{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:05:53Z","timestamp":1784610353663,"version":"3.55.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK132346"],"award-info":[{"award-number":["R01DK132346"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Magnetic resonance imaging (MRI) with secretin stimulation allows non-invasive assessment of pancreatic secretion in vivo. Software (PFTquant) can facilitate quantification of secretory response. Our objective was to quantify secretory response for a clinical sample of pediatric patients and compare quantitative to qualitative assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred one examinations of 169 patients (&lt;\u200921 years of age) were processed using PFTquant and manually refined by human observers. Fluid volumes were characterized as normal or abnormal based on 5th percentile values by body surface area (BSA) and age and were compared to qualitative assessment of secretory response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean patient age was 12.1\u2009\u00b1\u20094.9 (0\u201320) years and 106 (52.7%) were female. The most common diagnoses were acute recurrent (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954, 26.9%), chronic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953, 26.4%), and acute (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929, 14.4%) pancreatitis. Based on human-refined segmentation, secretory response was abnormal in 70 (34.8%; by BSA) and 62 (30.8%; by age) patients, including 48.3% (14\/29) of patients with acute pancreatitis. Clinical reports characterized secretory response as qualitatively abnormal in 26\/201 (12.9%) examinations. Compared to quantitative analysis, qualitative assessment was falsely positive in 12 cases and falsely negative in 50 (BSA) or 55 (age) cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a clinical sample of pediatric and young adult patients, abnormal pancreatic secretory response was present in 30.8 to 34.8% of patients and was most common in patients with acute pancreatitis. Quantiative assessment identifies more patients with abnormal secretory response than qualitative assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00261-025-05364-2","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:23:19Z","timestamp":1768285399000},"page":"3821-3829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of automated pancreatic secretory response measurement in a cohort of pediatric patients"],"prefix":"10.1007","volume":"51","author":[{"given":"Alexandra O","family":"Glenn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Dudley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu-El-Haija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-4054","authenticated-orcid":false,"given":"Andrew T","family":"Trout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"issue":"2","key":"5364_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1148\/radiology.203.2.9114101","volume":"203","author":"C Matos","year":"1997","unstructured":"Matos C, Metens T, Devi\u00e8re J, Nicaise N, Braud\u00e9 P, Van Yperen G, Cremer M, Struyven J (1997) Pancreatic duct: morphologic and functional evaluation with dynamic MR pancreatography after secretin stimulation. Radiology 203 (2):435\u2013441. doi:https:\/\/doi.org\/10.1148\/radiology.203.2.9114101","journal-title":"Radiology"},{"issue":"4","key":"5364_CR2","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2214\/ajr.19.21798","volume":"214","author":"Y Li","year":"2020","unstructured":"Li Y, Dillman JR, Anton CG, Crotty EJ, Smith EA, Abu-El-Haija M, Trout AT (2020) Secretin Improves Visualization of Nondilated Pancreatic Ducts in Children Undergoing MRCP. AJR Am J Roentgenol 214 (4):917\u2013922. doi:https:\/\/doi.org\/10.2214\/ajr.19.21798","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"5364_CR3","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.pan.2023.04.005","volume":"23","author":"M Saad","year":"2023","unstructured":"Saad M, Vitale DS, Lin TK, Thapaliya S, Zhou Y, Zhang B, Trout AT, Abu-El-Haija M (2023) Image or scope: Magnetic resonance imaging and endoscopic testing for exocrine and endocrine pancreatic insufficiency in children. Pancreatology 23 (4):437\u2013443. doi:https:\/\/doi.org\/10.1016\/j.pan.2023.04.005","journal-title":"Pancreatology"},{"issue":"41","key":"5364_CR4","doi-asserted-by":"publisher","first-page":"7177","DOI":"10.3748\/wjg.v19.i41.7177","volume":"19","author":"Y Bian","year":"2013","unstructured":"Bian Y, Wang L, Chen C, Lu JP, Fan JB, Chen SY, Zhao BH (2013) Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP. World J Gastroenterol 19 (41):7177\u20137182. doi:https:\/\/doi.org\/10.3748\/wjg.v19.i41.7177","journal-title":"World J Gastroenterol"},{"issue":"2","key":"5364_CR5","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1148\/radiology.215.2.r00ma10358","volume":"215","author":"O Cappeliez","year":"2000","unstructured":"Cappeliez O, Delhaye M, Devi\u00e8re J, Le Moine O, Metens T, Nicaise N, Cremer M, Stryuven J, Matos C (2000) Chronic pancreatitis: evaluation of pancreatic exocrine function with MR pancreatography after secretin stimulation. Radiology 215 (2):358\u2013364. doi:https:\/\/doi.org\/10.1148\/radiology.215.2.r00ma10358","journal-title":"Radiology"},{"issue":"2","key":"5364_CR6","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/jmri.24167","volume":"39","author":"GK Wathle","year":"2014","unstructured":"Wathle GK, Tjora E, Ersland L, Dimcevski G, Salvesen \u00d8 O, Molven A, Nj\u00f8lstad PR, Haldorsen IS (2014) Assessment of exocrine pancreatic function by secretin-stimulated magnetic resonance cholangiopancreaticography and diffusion-weighted imaging in healthy controls. J Magn Reson Imaging 39 (2):448\u2013454. doi:https:\/\/doi.org\/10.1002\/jmri.24167","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"5364_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/00006676-200110000-00015","volume":"23","author":"L Czako","year":"2001","unstructured":"Czako L, Endes J, Takacs T, Boda K, Lonovics J (2001) Evaluation of pancreatic exocrine function by secretin-enhanced magnetic resonance cholangiopancreatography. Pancreas 23 (3):323\u2013328. doi:https:\/\/doi.org\/10.1097\/00006676-200110000-00015","journal-title":"Pancreas"},{"issue":"Suppl 1","key":"5364_CR8","doi-asserted-by":"publisher","first-page":"S27-s42","DOI":"10.1002\/ncp.10388","volume":"34","author":"S Sankararaman","year":"2019","unstructured":"Sankararaman S, Schindler T, Sferra TJ (2019) Management of Exocrine Pancreatic Insufficiency in Children. Nutr Clin Pract 34 Suppl 1:S27-s42. doi:https:\/\/doi.org\/10.1002\/ncp.10388","journal-title":"Nutr Clin Pract"},{"issue":"5","key":"5364_CR9","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1053\/j.gastro.2023.07.007","volume":"165","author":"DC Whitcomb","year":"2023","unstructured":"Whitcomb DC, Buchner AM, Forsmark CE (2023) AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review. Gastroenterology 165 (5):1292\u20131301. doi:https:\/\/doi.org\/10.1053\/j.gastro.2023.07.007","journal-title":"Gastroenterology"},{"issue":"9","key":"5364_CR10","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1038\/s41395-018-0190-9","volume":"113","author":"AT Trout","year":"2018","unstructured":"Trout AT, Serai SD, Fei L, Sun Q, Abu-El-Haija M (2018) Prospective Assessment of Normal Pancreatic Secretory Function Measured by MRI in a Cohort of Healthy Children. Am J Gastroenterol 113 (9):1385. doi:https:\/\/doi.org\/10.1038\/s41395-018-0190-9","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"5364_CR11","doi-asserted-by":"publisher","first-page":"102","DOI":"10.2214\/ajr.12.10271","volume":"202","author":"B Mensel","year":"2014","unstructured":"Mensel B, Messner P, Mayerle J, Fluhr G, V\u00f6lzke H, Lerch MM, Ittermann T, K\u00fchn JP (2014) Secretin-stimulated MRCP in volunteers: assessment of safety, duct visualization, and pancreatic exocrine function. AJR Am J Roentgenol 202 (1):102\u2013108. doi:https:\/\/doi.org\/10.2214\/ajr.12.10271","journal-title":"AJR Am J Roentgenol"},{"key":"5364_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jpeds.2017.06.031","volume":"188","author":"AT Trout","year":"2017","unstructured":"Trout AT, Wallihan DB, Serai S, Abu-El-Haija M (2017) Secretin-Enhanced Magnetic Resonance Cholangiopancreatography for Assessing Pancreatic Secretory Function in Children. J Pediatr 188:186\u2013191. doi:https:\/\/doi.org\/10.1016\/j.jpeds.2017.06.031","journal-title":"J Pediatr"},{"issue":"5","key":"5364_CR13","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.2214\/AJR.20.24857","volume":"216","author":"J Swensson","year":"2021","unstructured":"Swensson J, Zaheer A, Conwell D, Sandrasegaran K, Manfredi R, Tirkes T (2021) Secretin-Enhanced MRCP: How and Why-AJR Expert Panel Narrative Review. AJR Am J Roentgenol 216 (5):1139\u20131149. doi:https:\/\/doi.org\/10.2214\/AJR.20.24857","journal-title":"AJR Am J Roentgenol"},{"issue":"7","key":"5364_CR14","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1007\/s00261-024-04442-1","volume":"49","author":"JA Dudley","year":"2024","unstructured":"Dudley JA, Ata NA, Murdock KE, Vitale DS, Abu-El-Haija M, Trout AT (2024) Semi-automated software improves interrater reliability and reduces processing time of magnetic resonance imaging-based exocrine pancreatic assessments in pediatric patients. Abdom Radiol (NY) 49 (7):2408\u20132415. doi:https:\/\/doi.org\/10.1007\/s00261-024-04442-1","journal-title":"Abdom Radiol (NY)"},{"issue":"1","key":"5364_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/s0022-3476(78)80601-5","volume":"93","author":"GB Haycock","year":"1978","unstructured":"Haycock GB, Schwartz GJ, Wisotsky DH (1978) Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr 93 (1):62\u201366. doi:https:\/\/doi.org\/10.1016\/s0022-3476(78)80601-5","journal-title":"J Pediatr"},{"issue":"7244","key":"5364_CR16","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","volume":"320","author":"TJ Cole","year":"2000","unstructured":"Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. Bmj 320 (7244):1240\u20131243. doi:https:\/\/doi.org\/10.1136\/bmj.320.7244.1240","journal-title":"Bmj"},{"issue":"2","key":"5364_CR17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","volume":"15","author":"TK Koo","year":"2016","unstructured":"Koo TK, Li MY (2016) A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. J Chiropr Med 15 (2):155\u2013163. doi:https:\/\/doi.org\/10.1016\/j.jcm.2016.02.012","journal-title":"J Chiropr Med"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-05364-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-025-05364-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-025-05364-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:46:17Z","timestamp":1784609177000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-025-05364-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["5364"],"URL":"https:\/\/doi.org\/10.1007\/s00261-025-05364-2","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"assertion":[{"value":"8 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. Trout previously consulted for GE Healthcare and receives unrelated research support from GE Healthcare, Perspectum, and Siemens Healthineers.No other conflicts of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}