{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:33:46Z","timestamp":1790444026350,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Abdom Radiol"],"DOI":"10.1007\/s00261-026-05447-8","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:40:04Z","timestamp":1774348804000},"page":"5269-5278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From conventional to next-generation diagnostics in cystic echinococcosis: integrating serology, ultrasonography, and molecular tools: a review"],"prefix":"10.1007","volume":"51","author":[{"given":"Mitra","family":"Salehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Nastaran","family":"Asadzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Gholamrezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrzad","family":"Havakhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Firouzeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"5447_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","volume":"114","author":"E Brunetti","year":"2010","unstructured":"Brunetti E, Kern P, Vuitton DA (2010) Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114:1\u201316. https:\/\/doi.org\/10.1016\/j.actatropica.2009.11.001","journal-title":"Acta Trop"},{"key":"5447_CR2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/08839115211014219","volume":"36","author":"N Firouzeh","year":"2021","unstructured":"Firouzeh N, Eslaminejad T, Shafiei R, et al (2021) Lethal in vitro effects of optimized chitosan nanoparticles against protoscoleces of Echinococcus granulosus. J Bioact Compat Polym 36:237\u2013248. https:\/\/doi.org\/10.1177\/08839115211014219","journal-title":"J Bioact Compat Polym"},{"key":"5447_CR3","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","volume":"362","author":"DP McManus","year":"2003","unstructured":"McManus DP, Zhang W, Li J, Bartley PB (2003) Echinococcosis. Lancet 362:1295\u20131304","journal-title":"Lancet"},{"key":"5447_CR4","unstructured":"Eckert J, Gemmell MA, Meslin F-X, et al (2001) WHO\/OIE manual on echinococcosis in humans and animals: a public health problem of global concern. World organisation for animal health"},{"key":"5447_CR5","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1016\/S1473-3099(22)00638-7","volume":"23","author":"A Casulli","year":"2023","unstructured":"Casulli A, Abela-Ridder B, Petrone D, et al (2023) Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project. Lancet Infect Dis 23:e95\u2013e107","journal-title":"Lancet Infect Dis"},{"key":"5447_CR6","doi-asserted-by":"publisher","first-page":"551","DOI":"10.12991\/marupj.319204","volume":"21","author":"A Keyhani","year":"2017","unstructured":"Keyhani A, Kareshk AT, Oliaei RT, Mahmoudvand H (2017) Protoscolicidal effects and acute toxicity of essential oil and methanolic extract of Cuminum cyminum seeds. Marmara Pharm J 21:551\u2013557","journal-title":"Marmara Pharm J"},{"key":"5447_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0034-5288(03)00006-7","volume":"74","author":"PR Torgerson","year":"2003","unstructured":"Torgerson PR, Budke CM (2003) Echinococcosis\u2013an international public health challenge. Res Vet Sci 74:191\u2013202","journal-title":"Res Vet Sci"},{"key":"5447_CR8","doi-asserted-by":"publisher","first-page":"e0009370","DOI":"10.1371\/journal.pntd.0009370","volume":"15","author":"F Tamarozzi","year":"2021","unstructured":"Tamarozzi F, Silva R, Fittipaldo VA, et al (2021) Serology for the diagnosis of human hepatic cystic echinococcosis and its relation with cyst staging: A systematic review of the literature with meta-analysis. PLoS Negl Trop Dis 15:e0009370. https:\/\/doi.org\/10.1371\/journal.pntd.0009370","journal-title":"PLoS Negl Trop Dis"},{"key":"5447_CR9","doi-asserted-by":"crossref","unstructured":"Goodfellow SM, Karnaze A, Kim H, et al (2025) Diagnosis of cystic echinococcosis within a pediatric hospital setting. ASM Case Reports e00040-25","DOI":"10.1128\/asmcr.00040-25"},{"key":"5447_CR10","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1002\/jum.16452","volume":"43","author":"R Shafiei","year":"2024","unstructured":"Shafiei R, Mohajerzadeh MS, Masomi HFA, et al (2024) Discordance Therapeutic Protocol of Cystic Echinococcosis With WHO Guideline: A Descriptive Study Based on Liver Ultra-Sonographic Data in North Khorasan Province, Northeastern of Iran. J Ultrasound Med 43:1279\u20131287","journal-title":"J Ultrasound Med"},{"key":"5447_CR11","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1017\/S0022149X2400021X","volume":"98","author":"F Tamarozzi","year":"2024","unstructured":"Tamarozzi F (2024) Ultrasound diagnosis of cystic echinococcosis: updates and implications for clinical management. J Helminthol 98:e34","journal-title":"J Helminthol"},{"key":"5447_CR12","doi-asserted-by":"publisher","first-page":"474368","DOI":"10.1155\/2009\/474368","volume":"2009","author":"A Siracusano","year":"2009","unstructured":"Siracusano A, Teggi A, Ortona E (2009) Human cystic echinococcosis: old problems and new perspectives. Interdiscip Perspect Infect Dis 2009:474368","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"5447_CR13","doi-asserted-by":"publisher","first-page":"1273870","DOI":"10.3389\/fmicb.2023.1273870","volume":"14","author":"Y Meng","year":"2023","unstructured":"Meng Y, Ren Q, Xiao J, et al (2023) Progress of research on the diagnosis and treatment of bone cystic echinococcosis. Front Microbiol 14:1273870","journal-title":"Front Microbiol"},{"key":"5447_CR14","doi-asserted-by":"crossref","unstructured":"Stojkovic M, Mickan C, Weber TF, Junghanss T (2015) Pitfalls in diagnosis and treatment of alveolar echinococcosis: a sentinel case series. BMJ open Gastroenterol 2:","DOI":"10.1136\/bmjgast-2015-000036"},{"key":"5447_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/tropicalmed9020036","volume":"9","author":"M-O Hogea","year":"2024","unstructured":"Hogea M-O, Ciomaga B-F, Muntean M-M, et al (2024) Cystic echinococcosis in the early 2020s: a review. Trop Med Infect Dis 9:36","journal-title":"Trop Med Infect Dis"},{"key":"5447_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.4103\/2229-5070.105174","volume":"2","author":"S Parija","year":"2012","unstructured":"Parija S, Giri S (2012) A review on diagnostic and preventive aspects of cystic echinococcosis and human cysticercosis. Trop Parasitol 2:99. https:\/\/doi.org\/10.4103\/2229-5070.105174","journal-title":"Trop Parasitol"},{"key":"5447_CR17","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","volume":"17","author":"J Eckert","year":"2004","unstructured":"Eckert J, Deplazes P (2004) Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern. Clin Microbiol Rev 17:107\u2013135. https:\/\/doi.org\/10.1128\/CMR.17.1.107-135.2004","journal-title":"Clin Microbiol Rev"},{"key":"5447_CR18","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1007\/s00436-021-07262-0","volume":"120","author":"CR Yangdan","year":"2021","unstructured":"Yangdan CR, Wang C, Zhang LQ, et al (2021) Recent advances in ultrasound in the diagnosis and evaluation of the activity of hepatic alveolar echinococcosis. Parasitol Res 120:3077\u20133082. https:\/\/doi.org\/10.1007\/s00436-021-07262-0","journal-title":"Parasitol Res"},{"key":"5447_CR19","unstructured":"Organization WH (2017) Meeting of the WHO Informal Working Group on Echinococcosis (WHO-IWGE): WHO Headquarters, Geneva, Switzerland, 15\u201316 December 2016. World Health Organization"},{"key":"5447_CR20","doi-asserted-by":"crossref","unstructured":"Stojkovic M, M\u00fcller J, Junghanss T, Weber TF (2018) Radiological diagnoses in the context of emigration: infectious diseases. In: R\u00f6Fo-Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren. \u00a9 Georg Thieme Verlag KG, pp 121\u2013133","DOI":"10.1055\/s-0043-120764"},{"key":"5447_CR21","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1136\/gut.10.11.904","volume":"10","author":"CF McCarthy","year":"1969","unstructured":"McCarthy CF, Wells PNT, Ross FGM, Read AEA (1969) The use of ultrasound in the diagnosis of cystic lesions of the liver and upper abdomen and in the detection of ascites. Gut 10:904\u2013912","journal-title":"Gut"},{"key":"5447_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13071-023-05731-2","volume":"16","author":"X Zhang","year":"2023","unstructured":"Zhang X, Suolang L, Ren Y, et al (2023) Can contrast-enhanced ultrasound differentiate the type of hepatic echinococcosis: cystic echinococcosis or alveolar echinococcosis? Parasit Vectors 16:131","journal-title":"Parasit Vectors"},{"key":"5447_CR23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.25122\/jml-2018-0045","volume":"11","author":"C Botezatu","year":"2018","unstructured":"Botezatu C, Mastalier B, Patrascu T (2018) Hepatic hydatid cyst - diagnose and treatment algorithm. J Med Life 11:203\u2013209. https:\/\/doi.org\/10.25122\/jml-2018-0045","journal-title":"J Med Life"},{"key":"5447_CR24","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1007\/s11686-024-00840-z","volume":"69","author":"S Erganis","year":"2024","unstructured":"Erganis S, Sarzhanov F, Al FD, Ca\u011flar K (2024) Comparison of methods in the serologic diagnosis of cystic echinococcosis. Acta Parasitol 69:1122\u20131131","journal-title":"Acta Parasitol"},{"key":"5447_CR25","doi-asserted-by":"publisher","first-page":"462","DOI":"10.4269\/ajtmh.1999.60.462","volume":"60","author":"MA Shambesh","year":"1999","unstructured":"Shambesh MA, Craig PS, Macpherson CNL, et al (1999) An extensive ultrasound and serologic study to investigate the prevalence of human cystic echinococcosis in Northern Libya. Am J Trop Med Hyg 60:462\u2013468. https:\/\/doi.org\/10.4269\/ajtmh.1999.60.462","journal-title":"Am J Trop Med Hyg"},{"key":"5447_CR26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/bs.apar.2016.09.003","volume":"96","author":"M Siles-Lucas","year":"2017","unstructured":"Siles-Lucas M, Casulli A, Conraths FJ, M\u00fcller N (2017) Laboratory diagnosis of Echinococcus spp. in human patients and infected animals. Adv Parasitol 96:159\u2013257","journal-title":"Adv Parasitol"},{"key":"5447_CR27","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3233\/CH-189310","volume":"70","author":"V Schwarze","year":"2019","unstructured":"Schwarze V, Mueller-Peltzer K, Negr\u00e3o de Figueiredo G, et al (2019) The use of contrast-enhanced ultrasound (CEUS) for the diagnostic evaluation of hepatic echinococcosis. Clin Hemorheol Microcirc 70:449\u2013455","journal-title":"Clin Hemorheol Microcirc"},{"key":"5447_CR28","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.7150\/thno.18650","volume":"7","author":"RMS Sigrist","year":"2017","unstructured":"Sigrist RMS, Liau J, El Kaffas A, et al (2017) Ultrasound elastography: review of techniques and clinical applications. Theranostics 7:1303","journal-title":"Theranostics"},{"key":"5447_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4103\/jmu.jmu_134_23","volume":"33","author":"E Karatay","year":"2025","unstructured":"Karatay E, Turkoglu O, Eren A, Javadov M (2025) Evaluation of Usability and Efficacy of Strain Elastography Method Concurrently with Preoperative Ultrasonography in Cases of Hydatid Cyst. J Med Ultrasound 33:23\u201328","journal-title":"J Med Ultrasound"},{"key":"5447_CR30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.5152\/tjg.2014.7112","volume":"25","author":"J Wuestenberg","year":"2014","unstructured":"Wuestenberg J, Gruener B, Oeztuerk S, et al (2014) Diagnostics in cystic echinococcosis: serology versus ultrasonography. Turkish J Gastroenterol 25:398\u2013404","journal-title":"Turkish J Gastroenterol"},{"key":"5447_CR31","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3390\/pathogens11030348","volume":"11","author":"N Eberhardt","year":"2022","unstructured":"Eberhardt N, Peters L, Kapp-Schwoerer S, et al (2022) 18F-FDG-PET\/MR in alveolar echinococcosis: multiparametric imaging in a real-world setting. Pathogens 11:348","journal-title":"Pathogens"},{"key":"5447_CR32","doi-asserted-by":"publisher","first-page":"e0013833","DOI":"10.1371\/journal.pntd.0013833","volume":"19","author":"C Stocchero","year":"2025","unstructured":"Stocchero C, Manciulli T, Zanon A, et al (2025) Detection of Echinococcus granulosus sensu lato microRNAs in cystic echinococcosis patients: An exploratory study using quantitative PCR and digital PCR. PLoS Negl Trop Dis 19:e0013833","journal-title":"PLoS Negl Trop Dis"},{"key":"5447_CR33","doi-asserted-by":"crossref","unstructured":"Ereqat S, Al-Jawabreh A, Al-Jawabreh H, Nasereddin A (2024) Use of the EmsB microsatellite-based next generation sequencing for genotyping of Echinococcus granulosus sensu lato in hydatid cyst tissue samples from animals and humans","DOI":"10.14411\/fp.2024.014"},{"key":"5447_CR34","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/tropicalmed9070163","volume":"9","author":"B Bold","year":"2024","unstructured":"Bold B, Schindler C, Narankhuu U, et al (2024) The diagnostic challenge of cystic echinococcosis in humans: First assessment of underreporting rates in Mongolia. Trop Med Infect Dis 9:163","journal-title":"Trop Med Infect Dis"}],"container-title":["Abdominal Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-026-05447-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00261-026-05447-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00261-026-05447-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:13:54Z","timestamp":1789452834000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00261-026-05447-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["5447"],"URL":"https:\/\/doi.org\/10.1007\/s00261-026-05447-8","relation":{},"ISSN":["2366-0058"],"issn-type":[{"value":"2366-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"6 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}