{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:55:43Z","timestamp":1793382943688,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"DOI":"10.1007\/s00261-025-05121-5","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:23:10Z","timestamp":1754036590000},"page":"1325-1331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radiofrequency ablation is safe in patients with hepatocellular carcinoma and thrombocytopenia"],"prefix":"10.1007","volume":"51","author":[{"given":"Songchi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"issue":"3","key":"5121_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","volume":"76","author":"M Reig","year":"2022","unstructured":"Reig M, Forner A, Rimola J, Ferrer-Fabrega J, Burrel M, Garcia-Criado A, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol. 2022;76(3):681\u201393. doi: https:\/\/doi.org\/10.1016\/j.jhep.2021.11.018.","journal-title":"J Hepatol"},{"issue":"5","key":"5121_CR2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3978\/j.issn.2304-3881.2014.09.07","volume":"3","author":"E Lahat","year":"2014","unstructured":"Lahat E, Eshkenazy R, Zendel A, Zakai BB, Maor M, Dreznik Y, et al. Complications after percutaneous ablation of liver tumors: a systematic review. Hepatobiliary Surg Nutr. 2014;3(5):317\u201323. doi: https:\/\/doi.org\/10.3978\/j.issn.2304-3881.2014.09.07.","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"5","key":"5121_CR3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/MCG.0b013e3181b7ed76","volume":"44","author":"E Goto","year":"2010","unstructured":"Goto E, Tateishi R, Shiina S, Masuzaki R, Enooku K, Sato T, et al. Hemorrhagic complications of percutaneous radiofrequency ablation for liver tumors. Journal of clinical gastroenterology. 2010;44(5):374\u201380. doi: https:\/\/doi.org\/10.1097\/MCG.0b013e3181b7ed76.","journal-title":"Journal of clinical gastroenterology"},{"issue":"2","key":"5121_CR4","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/hep4.1806","volume":"6","author":"V Ronca","year":"2022","unstructured":"Ronca V, Barabino M, Santambrogio R, Opocher E, Hodson J, Bertolini E, et al. Impact of Platelet Count on Perioperative Bleeding in Patients With Cirrhosis Undergoing Surgical Treatments of Liver Cancer. Hepatol Commun. 2022;6(2):423\u201334. doi: https:\/\/doi.org\/10.1002\/hep4.1806.","journal-title":"Hepatol Commun"},{"issue":"6","key":"5121_CR5","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/liv.13317","volume":"37","author":"M Peck-Radosavljevic","year":"2017","unstructured":"Peck-Radosavljevic M (2017) Thrombocytopenia in chronic liver disease. Liver International 37(6):778\u2013793. https:\/\/doi.org\/10.1111\/liv.13317","journal-title":"Liver International"},{"issue":"5","key":"5121_CR6","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.dld.2016.02.008","volume":"48","author":"A Andriulli","year":"2016","unstructured":"Andriulli A, Tripodi A, Angeli P, Senzolo M, Primignani M, Giannini EG, Riggio O, Colli A, Prati D, Sacerdoti D, Merkel C (2016) Hemostatic balance in patients with liver cirrhosis: report of a consensus conference. Digestive and Liver Disease 48(5):455\u2013467. https:\/\/doi.org\/10.1016\/j.dld.2016.02.008","journal-title":"Digestive and Liver Disease"},{"key":"5121_CR7","doi-asserted-by":"publisher","unstructured":"Editorial Board of Chinese Journal of Digestive Surgery. Chinese expert consensus on the clinical application of thrombopoietin receptor agonist in the perioperative period of liver cancer (2025 edition). Chin J Dig Surg. 2025; 24(1): 21\u201330. doi: https:\/\/doi.org\/10.3760\/cma.j.cn115610-20241216-00558.","DOI":"10.3760\/cma.j.cn115610-20241216-00558"},{"issue":"3","key":"5121_CR8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/bjh.14423","volume":"176","author":"LJ Estcourt","year":"2017","unstructured":"Estcourt LJ, Birchall J, Allard S, Bassey SJ, Hersey P, Kerr JP, et al. Guidelines for the use of platelet transfusions. British journal of haematology. 2017;176(3):365\u201394. doi: https:\/\/doi.org\/10.1111\/bjh.14423.","journal-title":"British journal of haematology"},{"issue":"1","key":"5121_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1179\/acb.2007.006","volume":"62","author":"A Bosly","year":"2007","unstructured":"Bosly A, Muylle L, Noens L, Pietersz R, Heims D, H\u00fcbner R, et al. Guidelines for the transfusion of platelets. Acta clinica Belgica. 2007;62(1):36\u201347. doi: https:\/\/doi.org\/10.1179\/acb.2007.006.","journal-title":"Acta clinica Belgica"},{"issue":"5","key":"5121_CR10","doi-asserted-by":"publisher","first-page":"1615-27 e1","DOI":"10.1053\/j.gastro.2021.08.015","volume":"161","author":"RS O\u2019Shea","year":"2021","unstructured":"O\u2019Shea RS, Davitkov P, Ko CW, Rajasekhar A, Su GL, Sultan S, et al. AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis. Gastroenterology. 2021;161(5):1615-27 e1. doi: https:\/\/doi.org\/10.1053\/j.gastro.2021.08.015.","journal-title":"Gastroenterology"},{"issue":"8","key":"5121_CR11","doi-asserted-by":"publisher","first-page":"1168-84.e1","DOI":"10.1016\/j.jvir.2019.04.017","volume":"30","author":"IJ Patel","year":"2019","unstructured":"Patel IJ, Rahim S, Davidson JC, Hanks SE, Tam AL, Walker TG, et al. Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions\u2014Part II: Recommendations. Journal of Vascular and Interventional Radiology. 2019;30(8):1168-84.e1. doi: https:\/\/doi.org\/10.1016\/j.jvir.2019.04.017.","journal-title":"Journal of Vascular and Interventional Radiology"},{"issue":"2","key":"5121_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MBC.0000000000000561","volume":"28","author":"H Baccouche","year":"2017","unstructured":"Baccouche H, Labidi A, Fekih M, Mahjoub S, Kaabi H, Hmida S, et al. Haemostatic balance in cirrhosis. Blood Coagul Fibrinolysis. 2017;28(2):139\u201344. doi: https:\/\/doi.org\/10.1097\/MBC.0000000000000561.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"5","key":"5121_CR13","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.jhep.2016.06.002","volume":"65","author":"G Kalambokis","year":"2016","unstructured":"Kalambokis G, Oikonomou A, Christou L, Kolaitis N, Tsianos E, Christodoulou D et al (2016) von Willebrand factor and procoagulant imbalance predict outcome in patients with cirrhosis and thrombocytopenia. Journal of Hepatology 65(5):921\u20138. https:\/\/doi.org\/10.1016\/j.jhep.2016.06.002","journal-title":"Journal of Hepatology"},{"issue":"02","key":"5121_CR14","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1055\/s-0038-1676954","volume":"119","author":"S Bos","year":"2019","unstructured":"Bos S, van den Boom B, Kamphuisen PW, Adelmeijer J, Blokzijl H, Schreuder T, Lisman T (2019) Haemostatic profiles are similar across all aetiologies of cirrhosis. Thrombosis and haemostasis 119(02):246\u2013253. https:\/\/doi.org\/10.1055\/s-0038-1676954","journal-title":"Thrombosis and haemostasis"},{"issue":"1","key":"5121_CR15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1538-7836.2009.03678.x","volume":"8","author":"S Schulman","year":"2010","unstructured":"Schulman S, Angeras U, Bergqvist D, Eriksson B, Lassen MR, Fisher W, et al. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients. J Thromb Haemost. 2010;8(1):202\u20134. doi: https:\/\/doi.org\/10.1111\/j.1538-7836.2009.03678.x.","journal-title":"J Thromb Haemost"},{"issue":"8","key":"5121_CR16","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.crad.2017.03.001","volume":"72","author":"JG Park","year":"2017","unstructured":"Park JG, Park SY, Tak WY, Kweon YO, Jang SY, Lee YR, et al. Early complications after percutaneous radiofrequency ablation for hepatocellular carcinoma: an analysis of 1,843 ablations in 1,211 patients in a single centre: experience over 10 years. Clinical radiology. 2017;72(8):692.e9-e15. https:\/\/doi.org\/10.1016\/j.crad.2017.03.001","journal-title":"Clinical radiology"},{"issue":"1","key":"5121_CR17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-0030-1247132","volume":"30","author":"R Lencioni","year":"2010","unstructured":"Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Seminars in liver disease. 2010;30(1):52\u201360. doi: https:\/\/doi.org\/10.1055\/s-0030-1247132.","journal-title":"Seminars in liver disease"},{"issue":"3","key":"5121_CR18","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/liv.12038","volume":"33","author":"A Tripodi","year":"2013","unstructured":"Tripodi A, Primignani M, Chantarangkul V, Lemma L, Jovani M, Rebulla P et al (2013) Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion. Liver International 33(3):362\u20137. https:\/\/doi.org\/10.1111\/liv.12038","journal-title":"Liver International\u00a0"},{"issue":"1","key":"5121_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1053\/j.gastro.2019.03.070","volume":"157","author":"JG O\u2019Leary","year":"2019","unstructured":"O\u2019Leary JG, Greenberg CS, Patton HM, Caldwell SH. AGA Clinical Practice Update: Coagulation in Cirrhosis. Gastroenterology. 2019;157(1):34\u201343 e1. doi: https:\/\/doi.org\/10.1053\/j.gastro.2019.03.070.","journal-title":"Gastroenterology"},{"issue":"3","key":"5121_CR20","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1053\/j.gastro.2018.05.025","volume":"155","author":"N Terrault","year":"2018","unstructured":"Terrault N, Chen YC, Izumi N, Kayali Z, Mitrut P, Tak WY, et al. Avatrombopag Before Procedures Reduces Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia. Gastroenterology. 2018;155(3):705\u201318. doi: https:\/\/doi.org\/10.1053\/j.gastro.2018.05.025.","journal-title":"Gastroenterology"},{"issue":"8","key":"5121_CR21","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1056\/NEJMoa1110709","volume":"367","author":"NH Afdhal","year":"2012","unstructured":"Afdhal NH, Giannini EG, Tayyab G, Mohsin A, Lee JW, Andriulli A, et al. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. The New England journal of medicine. 2012;367(8):716\u201324. doi: https:\/\/doi.org\/10.1056\/NEJMoa1110709.","journal-title":"The New England journal of medicine"},{"issue":"12","key":"5121_CR22","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1111\/jth.14295","volume":"16","author":"AD Michelson","year":"2018","unstructured":"Michelson AD, Smolensky Koganov E, Forde EE, Carmichael SL, Frelinger AL, 3rd. Avatrombopag increases platelet count but not platelet activation in patients with thrombocytopenia resulting from liver disease. J Thromb Haemost. 2018;16(12):2515\u20139. doi: https:\/\/doi.org\/10.1111\/jth.14295.","journal-title":"J Thromb Haemost"},{"issue":"1","key":"5121_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.dld.2018.06.005","volume":"51","author":"L Loffredo","year":"2019","unstructured":"Loffredo L, Violi F. Thrombopoietin receptor agonists and risk of portal vein thrombosis in patients with liver disease and thrombocytopenia: A meta-analysis. Dig Liver Dis. 2019;51(1):24\u20137. doi: https:\/\/doi.org\/10.1016\/j.dld.2018.06.005.","journal-title":"Dig Liver Dis"},{"issue":"6","key":"5121_CR24","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1160\/th14-10-0892","volume":"113","author":"X Qi","year":"2015","unstructured":"Qi X, De Stefano V, Guo X, Fan D. Thrombopoietin receptor agonists significantly increase the risk of portal vein thrombosis in liver diseases: Meta-analysis of RCTs. Thrombosis and haemostasis. 2015;113(6):1378\u201380. doi: https:\/\/doi.org\/10.1160\/th14-10-0892.","journal-title":"Thrombosis and haemostasis"},{"issue":"1","key":"5121_CR25","doi-asserted-by":"publisher","first-page":"28350","DOI":"10.1038\/s41598-024-79416-w","volume":"14","author":"F Zhao","year":"2024","unstructured":"Zhao, F., Zhang, T., Yang, Q., Zhang, X., Yang, F., & Qian, N. Safety of local thermal ablation in hepatocellular carcinoma patients with cirrhosis and severe thrombocytopenia. Scientific reports. 2024; 14(1): 28350. doi: https:\/\/doi.org\/10.1038\/s41598-024-79416-w.","journal-title":"Scientific reports"},{"issue":"5","key":"5121_CR26","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.jhep.2018.12.027","volume":"70","author":"A Doyle","year":"2019","unstructured":"Doyle A, Gorgen A, Muaddi H, Aravinthan AD, Issachar A, Mironov O, et al. Outcomes of radiofrequency ablation as first-line therapy for hepatocellular carcinoma less than 3\u00a0cm in potentially transplantable patients. J Hepatol. 2019;70(5):866\u201373. doi: https:\/\/doi.org\/10.1016\/j.jhep.2018.12.027.","journal-title":"J Hepatol"},{"issue":"1","key":"5121_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000510909","volume":"10","author":"DH Lee","year":"2021","unstructured":"Lee DH, Kim JW, Lee JM, Kim JM, Lee MW, Rhim H, et al. Laparoscopic Liver Resection versus Percutaneous Radiofrequency Ablation for Small Single Nodular Hepatocellular Carcinoma: Comparison of Treatment Outcomes. Liver Cancer. 2021;10(1):25\u201337. doi: https:\/\/doi.org\/10.1159\/000510909.","journal-title":"Liver Cancer"},{"issue":"4","key":"5121_CR28","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.jhep.2012.05.007","volume":"57","author":"K Feng","year":"2012","unstructured":"Feng K, Yan J, Li X, Xia F, Ma K, Wang S, et al. A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. J Hepatol. 2012;57(4):794\u2013802. doi: https:\/\/doi.org\/10.1016\/j.jhep.2012.05.007.","journal-title":"J Hepatol"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-05121-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-025-05121-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-05121-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:01:47Z","timestamp":1773111707000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-025-05121-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["5121"],"URL":"https:\/\/doi.org\/10.1007\/s00261-025-05121-5","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}