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Contrast-enhanced CT images were reconstructed using conventional IR and vendor-neutral ClariACE. Three abdominal radiologists independently assessed image quality (based on 8 parameters: tumor conspicuity, tumor margin, image noise, sharpness of the main pancreatic duct, arterial depiction, venous depiction, plasticity and overall image quality) and determined tumor resectability with confidence levels. Quantitative analysis included aortic and portal venous attenuation measurements and pancreas-to-tumor contrast-to-noise ratio (CNR). Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUC) with DeLong\u2019s test. Sensitivity, specificity, accuracy, and reader confidence were compared using McNemar\u2019s test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DLR demonstrated significantly superior vessel enhancement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and improved CNR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) versus conventional IR. Two readers consistently rated DLR images higher across all qualitative categories (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) except plasticity, while the third reader favored DLR in five of eight parameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 to 0.020). However, all readers noted increased artificial appearance in DLR images (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Despite image quality improvements, no significant differences were observed in resectability assessment accuracy (62.3%-65.8%), AUC values (0.485\u20130.520), or high-confidence diagnosis rates between reconstruction methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although deep learning-based combined noise reduction and contrast enhancement reconstruction significantly improved quantitative and subjective image quality metrics, it did not enhance diagnostic accuracy for predicting R0 resectability in post-neoadjuvant pancreatic cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00261-025-05271-6","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:49:37Z","timestamp":1762256977000},"page":"2485-2498","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep learning-based combined noise reduction and contrast enhancement for post-neoadjuvant pancreatic cancer CT: does improved image quality translate to better resectability assessment?"],"prefix":"10.1007","volume":"51","author":[{"given":"Seok Jin","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Kyung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongin","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Jin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghoan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"5271_CR1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1148\/radiol.2018171670","volume":"287","author":"M Zins","year":"2018","unstructured":"M. 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The funding organization had no role in the study design, data collection, analysis, interpretation of results, or manuscript preparation.S.J.H., S.K.J., J.Y., J.H.Y., H.K., J.H.P., J.M.L. received salary support from this grant. The other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}