":"50","author":[{"given":"Guo","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinlei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanxi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"5025_CR1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1055\/a-1128-0421","volume":"52","author":"JS Lim","year":"2020","unstructured":"Lim JS, Rainey WE. The potential role of aldosterone-producing cell clusters in adrenal disease. Hormone and Metabolic Research 2020;52:427\u2013434","journal-title":"Hormone and Metabolic Research"},{"key":"5025_CR2","doi-asserted-by":"publisher","first-page":"bvad131","DOI":"10.1210\/jendso\/bvad131","volume":"7","author":"R Fu","year":"2023","unstructured":"Fu R, Walters K, Kaufman ML, Koc K, Baldwin A, Clay MR, et al. In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland. Journal of the Endocrine Society 2023;7:bvad131","journal-title":"Journal of the Endocrine Society"},{"key":"5025_CR3","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1210\/jc.2013-4146","volume":"99","author":"V Lim","year":"2014","unstructured":"Lim V, Guo Q, Grant CS, Thompson GB, Richards ML, Farley DR, et al. Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical cure of primary aldosteronism. The Journal of Clinical Endocrinology & Metabolism 2014;99:2712\u20132719","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"5025_CR4","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1148\/radiol.2015142413","volume":"277","author":"J-P Mailhot","year":"2015","unstructured":"Mailhot J-P, Traistaru M, Soulez G, Ladouceur M, Giroux M-F, Gilbert P, et al. Adrenal vein sampling in primary aldosteronism: sensitivity and specificity of basal adrenal vein to peripheral vein cortisol and aldosterone ratios to confirm catheterization of the adrenal vein. Radiology 2015;277:887\u2013894","journal-title":"Radiology"},{"key":"5025_CR5","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1210\/jc.2011-2830","volume":"97","author":"GP Rossi","year":"2012","unstructured":"Rossi GP, Barisa M, Allolio B, Auchus RJ, Amar L, Cohen D, et al. The Adrenal Vein Sampling International Study (AVIS) for identifying the major subtypes of primary aldosteronism. The Journal of clinical endocrinology 2012;97:1606\u20131614","journal-title":"The Journal of clinical endocrinology"},{"key":"5025_CR6","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1210\/jc.2015-4061","volume":"101","author":"JW Funder","year":"2016","unstructured":"Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism 2016;101:1889\u20131916","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"5025_CR7","doi-asserted-by":"publisher","first-page":"634879","DOI":"10.3389\/fonc.2021.634879","volume":"11","author":"K He","year":"2021","unstructured":"He K, Zhang Z, Wang Z, Wang Y, Wang Y, Zhang H, et al. A clinical-radiomic nomogram based on unenhanced computed tomography for predicting the risk of aldosterone-producing adenoma. Front Oncol 11: 634879. In, 2021","journal-title":"Front Oncol"},{"key":"5025_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s00330-023-10077-5","volume":"34","author":"Y Peng","year":"2024","unstructured":"Peng Y, Tang G, Sun M, Yu S, Cheng Y, Wang Y, et al. Feasibility of spectral CT\u2013derived extracellular volume fraction for differentiating aldosterone-producing from nonfunctioning adrenal nodules. European radiology 2024;34:50\u201359","journal-title":"European radiology"},{"key":"5025_CR9","first-page":"1182","volume":"102","author":"Y Yamazaki","year":"2017","unstructured":"Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, et al. Histopathological classification of cross-sectional image\u2013negative hyperaldosteronism. The Journal of Clinical Endocrinology & Metabolism 2017;102:1182\u20131192","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"5025_CR10","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00261-019-02048-6","volume":"45","author":"AC Morani","year":"2020","unstructured":"Morani AC, Jensen CT, Habra MA, Agrons MM, Menias CO, Wagner-Bartak NA, et al. Adrenocortical hyperplasia: a review of clinical presentation and imaging. Abdominal Radiology 2020;45:917\u2013927","journal-title":"Abdominal Radiology"},{"key":"5025_CR11","unstructured":"Velema M, Canu L, Dekkers T, Hermus A, Timmers H, Schultze Kool L, et al. Volumetric evaluation of CT images of adrenal glands in primary aldosteronism. Journal of endocrinological investigation 2021:1\u20138"},{"key":"5025_CR12","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/cen.13258","volume":"86","author":"C Degenhart","year":"2017","unstructured":"Degenhart C, Schneller J, Osswald A, Pallauf A, Riester A, Reiser MF, et al. Volumetric and densitometric evaluation of the adrenal glands in patients with primary aldosteronism. Clinical endocrinology 2017;86:325\u2013331","journal-title":"Clinical endocrinology"},{"key":"5025_CR13","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/HJH.0000000000002271","volume":"38","author":"S Li","year":"2020","unstructured":"Li S, Sun H, Ma L, Zhu Y, Xie W, Sun J, et al. Left-versus-right-adrenal-volume ratio as a screening index before adrenal venous sampling to identify unilateral primary aldosteronism patients. Journal of Hypertension 2020;38:347\u2013353","journal-title":"Journal of Hypertension"},{"key":"5025_CR14","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/eci.12746","volume":"47","author":"R Ladurner","year":"2017","unstructured":"Ladurner R, Sommerey S, Buechner S, Dietz A, Degenhart C, Hallfeldt K, et al. Accuracy of adrenal imaging and adrenal venous sampling in diagnosing unilateral primary aldosteronism. European journal of clinical investigation 2017;47:372\u2013377","journal-title":"European journal of clinical investigation"},{"key":"5025_CR15","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1055\/s-0043-122394","volume":"49","author":"K Omata","year":"2017","unstructured":"Omata K, Tomlins SA, Rainey WE. Aldosterone-producing cell clusters in normal and pathological states. Hormone and Metabolic Research 2017;49:951\u2013956","journal-title":"Hormone and Metabolic Research"},{"key":"5025_CR16","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1210\/jc.2009-2010","volume":"95","author":"K Nishimoto","year":"2010","unstructured":"Nishimoto K, Nakagawa K, Li D, Kosaka T, Oya M, Mikami S, et al. Adrenocortical zonation in humans under normal and pathological conditions. The Journal of Clinical Endocrinology & Metabolism 2010;95:2296\u20132305","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"5025_CR17","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.110.158543","volume":"56","author":"S Boulkroun","year":"2010","unstructured":"Boulkroun S, Samson-Couterie B, Dzib J-FG, Lefebvre H, Louiset E, Amar L, et al. Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism. Hypertension 2010;56:885\u2013892","journal-title":"Hypertension"},{"key":"5025_CR18","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1007\/s00261-016-1014-2","volume":"42","author":"S Leng","year":"2017","unstructured":"Leng S, Takahashi N, Gomez Cardona D, Kitajima K, McCollough B, Li Z, et al. Subjective and objective heterogeneity scores for differentiating small renal masses using contrast-enhanced CT. Abdominal Radiology 2017;42:1485\u20131492","journal-title":"Abdominal Radiology"},{"key":"5025_CR19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.2214\/AJR.15.15451","volume":"207","author":"MG Lubner","year":"2016","unstructured":"Lubner MG, Stabo N, Abel EJ, Del Rio AM, Pickhardt PJ. CT textural analysis of large primary renal cell carcinomas: pretreatment tumor heterogeneity correlates with histologic findings and clinical outcomes. American Journal of Roentgenology 2016;207:96\u2013105","journal-title":"American Journal of Roentgenology"},{"key":"5025_CR20","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s11604-022-01324-8","volume":"41","author":"G Tang","year":"2023","unstructured":"Tang G, Wang K, Peng Y, Sun M, Deng W, Guan J. Adrenal heterogeneity in the arterial phase of contrast-enhanced CT predicts prognosis in septic shock: comparison with hollow adrenal gland sign. Japanese Journal of Radiology 2023;41:92\u201397","journal-title":"Japanese Journal of Radiology"},{"key":"5025_CR21","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1210\/js.2017-00134","volume":"1","author":"K Omata","year":"2017","unstructured":"Omata K, Anand SK, Hovelson DH, Liu C-J, Yamazaki Y, Nakamura Y, et al. Aldosterone-producing cell clusters frequently harbor somatic mutations and accumulate with age in normal adrenals. Journal of the Endocrine Society 2017;1:787\u2013799","journal-title":"Journal of the Endocrine Society"},{"key":"5025_CR22","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1055\/s-0043-122238","volume":"49","author":"CE Gomez-Sanchez","year":"2017","unstructured":"Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA. Disordered CYP11B2 expression in primary aldosteronism. Hormone and Metabolic Research 2017;49:957\u2013962","journal-title":"Hormone and Metabolic Research"},{"key":"5025_CR23","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.118.11086","volume":"72","author":"K Omata","year":"2018","unstructured":"Omata K, Satoh F, Morimoto R, Ito S, Yamazaki Y, Nakamura Y, et al. Cellular and genetic causes of idiopathic hyperaldosteronism. Hypertension 2018;72:874\u2013880","journal-title":"Hypertension"},{"key":"5025_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fendo.2015.00095","volume":"6","author":"S Boulkroun","year":"2015","unstructured":"Boulkroun S, Fernandes-Rosa FL, Zennaro M-C. Molecular and cellular mechanisms of aldosterone producing adenoma development. Frontiers in endocrinology 2015;6:95","journal-title":"Frontiers in endocrinology"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-05025-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-025-05025-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-05025-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:04:49Z","timestamp":1762880689000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-025-05025-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5025"],"URL":"https:\/\/doi.org\/10.1007\/s00261-025-05025-4","relation":{},"ISSN":["2366-0058"],"issn-type":[{"type":"electronic","value":"2366-0058"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"27 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}